Clinical characteristics of Korean type 2 diabetic patients in 2005

Kim, Dae Jung; Song, Kyoung Eun; Park, Ji Won; Cho, Hong Keun; Lee, Kwan‐Woo; Huh, Kap Bum

doi:10.1016/j.diabres.2007.01.067

Cited by 35 publications

(36 citation statements)

References 5 publications

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“…Therefore, it enables us to assess the mechanisms of diabetic nephropathy progression without the influence of such factors. In Asian countries, including Japan, most type 2 diabetic patients are non-obese and have impaired insulin secretion [19,20]. Therefore, it is important that these pathological types be divided to elucidate the detailed mechanisms of diabetic nephropathy.…”

Section: Discussionmentioning

confidence: 99%

Oxidative and Nitrosative Stress and Progression of Diabetic Nephropathy in Type 2 Diabetes

Fujii¹,

Kono²,

Nakai³

et al. 2010

Am J Nephrol

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Background: The role of nitric oxide (NO) is controversial in diabetes nephropathy progression and the mechanisms remain unknown, especially in non-obese type 2 diabetes. To examine mechanisms of nephropathy progression in non-obese type 2 diabetes, we used spontaneously diabetic Torii (SDT) rats, a newly established model of non-obese type 2 diabetes. Methods: Fourteen male Sprague-Dawley rats were used as a control (20 weeks, n = 6; 30 weeks, n = 8), and 20-week-old male SDT rats were divided into 2 groups: diabetic (DM, n = 8) and DM + insulin (n = 8) groups. Twenty- and 36-week-old rats were sacrificed, and blood, urine, and histomorphometric analyses, mRNA expression analysis of endothelial NO synthase (eNOS) and NADPH oxidase, and blood pressure measurement were performed. Results: At 36 weeks, NO metabolites, and 8-hydroxydeoxyguanosine (8-OHdG) were significantly higher in the diabetic group than in the other 2 groups. Further renal studies showed increased glomerular volume and mesangial area, and intensified eNOS, 8-OHdG, and nitrotyrosine immunostaining in the diabetic group. Oxidative and nitrosative stress were positively associated with increased glomerular volume and mesangial area, which were mostly recovered by insulin therapy. Conclusions: NO and oxidative stress increased in SDT rats, suggesting that these play key roles in nephropathy progression in non-obese type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Oxidative and Nitrosative Stress and Progression of Diabetic Nephropathy in Type 2 Diabetes

Fujii¹,

Kono²,

Nakai³

et al. 2010

Am J Nephrol

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“…In Korea, 70 to 80% of age-related, type 2 diabetic patients are non-obese, which is different from Western type 2 diabetic patients, the majority of whom are obese [3]. However, the precise role of ageing in the development of type 2 diabetes remains undefined.…”

Section: Introductionmentioning

confidence: 99%

A potential role for skeletal muscle caveolin-1 as an insulin sensitivity modulator in ageing-dependent non-obese type 2 diabetes: studies in a new mouse model

Khil

Cho

et al. 2008

Diabetologia

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Aims/hypothesis Type 2 diabetes mellitus is a common agedependent disease. We discovered that male offspring of non-diabetic C57BL/6 and DBA/2 mice, called JYD mice, develop type 2 diabetes when they grow old. JYD mice show characteristics of insulin resistance, hyperglycaemia and hyperinsulinaemia in old age without obesity. We postulated that the mechanism of age-dependent type 2 diabetes in this model relates to caveolin-1 status in skeletal muscle, which appears to regulate insulin sensitivity in the mice. Methods We compared insulin sensitivity in aged C57BL/6 and JYD mice using glucose and insulin tolerance tests and 18 Ffluorodeoxyglucose positron emission tomography. We also determined insulin signalling molecules and caveolin proteins using western blotting, and altered caveolin-1 levels in skeletal muscle of C57BL/6 and JYD mice using viral vector systems, to examine the effect of this on insulin sensitivity. Results In 30-week-old C57BL/6 and JYD mice, the basal levels of IRS-1, Akt and peroxisome proliferator-activated receptor-γ decreased, as did insulin-stimulated phosphorylation of Akt and insulin receptor β. However, caveolin-1 was only increased about twofold in 30-week-old JYD mice as compared with 3-week-old mice, whereas an eightfold increase was seen in C57BL/6 mice. Downregulation of caveolin-1 production in C57BL/6 mice caused severe impairment of glucose and insulin tolerance. Upregulation of caveolin-1 in aged diabetic JYD mice significantly improved insulin sensitivity with a concomitant increase of glucose uptake in the skeletal muscle. Conclusions/interpretation The level of skeletal muscle caveolin-1 is correlated with the progression of age-dependent type 2 diabetes in JYD mice.

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“…However, although FPG is a simple and convenient method, a considerable number of type 2 diabetic patients cannot be diagnosed based on FPG results alone, as discussed above. Several previous studies have shown that the FPG criterion is less sensitive for the detection of diabetes in elderly Korean people than the OGTT-based criterion [8][9][10]. Therefore, the OGTT remains a valuable test in the diagnosis of diabetes and the classification of IGT, especially in elderly Koreans.…”

Section: Oral Glucose Tolerance Test (Ogtt)mentioning

confidence: 99%

2011 Clinical Practice Guidelines for Type 2 Diabetes in Korea

Kim

et al. 2011

J Korean Diabetes

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Clinical characteristics of Korean type 2 diabetic patients in 2005

Cited by 35 publications

References 5 publications

Oxidative and Nitrosative Stress and Progression of Diabetic Nephropathy in Type 2 Diabetes

Oxidative and Nitrosative Stress and Progression of Diabetic Nephropathy in Type 2 Diabetes

A potential role for skeletal muscle caveolin-1 as an insulin sensitivity modulator in ageing-dependent non-obese type 2 diabetes: studies in a new mouse model

2011 Clinical Practice Guidelines for Type 2 Diabetes in Korea

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