Clinical characteristics of leg restlessness in Parkinson's disease compared with idiopathic Restless Legs Syndrome

Zhu, Xiaoying; Liu, Ye; Zhang, Xiao Jin; Yang, Wen Hao; Feng, Yanjun; Ondo, William G.; Tan, Eng King; Wu, Yun

doi:10.1016/j.jns.2015.07.008

Cited by 22 publications

(11 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies comparing the characteristics of PD-RLS(+) and iRLS patients have shown that the onset age is younger in iRLS than in PD-RLS(+), RLS is more severe in iRLS, and that the two groups exhibit opposite seasonal patterns 172425. In addition, a family history of RLS is more common and the ferritin level is higher in iRLS than in PD-RLS(+) 24.…”

Section: Discussionmentioning

confidence: 96%

“…The H&Y stage and UPDRS-III score did not differ significantly between our PD-RLS(+) and PD-RLS(−) groups. Previous studies found RLS to be associated with PD motor symptoms, suggesting that both motor symptoms and RLS are associated with the dopaminergic system;71017 that is, the decrease in dopamine production with PD progression could lead to RLS aggravation 18…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Restless Legs Syndrome in Parkinson's Disease Patients: Clinical Features Including Motor and Nonmotor Symptoms

You

Jeon

et al. 2019

J Clin Neurol

View full text Add to dashboard Cite

Background and Purpose We investigated the frequency and clinical features of restless legs syndrome (RLS) in patients with Parkinson's disease (PD). Methods This study included 74 PD patients. RLS was diagnosed in face-to-face assessments of all of the subjects based on diagnostic criteria of the International Restless Legs Syndrome Study Group revised in 2003. We analyzed the clinical features of PD patients with and without RLS and compared the data to idiopathic RLS. Results The frequency of RLS in the cohort was 21.6% ( n =16). Two (12.5%) of the patients with RLS were not treated with dopaminergic drugs, while 14 (24.1%) of the 58 patients without RLS received treatment with dopaminergic drugs. Anxiety, depression, and quality of life (QoL) were significantly worst in patients with RLS. PD patients with RLS had significantly worse sleep quality ( p =0.003) and worse scores on the cardiovascular subscale of the Scales for Outcomes in Parkinson's Disease for Autonomic Symptoms ( p =0.031) compared to those without RLS. In the group of PD patients with RLS, RLS preceding PD onset was related to a lower Hoehn and Yahr stage. Conclusions We found that the frequency of RLS in the present patients with PD was higher than that in our previous study of a general population of RLS subjects. Compared to the PD patients without RLS, the present PD patients with RLS suffered from worse sleep quality and QoL, depression, anxiety, and autonomic disturbances, especially those with cardiovascular problems.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Restless Legs Syndrome in Parkinson's Disease Patients: Clinical Features Including Motor and Nonmotor Symptoms

You

Jeon

et al. 2019

J Clin Neurol

View full text Add to dashboard Cite

show abstract

“…Some authors reported a higher prevalence of RLS/WED in female PD patients ( 25 , 26 , 34 ), but others did not find gender differences in PD patients with RLS/WED ( 21 , 40 , 43 ). There is a general agreement in literature considering PD patients with RLS/WED less likely to have a family history of RLS/WED ( 17 , 21 , 24 , 25 , 40 , 47 ). RLS/WED clinical manifestations in PD patients seem to be less severe ( 24 , 25 , 46 ) and RLS/WED symptoms in PD are often transient and irregular ( 17 , 24 , 40 ).…”

Section: Cross-sectional Studiesmentioning

confidence: 92%

Restless Legs Syndrome and Parkinson Disease: A Causal Relationship Between the Two Disorders?

2018

View full text Add to dashboard Cite

Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) is a common sleep related movement disorder that can be idiopathic or occurs in comorbidity with other medical conditions such as polyneuropathy, iron deficiency anemia, multiple sclerosis, hypertension and cardiovascular diseases. In recent years, a growing body of literature investigated the association between RLS/WED and Parkinson's Disease (PD). Several questions regarding the comorbidity between these two disorders are still unanswered. If the insurgence of RLS/WED may precede the onset of PD, or if RLS/WED could represent a secondary condition of PD and if impaired dopaminergic pathway may represent a bridge between these two conditions are still debatable issues. In this review, we critically discuss the relationship between RLS/WED and PD by reviewing cross sectional and longitudinal studies, as well as the role of dopamine in these disorders. A twofold interpretation have to be taken into account: dopaminergic therapy may have a crucial role in the development of RLS/WED in PD patients or RLS/WED can be conceived as an early manifestation of PD rather than a risk factor. Several studies showed a high prevalence of RLS/WED in PD patients and several findings related to dopaminergic and iron alterations in both disorders, however up to now it is difficult to find a point of agreement between studies. A greater number of systematic and strongly controlled longitudinal studies as well as basic pathophysiological investigations particularly in RLS/WED are needed to clarify this complex relationship.

show abstract

“…After the exclusion of mimics, the frequency of RLS further decreased to 12.5% in PD and 6.9% in controls . Another study assessed not only RLS but also leg motor restlessness in PD and found that PD patients with RLS had more severe parkinsonism when compared with PD patients without RLS . Similarly, using the Japanese version of the PD sleep scale, Suzuki and colleagues reported that the frequency of RLS was not significantly different between PD patients and controls (5.5% vs 2.2%), but nocturnal restlessness was significantly more frequent in PD patients.…”

Section: Current Developments In the Pathophysiology Of Rlsmentioning

confidence: 97%

Restless legs syndrome and periodic leg movements in patients with movement disorders: Specific considerations

Högl

Stefani

2017

Movement Disorders

View full text Add to dashboard Cite

Restless legs syndrome is a frequent neurological disorder with potentially serious and highly distressing treatment complications. The role and potential implications of periodic leg movements during sleep range from being a genetic risk marker for restless legs syndrome to being a cardiovascular risk factor. The diagnosis of restless legs syndrome in patients with daytime movement disorders is challenging and restless legs syndrome needs to be differentiated from other sleep-related movement disorders. This article provides an update on the diagnosis of restless legs syndrome as an independent disorder and the role of periodic leg movements and reviews the association of restless legs syndrome with Parkinson's disease and other movement disorders. © 2017 International Parkinson and Movement Disorder Society.

show abstract

Clinical characteristics of leg restlessness in Parkinson's disease compared with idiopathic Restless Legs Syndrome

Cited by 22 publications

References 29 publications

Restless Legs Syndrome in Parkinson's Disease Patients: Clinical Features Including Motor and Nonmotor Symptoms

Restless Legs Syndrome in Parkinson's Disease Patients: Clinical Features Including Motor and Nonmotor Symptoms

Restless Legs Syndrome and Parkinson Disease: A Causal Relationship Between the Two Disorders?

Restless legs syndrome and periodic leg movements in patients with movement disorders: Specific considerations

Contact Info

Product

Resources

About