Clinical Characteristics of Patients with Pustular Psoriasis: A Single-Center Retrospective Observational Study

Gisondi, Paolo; Bellinato, Francesco; Girolomoni, Giampiero

doi:10.3390/vaccines10081171

Cited by 7 publications

(11 citation statements)

References 25 publications

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“…17 -18 In total, 76.0% of patients in our study had a history of PsV, with a previously reported proportion of 10.7% to 85.5%. 12,[14][15][16][17][18][19][20] Studies have shown that female patients seem to be more common in GPP −PsV than GPP +PsV , 13,[17][18] which is consistent with our results. However, there was no statistically significant difference in the sex composition between the 2 groups.…”

Section: Discussionsupporting

confidence: 93%

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Characterization of Generalized Pustular Psoriasis in Northwest China: A Single-Center Retrospective Study

Li¹,

Peng²,

Geng³

2022

International Journal of Dermatology and Venereology

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Objective: This study was performed to investigate the clinical characteristics of patients with generalized pustular psoriasis (GPP) in Northwest China. Methods: The clinical data of patients with GPP were retrospectively collected in the Second Affiliated Hospital of Xi’an Jiaotong University from January 1, 2017, to December 31, 2021 and analyzed using the chi-square test and Mann-Whitney U test. Results: In total, 179 hospitalized patients were included. The male:female ratio was 1.16:1.00, and the mean age at onset was 35.05 ± 19.11 years. Psoriasis vulgaris was also present in 76.0% of patients, and a family history of psoriasis was present in 15.6%. The mean duration of hospitalization was 10.67 ± 4.31 days, and the mean duration of flares was 29.58 ± 24.32 days. Infections and suspected drugs were predisposing factors. A fever developed in 54.7% of patients, and pruritus developed in 70.9%. Some patients had involvement of the nails (38.0%), scalp (46.9%), and tongue (4.5%). Cardiovascular disease, hypertension, and gallbladder-related disease were common comorbidities. The efficacy of acitretin was 84.7%, that of methotrexate was 66.7%, and that of cyclosporine was 100%. Fifteen patients were treated with secukinumab or adalimumab and responded well. The mean response time was 6.34 ± 2.91 days based on the combination treatments. The mean duration of the treatment regimen was 111.35 ± 94.25 days, and approximately 46.6% (n = 131) of patients developed recurrence. Conclusion: Our retrospective study showed that most cases of GPP were accompanied by psoriasis vulgaris and associated with fever or pruritus. Acitretin had good therapeutic efficacy, but recurrence should be noted. Biologics are increasingly becoming effective treatments, but their superiority and safety need further research.

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Section: Discussionsupporting

confidence: 93%

“…Previous studies have suggested that female patients seem to be more common in GPP [11][12][13][14][15][16] ; however, the data vary according to geographical and racial differences (Table 4). Our study included more male than female patients (96/83), which is similar to the study performed by Ohata et al 18 (53/49).…”

Section: Discussionmentioning

confidence: 99%

Characterization of Generalized Pustular Psoriasis in Northwest China: A Single-Center Retrospective Study

Li¹,

Peng²,

Geng³

2022

International Journal of Dermatology and Venereology

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“…Comorbid diseases of patients with ACH were not different from those with GPP in which metabolic comorbidities were frequent 3,48 . Psoriatic arthritis occurs in 20.5%–36.4% of patients with ACH 3,48,49 . From our review (Table 1), the frequency of concomitant plaque psoriasis in patients with ACH (6.5%–46.2%) 3,45,48,49 appears lower than that of patients with GPP (31.3%–78%) 8,10,43,44 …”

Section: Introductionmentioning

confidence: 63%

“…3,48 Psoriatic arthritis occurs in 20.5%-36.4% of patients with ACH. 3,48,49 From our review (Table 1), the frequency of concomitant plaque psoriasis in patients with ACH (6.5%-46.2%) 3,45,48,49 appears lower than that of patients with GPP (31.3%-78%). 8,10,43,44…”

Section: Ach Alone and Predominate Achmentioning

confidence: 75%

“…The clinical data of a case series of ACH patients (n ≥ 5) and patients with predominately ACH are shown in Table 1. 3,[45][46][47][48][49] Although ACH can progress to GPP in a minority of patients, its clinical manifestations and course are different. It appeared that middleaged females were most commonly affected but the age of onset of ACH in Asian patients seemed to be lower than in Caucasian patients.…”

Section: Ach Alone and Predominate Achmentioning

confidence: 99%

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Acrodermatitis continua of Hallopeau and generalised pustular psoriasis: Should they be the same or different entities?

Chularojanamontri

Rattanakorn

Julanon

et al. 2023

Experimental Dermatology

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Acrodermatitis continua of Hallopeau (ACH) is a very rare, chronic and recurrent, inflammatory pustular eruption of the nail apparatus.It has also been called acrodermatitis continua suppurativa, pustular acrodermatitis, acrodermatitis perstans, dermatitis perstans and dermatitis repens. [1][2][3][4] Clinical characteristics are tender, sterile pustules on an inflamed, based on the tip of a digit, more frequently occurring on a finger than a toe. One or more digits can be affected which often leads to onychodystrophy and eventually anonychia.Rarely, osteitis resulting in osteolytic or bone resorption of the underlying phalanges can occur in long-standing and severe cases. 5,6

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Clinical and Disease Burden of Patients with Generalized Pustular Psoriasis: A Review of Real-World Evidence

Bhutani,

Farberg

2024

Dermatol Ther (Heidelb)

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Generalized pustular psoriasis (GPP) is a chronic, rare, and potentially life-threatening disease. There is limited understanding of patient characteristics in GPP and their correlation with disease progression or healthcare resource utilization. Our review aims to examine real-world evidence on these characteristics and the associated disease burden as related to economic and quality of life factors. Results showed that most patients with GPP experienced flares once a year, lasting from 2 weeks to 3 months, with > 80% of patients having residual disease post-flare, with/without treatment, indicating the long-term nature of GPP. The impact of GPP on patients’ daily activities was significant, even in the absence of a flare. GPP adversely affected mental health, and anxiety and depression were reported regularly. Patients with GPP had more comorbidities, were prescribed more medication, and had more inpatient and outpatient visits than in matched plaque psoriasis or general population cohorts. Improving the education of healthcare providers in diagnosing GPP, defining disease flares, and managing the disease, as well as making globally accepted clinical guidelines for GPP treatment available, could help to reduce the burden on patients with GPP. Effective therapies that control and prevent GPP flares and manage chronic disease are needed.

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Clinical Characteristics of Patients with Pustular Psoriasis: A Single-Center Retrospective Observational Study

Cited by 7 publications

References 25 publications

Characterization of Generalized Pustular Psoriasis in Northwest China: A Single-Center Retrospective Study

Characterization of Generalized Pustular Psoriasis in Northwest China: A Single-Center Retrospective Study

Acrodermatitis continua of Hallopeau and generalised pustular psoriasis: Should they be the same or different entities?

Clinical and Disease Burden of Patients with Generalized Pustular Psoriasis: A Review of Real-World Evidence

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