Clinical Characteristics of Respiratory Tract-Associated Streptococcus pyogenes at General Japanese Hospital in 2014

Abstract

Streptococcus pyogenesis most popularpathogen caused respiratory tract infection disease. This study was conducted to find out the recent clinical characteristics of Streptococcus pyogenes isolates from respiratory tract at Japanese hospital in 2014. Streptococcus pyogenes was identified by standard laboratory procedure. Antimicrobial susceptibility testing was performed by micro dilution assay according to CLSI recommendation. Respiratory tract isolates were defined as isolation from pharynx, nasal discharge, tonsillar, and sputum. Total one hundred sixty-one Streptococcus pyogenes were isolated among which 136 were from respiratory tract and 25 were from non-respiratory tract. Respiratory tract-associated Streptococcus pyogenes was isolated among which 102 were from male and 59 were from female. The age incidence among 0 -1 years age group was 8, among 1 -18 years age group, 131 (p < 0.01), among 19 -64 years age group, 17 (p < 0.01), and in 65-years it was 5. Although we investigated the relationship between season and bacterial isolation, we did not find any significant differences between respiratory tract and no respiratory tract isolation. However, our study revealed that clarithromycin was less antimicrobial effective in respiratory tract disease than in no respiratory tract disease significantly (p < 0.01). Although several antibiotics such as penicillin are still effective against Streptococcus pyogenes, incidence of Streptococcus pyogenes infection is not decreasing worldwide. Our study suggests the need for continuous epidemiological surveillance of Streptococcus pyogenes.

Comparison between the Effects of Oral and Intramuscular Administration of Shin’iseihaito (Xinyiqingfeitang) in a Streptococcus pyogenes‐Induced Murine Sinusitis Model

“…Our results also show that SSHT behaves in this manner by suppressing excessive immune responses while activating the necessary immune response. Our data also hint at SSHT being useful in the treatment of multidrug-resistant S. pyogenes [ 2 ]. Despite SSHT having an antibacterial effect, its effective optimum concentration is considerably high compared to those of commercially available western antibiotics.…”

“…Streptococcus pyogenes (S. pyogenes) are Gram-positive bacteria that cause numerous human diseases including sinusitis, pharyngitis, tonsillitis, otitis media, cellulitis, necrotizing fasciitis, and streptococcal toxic shock syndrome [ 1 ]. Although antibiotics such as penicillin have been effective in treating S. pyogenes for a long time, there have been reports of several serious issues associated with this therapy [ 2 ], one of them being the attenuation of the antibiotic effect [ 3 ]. Additionally, there has also been a recent rise in macrolide-resistant S. pyogenes in Japan and across the world [ 4 ].…”

Analysis of Streptococcus pyogenes reinfection in pediatric patients in Japan

“…Streptococcus pyogenes is a typical pathogenic bacterium that causes childhood infections resulting in acute pharyngitis and tonsillitis [1]. As it is prone to acquiring drug resistance, more than half of the S. pyogenes strains are macrolide resistant in Japan [2].…”

“…As it is prone to acquiring drug resistance, more than half of the S. pyogenes strains are macrolide resistant in Japan [2]. Thus, in Japan, macrolide antibiotics are not usually used against S. pyogenes, and the first choice is penicillin antibiotics [1]. Although no penicillin-resistant strains have been found in Japan, there have been cases of antibacterial treatment failure in which bacteria are detected again from patients despite the use of penicillin in clinical settings [1,3].…”

Effect of Lonicera caerulea var. emphyllocalyx Extracts on Murine Streptococcus pyogenes Infection by Modulating Immune System

“…Because it has several virulent factors such as streptolysin O, streptolysin S, NADase, SpeB protease, and streptococcus inhibitory of complement lysis, it causes various infectious diseases such as pharyngitis, tonsillitis, nephritis, cellulitis, and necrotizing fasciitis [1]. As the drug such as macrolide and tetracycline, resistant rate of S. pyogenes is gradually increasing worldwide including Japan [2]; novel anti- S. pyogenes drug besides popular antibiotics has been desired.…”