Clinical characteristics of sepsis-induced acute kidney injury in patients undergoing continuous renal replacement therapy

Cho, A. Young; Yoon, Hyun Ju; Lee, Kwang Young; Sun, In O

doi:10.1080/0886022x.2018.1489288

Cited by 34 publications

(36 citation statements)

References 50 publications

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“…The 28-day mortality of patients with CRRT was 62.5% in this research, matched for 62% in sepsis-induced acute kidney injury undergoing CRRT in previous reports [29].…”

Section: Discussionsupporting

confidence: 85%

CRRT in patients with HIV/AIDS

Guo

Liu

et al. 2020

Preprint

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Background: AKI is a common complication among human immunodeficiency virus (HIV)--infecting patients and resulting in increased morbidity and mortality. CRRT is a useful method and instrument in critically ill patients with fluid overload and metabolic disarray, especially in those who are unable to tolerate the intermittent hemodialysis. However, the epidemiology, influence factors of CRRT and mortality in patients with HIV/AIDS are still unclear in China. This study aims to study the HIV-infected patients admitted in ICU and explore the influence factors correlated with CRRT and prognosis.Methods: We performed a retrospective case-control study, in ICU of Beijing Ditan Hospital Capital Medical University, which is a top three hospital majoring in infectious diseases. From June 1,2005 to May 31,2017, 225 cases were enrolled in this research eventually.Results: 122(54.2%) patients were diagnosed with AKI during their stay in ICU, the number and percentage of AKI stage 1/2/3 were respectively 38(31.1%)/23(18.9%)/61(50%). 26.2% of AKI patients received CRRT during the stay of ICU. 56.25% CRRT patients died in ICU. The 28-day mortality was 62.5%, and the 90-day mortality was 75%. By multivariate logistics analysis, it showed that the use of vasoactive agents (OR=174.31,95% CI 1.743-65.271, p=0.018), diagnosis of PCP(OR=27.136,95% CI 1.855-397.066, p=0.016) and longer duration of CRRT (OR=1.034,95% CI 1.004-1.065, p=0.028) were independent risk factors for predicting patients’ death of CRRT in ICU. The Cox Analysis for the cumulative survival of AKI 3 patients between the CRRT and non-CRRT groups shows no significant differences (p =0.309).Conclusions: The incidence of AKI was 54.2% in HIV-infected patients admitted to the ICU, and about 26.2% AKI patients received CRRT during the stay of ICU.56.25%CRRT patients died in ICU. The 28-day mortality was 62.5%, and the 90-day mortality was 75%. The use of vasoactive agents, diagnosis of PCP were independent risk factors for predicting patients’ death of CRRT in ICU. The cumulative survival of AKI 3 patients between CRRT and non-CRRT groups shows no significant differences.

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“…The 28-day mortality of patients with CRRT was 62.5% in this research, matched for 62% in sepsis-induced acute kidney injury undergoing CRRT in previous reports [29].…”

Section: Discussionsupporting

confidence: 85%

CRRT in patients with HIV/AIDS

Guo

Liu

et al. 2020

Preprint

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“…Insufficient blood flow may be evident by low blood pressure, high blood lactate, or low urine output, which can eventually lead to kidney failure. In this case, we saw that the serum creatinine of the patient in both referrals reached above the normal and emergency dialysis was performed for him in the first time [9,10].…”

Section: Discussionmentioning

confidence: 86%

Repeated Sepsis in an 83-Year-Old Man With Cancer With Long-Lasting Invasive Treatments

Imanipour

Rasoulzadeh

Hosseini

2020

crcp

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Sepsis is a life-threatening condition that arises when the body's response to infection damages its own tissues and organs. Sepsis is caused by an inflammatory immune response triggered by an infection. Its risk factors include aging, weak immune system, major trauma, or burns. Treatment of sepsis is often based on fluid replacement and antibiotic therapy. In this study, an 83-year-old man is reported with two times of diagnosis of sepsis during three years. The first sepsis was due to an infection of the colostomy and the second one followed an infection at tracheostomy site. It seems that the disease and the underlying condition of the patient contribute to the occurrence of sepsis. The patient each time was discharged from the hospital after successful response to the treatment.

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“…There several studies that had shown that the following factors: age, platelet count, APACHE II score, serum creatinine level, a urine output of <0.05 mL/kg/h the first day, eGFR <45 mL/min, et al were associated with the prognosis of patients with AKI undergoing CRRT [18,19]. Moreover, there was study that reported that BMI was a risk for AKI, but was not associated with prognosis of the patients with sepsis treated with CRRT [20].…”

Section: Discussionmentioning

confidence: 99%

Higher body mass index is not a protective risk factor for 28-days mortality in critically ill patients with acute kidney injury undergoing continuous renal replacement therapy

et al. 2019

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Background: Acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) is a fatal and common clinical disorder in critically ill patients. Recent studies have shown that the relationship between BMI and the outcome of patients with AKI undergoing CRRT is conflicting. Methods: A retrospective cohort study based on data reuse. Univariate analysis, multi-factor regression analysis and subgroup analyses were used to explore the association of the BMI with the 28-days mortality risk in patients with AKI undergoing CRRT. Results: From January 2009 to September 2016, a total of 1120 cases met the inclusion criteria and were enrolled in this study. The univariate analysis showed that BMI was associated with 28-days mortality of patients with AKI undergoing CRRT, its HR value was 0.98 (0.96, 0.99). The multi-factor regression analysis showed that BMI was not associated with 28-days mortality of patients with AKI undergoing CRRT in the four models, the adjusted HR value of four models were 1.00 (0.96, 1.04), 1.01 (0.97, 1.04), 1.00 (0.96, 1.04) and 1.00 (0.96, 1.04), respectively. The subgroups analyses showed that the BMI was a risk factor of the 28-days mortality in patients with AKI undergoing CRRT when GFR !30 mL/min, its HR value was 1.04 (1.01, 1.09). Conclusion: Higher BMI was not a protective risk of 28-day mortality in patients with AKI undergoing CRRT. Especially, when GFR !30 mL/min, higher BMI increased the risk of the 28-day mortality rate in patients with AKI undergoing CRRT.

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Clinical characteristics of sepsis-induced acute kidney injury in patients undergoing continuous renal replacement therapy

Cited by 34 publications

References 50 publications

CRRT in patients with HIV/AIDS

CRRT in patients with HIV/AIDS

Repeated Sepsis in an 83-Year-Old Man With Cancer With Long-Lasting Invasive Treatments

Higher body mass index is not a protective risk factor for 28-days mortality in critically ill patients with acute kidney injury undergoing continuous renal replacement therapy

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