2022
DOI: 10.2174/1389450123666220421124542
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Clinical Combinatorial Treatments Based on Cancer Vaccines: Combination with Checkpoint Inhibitors and Beyond

Abstract: Cancer vaccine efficacy is influenced by several factors, but one of the most important is the immunosuppressive tumor microenvironment, which can attenuate treatment effects. The combination of therapeutic cancer vaccines with other immunotherapies or conventional therapeutic approaches can promote vaccine efficacy by increasing immune surveillance and tumor immunogenicity and modulating immune escape in the tumor microenvironment. Inhibitory checkpoints have a significant role in the modulation of anticancer… Show more

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Cited by 2 publications
(1 citation statement)
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“…Cancer remains a major issue for public health and new therapeutic approaches are needed to tackle this disease. In recent decades, more insights about tumor biology were discovered and some of them resulted in potential therapeutic targets [ 1 , 2 , 3 ]. These efforts enabled the definition of the chemical, physical and biological characteristics of the diseased tissue and highlighted the differences with the healthy counterpart.…”
Section: Introductionmentioning
confidence: 99%
“…Cancer remains a major issue for public health and new therapeutic approaches are needed to tackle this disease. In recent decades, more insights about tumor biology were discovered and some of them resulted in potential therapeutic targets [ 1 , 2 , 3 ]. These efforts enabled the definition of the chemical, physical and biological characteristics of the diseased tissue and highlighted the differences with the healthy counterpart.…”
Section: Introductionmentioning
confidence: 99%