Clinical Comparative Study: Efficacy and Tolerability of Tolperisone and Thiocolchicoside in Acute Low Back Pain and Spinal Muscle Spasticity

Abstract

Study DesignWe performed a multicentric, randomized, comparative clinical trial. Eligible patients were randomly assigned to receive 150 mg of Tolperisone thrice daily or 8 mg of Thiocolchicoside twice daily for 7 days.PurposeTo assess the efficacy and tolerability of Tolperisone in comparison with Thiocolchicoside in the treatment of acute low back pain with spasm of spinal muscles.Overview of LiteratureNo head on clinical trial of Tolperisone with Thiocolchicoside is available and so this study is done.MethodsThe assessment of muscle spasm was made by measuring the finger-to-floor distance (FFD), articular excursion in degrees on performing Lasegue's maneuver and modified Schober's test. Assessment of pain on movement and spontaneous pain (pain at rest) of the lumbar spine was made with the help of visual analogue scale score.ResultsThe improvement in articular excursion on Lasegue's maneuver was significantly greater on day 3 (p = 0.017) and day 7 (p = 0.0001) with Tolperisone as compared to Thiocolchicoside. The reduction in FFD score was greater on day 7 (p = 0.0001) with Tolperisone. However there was no significant difference in improvement in Schober's test score on day 3 (p = 0.664) and day 7 (p = 0.192). The improvement in pain score at rest and on movement was significantly greater with Tolperisone (p = 0.0001).ConclusionsTolperisone is an effective and well tolerated option for treatment of patients with skeletal muscle spasm associated with pain.

New insights on contraction efficiency in patients with Duchenne muscular dystrophy

“…22). Two patients were receiving muscle relaxants (thiocolchicoside), which are known to increase muscle flexibility (16,31). Six patients were receiving cardiovascular drugs (angiotensin-converting enzyme).…”

Back pain: diagnostic and differential aspects

“…Со времени публикации первого рандомизированного плацебо-контролируемого исследования 112 больных с рефлекторным болезненным мышечным спазмом, получавших монотерапию толперизоном, прошло более 20 лет [43]. Установленные в этом исследовании существенное уменьшение мышечного спазма и изменение порога болевой чувствительности, а также его безопасность были в последующем многократно подтверждены в ряде рандомизированных плацебо-контролируемых исследований [44,45].…”

“…Наличие у Мидокалма ® не только миорелаксирующих, но и противоболевых свойств показано в работе R. Rao и соавт. [44], включавшей 250 пациентов с острой и рецидивирующей болью в нижней части спины, которым назначали этот препарат в дозе 150 мг 3 раза в день: отмечены снижение болевого синдрома и увеличение функциональной активности. Исследование с участием 239 пациентов с острой неспецифической болью в спине, у которых оценивали эффективность совместного применения толперизона с НПВП в отношении боли и функционального статуса, чет- Л И Т Е Р А Т У Р А ко продемонстрировало статистически значимое превосходство комбинированной терапии над монотерапией НПВП и безопасность такой комбинации.…”

The effect of hip joint exercise using an elastic band on dynamic balance, agility and flexibility in healthy subjects: a randomized controlled trial

“…Pressing the measuring tape against subject's lower back, subjects were instructed to bend forward keeping the knees straight, and the distance between the most superior and inferior marks at the end of the range of movement (ROM) was recorded. The ROM was assessed by measuring the difference in length from the beginning point (from the 15 cm mark) to the end of the range of motion point [15].…”