Clinical Comparison of MEBO and Hyaluronic Acid Gel in the Management of Pain after Free Gingival Graft Harvesting: A Randomized Clinical Trial

Abstract

Aim. This study aimed to compare the effect of MEBO versus 0.2% hyaluronic acid gel (Gengigel®) applied to the palatal donor site on postoperative pain reduction and wound healing after free gingival graft harvesting. Methodology. Thirty-nine patients with different mucogingival defects were included in this study for harvesting a free gingival graft (FGG) for soft tissue augmentation. Patients were randomly assigned into three equal groups: group I (MEBO), group II (0.2% HA Gengigel®), and group III (control). Postoperative pain was recorded by using the Visual Analogue Scale (VAS). Analgesic consumption was recorded for 7 days postoperatively. Wound size was measured at baseline and on days 3, 7, 14, and 21. Postoperative healing of the palatal wound was assessed by the VAS score for color match on days 3, 7, 14, 21, and 42. Results. Results of this study showed significant postoperative pain reduction for the three groups; MEBO showed statistically significant less VAS score compared to the other two groups, while HA showed statistically significant less VAS score compared to the control group. Both MEBO and HA showed statistically significant less total analgesic consumption. No statistically significant difference was observed between groups for wound size. MEBO showed statistically significant higher VAS for color match. Conclusions. Both treatment modalities could reduce postoperative pain following harvesting of FGG and improve the palatal wound healing. However, MEBO showed better outcomes in terms of postoperative pain and color match.

Orodispersible hyaluronic acid film delivery for oral wound healing in rats

“…These findings are consistent with the results of a study that reported that HA improved oral wound healing. 24 , 25 However, there were no significant differences in the promotion of wound healing between the HA gel and HA film groups in this study.…”

Comparison of hyaluronic acid, hypochlorous acid, and flurbiprofen on postoperative morbidity in palatal donor area: a randomized controlled clinical trial

“…According to the results of the study, there was no difference between the two groups in terms of CM, and pain levels were higher in the control group compared to the HA group in the first seven days [ 44 ]. Hassan et al [ 45 ] compared 0.2% HA gel, MEBO, and the control group, and it was found that the study groups showed significantly lower VAS scores on the 2 nd and 3 rd days compared to the control group. They stated that from the 4th day, the patients did not have any pain although there was no difference between the groups in terms of wound size at any time.…”

Clinical Performance Evaluation of a Hyaluronic Acid Dental Gel for the Treatment of Traumatic Ulcers in Patients with Fixed Orthodontic Appliances: A Randomized Controlled Trial

“…The effects of HA gel on the oral cavity have also been documented in different clinical situations, such as the treatment of chronic periodontitis by the subgingival application after scaling and root planing, with a decrease in inflammation [ 28 , 29 , 30 , 31 , 32 ].…”