Clinical comparison of patients with osteonecrosis of the jaws, with and without a history of bisphosphonates administration

Bisphosphonates enhance bacterial adhesion and biofilm formation on bone hydroxyapatite

“…The importance of bacterial biofilm formation in the pathogenesis of BRONJ was reported previously, but the mechanisms responsible for bacterial colonization of denuded bone in patients on BPs were unclear (Sedghizadeh et al, 2008;Kos et al, 2010;Wei et al, 2012). Based on our experiments, one may suppose that BP-mediated bacterial adhesion plays an important role in this process.…”

“…At the same time, infection of the denuded bone with creation of biofilm M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT composed of Gram-positive and Gram-negative strains as well as anaerobes has been documented in pathological and microbiological reports concerning BRONJ (Sedghizadeh et al, 2008;Wei et al, 2012). Moreover, microbial colonization in BRONJ cases was also significantly higher than in bone necrosis occurring in the absence of BPs, raising the possibility that BPs could enhance bacterial colonization and biofilm formation in patients treated with these drugs (Kos et al, 2010). In a recent report, we demonstrated that one of the BPs, namely, pamidronate, increases the adhesion to hydroxyapatite (HA) and facilitates the colonization of clinical and reference strains of Pseudomonas aeruginosa and Staphylococcus aureus, species frequently associated with bone infections (Kos et al, 2013).…”

Comparison of local and systemic alendronate on distraction osteogenesis

“…The probability of adverse effects of bisphosphonates including osteonecrosis of the jaw, bleeding, inflammation, ulceration, nausea and abdominal pain in the upper gastrointestinal tract should be taken into consideration when using these drugs in humans 13,18 . Further studies are needed to determine benefits and side effects of alendronate when using maxillofacial operations in humans.…”

Treatment strategies and outcomes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with characterization of patients: a systematic review

“…17,27,44,49,68,69,72,73,76,78,89,90,94,[100][101][102][104][105][106][107]110,113,[116][117][118]123,[125][126][127][128][129][130][131][132][133][134][135][136]139,141,144,150,152,154 Major surgical intervention was reported in 22 publications, 17,44,68,92,100,103,106,115,…”