Clinical comparison of salicylic acid peel and LED-Laser phototherapy for the treatment of Acne vulgaris in teenagers

Abstract

Acne vulgaris treatments usually cause sensitivity, teratogenicity and bacterial resistance. Investigations of other therapeutic techniques, such as phototherapy, are highly relevant. Thus, we compared the effectiveness of two Acne vulgaris treatments in adolescents: peeling with salicylic acid (SA) and phototherapy. Teens were randomly divided into: group I, treatment with SA peels (10%) and group II, treatment with phototherapy (blue LED and red laser lights). Photographs were taken before and after ten sessions of each treatment, carried out weekly, and compared. To compare the differences between the treatments, the Student t-test was used. P values < 0.05 were considered significant. Both techniques are effective therapies for the treatment of acne in teenagers since the number of comedones, papules and pustules decreased significantly at the end of the session. However, when the two treatments were compared, phototherapy showed a significant difference in reducing the number of pustules. The combined use of red and blue lights due to their anti-inflammatory and wound-healing properties is a more efficient alternative for treating Acne vulgaris in relation to SA and proves more reliable and without side effects, improving the adolescents' skin health.

Differential responses of myoblasts and myotubes to photobiomodulation are associated with mitochondrial number

“…Hence, future studies may aim to evaluate the effects of combining both blue and NIR light to ensure light penetrates target tissue in vivo. The use of blue light may also be considered for superficial injuries including applications for wound healing, which have proven beneficial both in vitro and in vivo .…”

Blue-Light Therapy for Acne Vulgaris: A Systematic Review and Meta-Analysis

“…All 14 included trials were in English: 9 were full papers, [15][16][17][18][19][20][21][22][23] 2 were full papers with conference abstracts, 3,24 and 3 were conference abstracts alone [25][26][27] ( Table 1). The trials included 698 participants in total; most trials were small, with only 5 containing more than 50 participants.…”

“…20 Blue light alone was the intervention in 8 trials, [16][17][18][19][20]23 2 trials had both a blue-alone arm and a blue/redlight arm, 8,26 and 4 trials used a blue/red combination light. 3,15,21,27 Three trials combined the light intervention with topical treatments as adjuncts. 21,24,25 Five trials compared the blue light with no treatment or a sham device.…”

“…Alba et al, 15 Four trials reported the differences between bluelight and comparator groups in AEs. 8,17,21,26 One trial found no significant differences between groups, except dryness/itch (more frequent with benzoyl peroxide), 8 and another found AEs in all treatment groups, but none were more severe than "mild."…”

“…26 Two trials reported the number of AEs for the trial overall rather than by treatment group 3,16 ; few AEs were reported, and 4 trials reported narratively that the treatment had no side effects or was side-effect free. 15,18,24,25…”