Clinical comparisons between two subsets of gastric antral vascular ectasia

Ito, Muneyuki; Uchida, Yuzo; Kamano, S; Kawabata, Hidehiro; Nishioka, Mikio

doi:10.1067/mge.2001.113922

Cited by 79 publications

(63 citation statements)

References 10 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cirrhosis is commonly associated with a diffuse appearance of GAVE, involving the whole antrum without interruption; whereas non-cirrhotic patients are more likely to have a typical striped "watermelon" appearance. 11,12 Our two patients fit these respective endoscopic patterns. Epidemiological differences have been noted in these two groups, and characteristics of the two patterns are listed in table 1.…”

Section: Discussionmentioning

confidence: 99%

Gastric Antral Vascular Ectasia: Case Report and Review of the Literature

Kar

Mitra

Resnick

et al. 2012

Clinical Medicine & Research

View full text Add to dashboard Cite

Gast ric antral vascular ectasia (GAVE) is a rare cause of upper gastrointestinal (GI) bleeding, accounting for 4% of nonvariceal upper GI bleeding and associated with occult bleeding that manifests as iron deficiency anemia. 1 In recent years, it has emerged as a distinctive, well-defined entity within the spectrum of acquired vasculopathies of the stomach.We report two cases of GAVE presenting with two different endoscopy findings. We discuss the etiology, endoscopic features, histology, pathogenesis, and management options of this rare entity, and present a review of the pertinent literature. Case 1A man, age 57 years, presented with a one-week history of hematemesis. He described three episodes of coffee ground emesis, about a half-cupful on each occasion. The most recent episode occurred on the day of admission. His past medical history was significant for alcoholic cirrhosis with portal hypertension. He had an episode of hematochezia in the past that was diagnosed as a diverticular bleed on colonoscopy. His social history was significant for alcohol abuse, but he had quit drinking about 10 years prior.His vital signs showed a temperature of 98.9 o F, pulse 102 beats/minute, respiratory rate 16 breaths/minute, and blood pressure 120/79 mm Hg. Physical examination revealed a pale, jaundiced, malnourished male with ascites, pedal edema, and bilateral basal crackles. Initial laboratory studies were significant for hemoglobin of 8.8 gm/dL (reference range 12.9-17.3 g/dL). Serum liver tests Gastric antral vascular ectasia is the source of up to 4% of nonvariceal upper gastrointestinal bleeding. It can present with occult bleeding requiring transfusions or with acute gastrointestinal bleeding. It is associated with significant morbidity and mortality and has been associated with such underlying chronic diseases as scleroderma, diabetes mellitus, and hypertension. Approximately 30% of cases are associated with cirrhosis. We report two cases of gastric antral vascular ectasia with two strikingly different endoscopic appearances. We further describe the clinical, endoscopic, histologic, and therapeutic aspects of this entity.

show abstract

Section: Discussionmentioning

confidence: 99%

Gastric Antral Vascular Ectasia: Case Report and Review of the Literature

Kar

Mitra

Resnick

et al. 2012

Clinical Medicine & Research

View full text Add to dashboard Cite

show abstract

“…Recently, 2 papers reported that cirrhosis is commonly linked with a diffuse appearance of GAVE on endoscopy, whereas non-cirrhotic patients are more likely to have a typical stripy watermelon appearance [15, 16]. Whereas the majority of non-cirrhotic GAVE patients are females (71%), with a mean age of 73 years, cirrhotic GAVE patients tend to be younger (mean age 65 years) and male (75%) [11, 17].…”

Section: Epidemiologymentioning

confidence: 99%

Gastric Antral Vascular Ectasia (GAVE): An Update on Clinical Presentation, Pathophysiology and Treatment

2008

View full text Add to dashboard Cite

Gastric antral vascular ectasia (GAVE), though a rare disorder, causes up to 4% of non-variceal upper GI bleeding. This paper gives an overview of studies examining clinical presentation and pathophysiology, and reviews the current evidence for invasive and non-invasive treatments. GAVE is often associated with systemic illnesses, such as cirrhosis of the liver, autoimmune connective tissue disorders, bone marrow transplantation and chronic renal failure. The pathophysiological changes leading to GAVE have not been fully explained and remain controversial. Patient presentation varies from chronic iron-deficiency anaemia to heavy acute gastrointestinal bleeding. It is important to differentiate GAVE from portal hypertensive gastropathy as GAVE does not respond to measures reducing portal pressures. Endoscopic ablation (Nd:YAG-laser or argon plasma coagulation) is the first-line treatment of choice. As evidence for pharmacological therapy with oestrogen (and/or progesterone), tranexamic acid or thalidomide stems from case reports only, these should be used if endoscopic measures have failed to stop chronic blood loss. Surgical antrectomy should be reserved for unresponsive cases as it is associated with a high mortality. Ultimately, treatment of the underlying medical co-morbidities may lead to resolution of GAVE.

show abstract

“…Patients without cirrhosis but with GAVE are more likely to have classic WS performance described before, where majority of them are females (71%) with a relatively higher mean age of 73 years. This is similar to the epidemiologic features in human susceptible to cirrhosis and connective-tissue diseases to a certain extent [12,13]. The type with scattered lesions is difficult to distinguish from portal hypertensive gastropathy (PHG) under endoscopy.…”

Section: Patientmentioning

confidence: 75%

Case report of gastric antral vascular ectasia (GAVE)

Liu¹,

Ji²,

Jin³

et al. 2013

OJIM

View full text Add to dashboard Cite

Gastric antral vascular ectasia (GAVE) is a rare clinical disease which can cause recurrent upper gastrointestinal (GI) tract bleeding. It is responsible for about 4% of non-variceal upper GI haemorrhages. As one of the vascular diseases that happened in stomach, GAVE was also named as watermelon stomach (WS) for its characteristic endoscopic performance. Compared with portal hypertensive gastropathy (PHG) which with similar performances under endoscopy but often appeared as the result of portal hypertension, the etiology of GAVE is unknown. Recent years with further research it received several presumptions according to its histopathological features. Here we will introduce the disease systematically through two cases.

show abstract

Clinical comparisons between two subsets of gastric antral vascular ectasia

Cited by 79 publications

References 10 publications

Gastric Antral Vascular Ectasia: Case Report and Review of the Literature

Gastric Antral Vascular Ectasia: Case Report and Review of the Literature

Gastric Antral Vascular Ectasia (GAVE): An Update on Clinical Presentation, Pathophysiology and Treatment

Case report of gastric antral vascular ectasia (GAVE)

Contact Info

Product

Resources

About