Clinical considerations in patients with diabetes during times of COVID19: An update on lifestyle factors and antihyperglycemic drugs with focus on India

Gupta, Ritesh; Misra, Anoop

doi:10.1016/j.dsx.2020.09.009

Cited by 10 publications

(8 citation statements)

References 32 publications

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“…Management of post COVID-19 fatigue should be multidisciplinary including physician, psychological counsellor, nutritionist, and physical therapy expert(1). Blood glucose and blood pressure should be optimally controlled ( 21 , 22 ). Special care must be taken regarding nutrition; protein and vitamin supplements should be used as per requirement ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

High prevalence of post COVID-19 fatigue in patients with type 2 diabetes: A case-control study

Mittal

Ghosh

Bhatt

et al. 2021

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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Background Post COVID-19 syndrome (PCS) has emerged as a major roadblock in the recovery of patients infected with SARS-CoV-2. Amongst many symptoms like myalgia, headache, cough, breathless; fatigue is one of the major symptoms which makes the patient severely debilitated. Research on PCS, in particular fatigue, in patients with diabetes has not been done. Methodology In this prospective study, we included patients with type 2 diabetes (T2D) who had COVID-19 infection (mild to moderate severity), and matched T2D patients who did not suffer from COVID-19 infection. Demography, anthropometry, glycemic measures, treatment, COVID-19 infection details were recorded. Symptoms were scored using Chalder Fatigue Scale (reported as fatigue score, FS) and handgrip strength (in kg) was recorded by Jamar Hydraulic Hand Dynamometer. Results A total of 108 patients were included (cases, 52, controls, 56). Both groups were matched for age, duration of diabetes, BMI, TSH and vitamin D levels. T2D patients with COVID-19 infection had significant more fatigue when compared with patients without COVID-19 infection but comparable handgrip strength. Furthermore, patients with T2D with previous COVID-19 infection and who had FS >4 have had significant higher inflammation markers during acute illness, and post COVID-19, had increased post prandial blood glucose levels, lost more weight, had reduced physical activity and significantly lower handgrip strength as compared to those with FS <4. Conclusion Patients with T2D who had COVID-19 infection as compared to those without had significantly more fatigue after the acute illness, and those with higher fatigue score had reduced handgrip strength indicating sarcopenia. Rehabilitation of those with FS >4 after acute infection would require careful attention to nutrition, glycemic control and graduated physical activity protocol.

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Section: Discussionmentioning

confidence: 99%

High prevalence of post COVID-19 fatigue in patients with type 2 diabetes: A case-control study

Mittal

Ghosh

Bhatt

et al. 2021

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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“…Further, DM is comorbid with other diseases such as HTN, Cardiovascular disorders, and dyslipidemia. Hence, it is proposed that DM and its comorbidities are likely to contribute to a more severe form of COVID-19 infection [ 7 , 8 ]. Recent molecular studies have corroborated the clinical findings, showing that the SARS-Cov-2 virus can directly infect pancreatic cells [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Detrimental effect of diabetes and hypertension on the severity and mortality of COVID-19 infection: A multi-center case-control study from India

Jayaswal

Singh

Malik

et al. 2021

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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Aims This study aims to find a quantitative association between the presence of co-existing diabetes mellitus (DM) and/or hypertension (HTN) with COVID-19 infection severity and mortality. Methods A total of 813 patients with a positive COVID-19 were included. A case-control design was used to dissect the association between DM and HTN with COVID-19 severity and mortality. Results According to MOHFW guidelines, 535 (65.7%) patients had mild, 160 (19.7%) patients had moderate, and 118 (14.5%) patients had severe disease outcomes including mortality in 52 patients. Age, Neutrophil%, and Diabetes status were significantly associated with severe COVID-19 infection. After adjusting for age, patients with diabetes were 2.46 times more likely to have severe disease (Chi-squared = 18.89, p-value<0.0001) and 2.11 times more likely to have a fatal outcome (Chi-squared = 6.04, p-value = 0.014). However, we did not find evidence for Hypertension modifying the COVID-19 outcomes in Diabetic patients. Conclusion COVID-19 severity and mortality both were significantly associated with the status of DM and its risk may not be modified by the presence of HTN.

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“…A orientação atual enfatiza a importância de consultar equipes locais especializadas em diabetes e no controle da hiperglicemia (146). A insulina, tem sido sugerida, como o agente preferencial para o controle da hiperglicemia neste contexto (121). Nos Estados Unidos, um dos principais focos iniciais da gestão hospitalar foi mudar o atendimento de pacientes internados com diabetes para formatos "virtuais" sempre que possível, para reduzir a necessidade de equipamento de proteção individual.…”

Section: Gerenciamento No Hospitalunclassified

A epidemia do Diabetes mellitus encontra a pandemia da SARS-CoV-2 (COVID-19) / The Diabetes mellitus epidemic meets the SARS-CoV-2 (COVID-19) pandemic

Rego¹,

Picheth²,

Weiss³

et al. 2021

Braz. J. Hea. Rev.

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RESUMOA pandemia da doença coronavírus 2019 (COVID-19; SARS-Co-2) surgiu como um dos maiores desafios enfrentados pela humanidade. O diabetes mellitus, associado a hiperglicemia crônica, favorece comorbidades que podem ampliar o risco de severidade ou morte quando associado a viremia de COVID-19. A Idade avançada, múltiplas morbidades, hiperglicemia, doença cardíaca e resposta inflamatória severa são preditores de desfechos desfavoráveis na presença da viremia. Os diferentes aspectos da COVID-19 e suas

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Clinical considerations in patients with diabetes during times of COVID19: An update on lifestyle factors and antihyperglycemic drugs with focus on India

Cited by 10 publications

References 32 publications

High prevalence of post COVID-19 fatigue in patients with type 2 diabetes: A case-control study

High prevalence of post COVID-19 fatigue in patients with type 2 diabetes: A case-control study

Detrimental effect of diabetes and hypertension on the severity and mortality of COVID-19 infection: A multi-center case-control study from India

A epidemia do Diabetes mellitus encontra a pandemia da SARS-CoV-2 (COVID-19) / The Diabetes mellitus epidemic meets the SARS-CoV-2 (COVID-19) pandemic

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