Clinical course of Campylobacter infections in children

Grzybowska-Chłebowczyk, Urszula; Kalita, Barbara; Flak-Wancerz, Anna; Jasielska, Martyna; Więcek, Sabina; Wojcieszyn, Małgorzata; Horowska-Ziaja, Sabina; Chlebowczyk, Wojciech; Woś, Halina

doi:10.1016/j.pepo.2013.05.004

Cited by 10 publications

(7 citation statements)

References 12 publications

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“…[ 41 ] who reported that PCR revealed that all isolates were C. jejuni . Moreover, C. coli was the predominant isolate, as high as 1.11% and 3%, as reported in Egypt [ 25 ] and in Poland [ 48 ], respectively.…”

Section: Discussionsupporting

confidence: 55%

Prevalence, molecular detection, and virulence gene profiles of Campylobacter species in humans and foods of animal origin

et al. 2020

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Background and Aim: Campylobacteriosis is one of the most well-characterized bacterial foodborne infections worldwide that arise chiefly due to the consumption of foods of animal origin such as poultry, milk, and their products. The disease is caused by numerous species within the genus Campylobacter, but Campylobacter jejuni is the most commonly isolated species from established cases of human campylobacteriosis. This study was conducted to determine the prevalence and virulence of Campylobacter isolates from human, chicken, and milk and milk products in Egypt. Materials and Methods: A total of 1299 samples (547 chicken intestine and liver, 647 milk and milk products, and 105 human stool) were collected and microbiologically investigated, confirmed by multiplex polymerase chain reaction (PCR) targeting the 23S rRNA, hipO, and glyA genes specific for Campylobacter spp., C. jejuni, and Campylobacter Coli, respectively, followed by virulence genes (Campylobacter adhesion to fibronectin F [cadF] and cdtB) detection using PCR. Results: About 38.09%, 37.84%, and 8.5% of human stool, chicken, and milk and milk product samples, respectively, were bacteriologically positive, with a total of 302 Campylobacter isolates. All isolates were molecularly confirmed as Campylobacter spp. (100%) where 285 isolates (94.37%) were identified as C. jejuni and 17 isolates (5.62%) as C. coli. Regarding the virulence pattern, all isolates (100%) carried cadF gene while cytolethal distending toxin B gene was definite in 284/302 isolates (94%), concisely, 282/285 (98.94%) C. jejuni isolates, and in 2/17 (11.76%) C. coli isolates. Conclusion: The widespread presence of these highly virulent Campylobacter, especially C. jejuni, proofs the urgent need for the implementation of stringent control, public health, and food protection strategies to protect consumers from this zoonotic pathogen. The availability of information about pathogen virulence will enable enhanced local policy drafting by food safety and public health officials.

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Section: Discussionsupporting

confidence: 55%

Prevalence, molecular detection, and virulence gene profiles of Campylobacter species in humans and foods of animal origin

et al. 2020

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“…Previously, four cases of coinfection with C. jejuni and C. coli were observed in England in 2001, and 3.6% coinfection with different campylobacter strains has been reported in 1991. Also, 1.8% coinfection with C. jejuni and C. coli was observed in Brazil and India in 2010, and 22 children were reported to have coinfection with other enteropathogenic species of E. coli, rotavirus, and Salmonella in Poland in 2013 (2,(11)(12)(13).…”

Section: Discussionmentioning

confidence: 99%

“…Campylobacter is one of the major factors affecting about 400 million people worldwide each year (1). The infections of the genus campylobacter have been reported as the most common cause of acute diarrhea, especially among children under 3 and the elderly (2). C. jejuni and C. coli are the most common campylobacter species related to human gastroenteritis, and their frequency is 3 -4 times higher than that of the other bacterial enteropathogens like Salmonella and pathogenic Escherichia coli in patients with gastrointestinal infections (1).…”

Section: Introductionmentioning

confidence: 99%

A Report of Two Clinical Coinfections with Campylobacter jejuni and Campylobacter coli in Infantile Dysentery

Abbasi

Ghaznavi‐Rad

2019

Arch Pediatr Infect Dis

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Introduction: Campylobacter jejuni (C. jejuni) and Campylobacter coli (C. coli) are the most common campylobacter species related to human gastroenteritis. Due to their large similarity, these two species are not differentiated in laboratories. In this report, the coinfection with C. jejuni and C. coli was studied in two pediatric patients. The aim of the present report was to determine if simultaneous coinfection with C. jejuni and C. coli, with different antibiotic profiles, could happen. Case Presentation: In the present report, two patients clinically diagnosed with bacillary dysentery, showing fever and pus in their stool and undergoing treatment with cotrimoxazole, were microbiologically investigated through the modified Gram stain, culture and duplex PCR for diagnosing C. jejuni and C. coli. Based on microbiological and molecular results, coinfection with C. jejuni and C. coli were determined in both patients. Campylobacters isolated from patients were resistant to erythromycin, tetracycline, ciprofloxacin, ampicillin, gentamicin, and nalidixic acid. Also, in both patients, C. jejuni was sensitive to cotrimoxazole and ceftriaxone. In contrast, isolated C. coli were resistant to cotrimoxazole and sensitive to ceftriaxone. Conclusions: The two patients were simultaneously infected with C. jejuni and C. coli and both were carried all the antibiotic resistant genes under study. In spite of the sensitivity of C. jejuni to cotrimoxazole, no improvement was observed for C. coli due to its resistance to this antibiotic. This finding emphasizes on the important role of microbiology investigation once empirical therapy is needed. This issue must be taken seriously in pediatric hospitals.

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“…However, identification and understanding the transmission routes of Campylobacter infections is crucial for its prevention and control (Newell et al., 2017). The common and major route/pathways of campylobacteriosis includes through faecal-oral routes (Rosner et al., 2017), through consumption of contaminated undercooked meats or through consumption of contaminated food/water (Grzybowska-Chlebowczyk et al., 2013). Fig.…”

Section: Campylobacter Infectionsmentioning

confidence: 99%

Human campylobacteriosis: A public health concern of global importance

Igwaran

Okoh

2019

Heliyon

242

162

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Campylobacter species are among the leading cause of bacterial foodborne and waterborne infections. In addition, Campylobacter is one of the major causative agent of bacterial gastrointestinal infections and the rise in the incidence of Campylobacter infections have been reported worldwide. Also, the emergence of some Campylobacter species as one of the main causative agent of diarrhea and the propensity of these bacteria species to resist the actions of antimicrobial agents; position them as a serious threat to the public health. This paper reviews Campylobacter pathogenicity, infections, isolation and diagnosis, their reservoirs, transmission pathways, epidemiology of Campylobacter outbreaks, prevention and treatment option, antibiotics resistance and control of antibiotics use.

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Clinical course of Campylobacter infections in children

Cited by 10 publications

References 12 publications

Prevalence, molecular detection, and virulence gene profiles of Campylobacter species in humans and foods of animal origin

Prevalence, molecular detection, and virulence gene profiles of Campylobacter species in humans and foods of animal origin

A Report of Two Clinical Coinfections with Campylobacter jejuni and Campylobacter coli in Infantile Dysentery

Human campylobacteriosis: A public health concern of global importance

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