Clinical data and parenthood of 63 infertile and Y-microdeleted men

Patrat, Catherine; Bienvenu, Thierry; Janny, L.; Faure, Anne‐Karen; Fauque, Patricia; Aknin‐Seifer, Isabelle; Davy, Céline; Thiounn, Nicolas; Jouannet, Pierre; Lévy, Rachel

doi:10.1016/j.fertnstert.2008.10.033

Cited by 61 publications

(64 citation statements)

References 40 publications

(49 reference statements)

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“…Our study showed no significant differences in embryo implantation, biochemical pregnancy, clinical pregnancy, ectopic pregnancy, delivery, early miscarriage, late miscarriage and ratio of male/female babies in men with or without microdeletion, suggesting that Y chromosome AZFc microdeletion does not affect the outcomes of ICSI treatment. The studies of Patrat et al [33], Kihaile et al [10] and Choi et al [4] have shown similar results. Bellver [34] indicated that Y chromosome AZFc microdeletions do not seem to be related to recurrent spontaneous abortion (RSA) of unknown origin.…”

Section: Discussionmentioning

confidence: 54%

“…However, this differs with the report by Oates et al [27] who concluded that sperm production appeared stable over time. Table 6 shows that a have few studies precisely analyzed how Y chromosome microdeletion influences fertilization rate, embryo quality, and pregnancy rates [9,10,12,26,27,33]. Our study showed no significant differences in embryo implantation, biochemical pregnancy, clinical pregnancy, ectopic pregnancy, delivery, early miscarriage, late miscarriage and ratio of male/female babies in men with or without microdeletion, suggesting that Y chromosome AZFc microdeletion does not affect the outcomes of ICSI treatment.…”

Section: Discussionmentioning

confidence: 56%

“…Both sons and daughters are somatically healthy. In addition, at present., no increased risk of somatic effects in the offspring of men with Y chromosome microdeletion has been described [12,27,33]. Presently, PGD gives these couples the possibility to select female embryos for transfer.…”

Section: Discussionmentioning

confidence: 99%

“…What are the possible risks encountered by the patients: male infertility in the offspring, additional risk? Indeed, can we consider male infertility as a severe handicap, justifying sex selection [33]? Extensive counseling should be provided to all couples before and after genetic testing [23], especially for the couples that decide to pursue PGD.…”

Section: Discussionmentioning

confidence: 99%

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Y chromosome AZFc microdeletion may not affect the outcomes of ICSI for infertile males with fresh ejaculated sperm

Liu

Qiao

et al. 2013

J Assist Reprod Genet

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Purpose To explore whether the presence of a Y chromosome AZFc microdeletion confers any adverse effect on the outcomes of intracytoplasmic sperm injection (ICSI) with fresh ejaculated sperm. Methods A total of 143 oligozoospermia patients with Y chromosome AZFc microdeletion in ICSI cycles in a fiveyear period were studied. Infertile men with normal Y chromosome in ICSI at the same time-frame were used as controls matched to the study group for age of female, female's body mass index, male's age, infertility duration and number of oocytes retrieved. Retrospective case-control study was used. Results There were no significant differences between groups in clinical outcomes of endometrial thickness, transferred embryos, good embryo rates, implantation rates, biochemical pregnancy rates, clinical pregnancy rates, ectopic pregnancy rates, miscarriage rates, preterm birth rates, the ratio of male and female babies, newborn body height, newborn weight, low birth weight and birth defects (P>0.05). Patients with Y chromosome AZFc microdeletion had a lower fertilization rate (61.8 % vs. 67.8 %, P<0.05) and higher cleaved embryo rate (94.0 % vs. 88.1 %, P<0.05). Conclusions ICSI clinical outcomes for oligozoospermic patients with Y chromosome AZFc microdeletion are basically comparable to that of infertile patients with normal Y chromosomes. The results of ICSI were not affected by the AZFc deletion. Preimplantation genetic diagnosis (PGD) before ICSI for Y chromosome AZFc microdeletion may not be a justifiable regular procedure if the couples didn't care the vertical transmission of Y chromosome deletion.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Y chromosome AZFc microdeletion may not affect the outcomes of ICSI for infertile males with fresh ejaculated sperm

Liu

Qiao

et al. 2013

J Assist Reprod Genet

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“…Only spermatogonia and primary spermatocytes can be found in the testis, whereas spermatogenesis fails [27], which is consistent with the situation described in our case. The incidence of complete deletion of AZFb is equal to the incidence of AZFa deletion or slightly higher, accounting for 3~10 % of Yq microdeletions [28,29]. The AZFc is locateed within the distal deletion interval 6 of the Y chromosome and its length is about 3.5 Mb.…”

Section: Discussionmentioning

confidence: 99%

Non-chimerism and chimerism pseudo dicentric Y chromosome: two case reports about azoospermia and cytogenetic/molecular genetic analysis in the Chinese population

Ding

Sha

et al. 2013

J Assist Reprod Genet

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Objective To report the cytogenetic and molecular genetic analysis of the first two cases of non-chimerism and chimerism karyotype in Chinese male patients who suffer from azoospermia, which may be caused by pseudo dicentric Y chromosomes. Design Case study. Setting Academic reproductive medicine center. Patients Two male patients with azoospermia, carrying pseudo dicentric Y chromosome.Interventions Review the records of inquiry, testicular biopsy, pathological examination, semen routine examination, endocrine evaluation, cytogenetic chromosomal analysis, and FISH detection of peripheral blood to evaluate Y chromosome deletion. Main outcome measures To investigate the possible association among pseudo dicentric Y, chimeric status and azoospermia. Results Two patients were both diagnosed with azoospermia by a variety of andrology inspections. Further chromosomal analysis and FISH indicated their pseudo dicentric Y chromosome and different chimerism status. PCR confirmed simultaneous deletions of AZFb and AZFc regions in the Y chromosome of both patients. Conclusions Pseudodicentric Y chromosome affecting the long arm may lead to a male phenotype by duplicating the sex-determining region of Y chromosome (SRY) fragment and chimeric status may further impact patient's hormone levels, which obstruct spermatogenesis. However, the deletion of the azoospermia factor (AZF) is likely the key factor that causes azoospermia.

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Pre-IVF Evaluation of the Infertile Man

Harnisch

Oates

2012

In Vitro Fertilization

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Clinical data and parenthood of 63 infertile and Y-microdeleted men

Cited by 61 publications

References 40 publications

Y chromosome AZFc microdeletion may not affect the outcomes of ICSI for infertile males with fresh ejaculated sperm

Y chromosome AZFc microdeletion may not affect the outcomes of ICSI for infertile males with fresh ejaculated sperm

Non-chimerism and chimerism pseudo dicentric Y chromosome: two case reports about azoospermia and cytogenetic/molecular genetic analysis in the Chinese population

Pre-IVF Evaluation of the Infertile Man

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