Clinical data on rare Sulfamethoxazole crystalluria assessed by Fourier transform infrared spectrophotometry

Castiglione, Vincent; Cavalier, Étienne; Gadisseur, Romy

doi:10.1016/j.dib.2018.11.006

Cited by 4 publications

(5 citation statements)

References 5 publications

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“…Patients with pre-existing chronic kidney disease are also at high risk, as confirmed by our observations 27 , 30 , 42 .…”

Section: Discussionsupporting

confidence: 84%

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Sulfamethoxazole-induced crystal nephropathy: characterization and prognosis in a case series

Azencot,

Saint-Jacques,

Haymann

et al. 2024

Sci Rep

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Cotrimoxazole (Trimethoprim/Sulfamethoxazole-SMX) is frequently used in critically ill and immunocompromised patients. SMX is converted to N-acetyl-sulfamethoxazole (NASM) and excreted by the kidneys. NASM may form crystals in urine, especially in acid urine, that may induce a crystalline nephropathy. However, the imputability of crystals in acute kidney injury (AKI) has not been proven. We aimed to assess whether NASM crystals may promote AKI and to investigate risk factors associated with NASM crystalline nephropathy. Patients from Ile-de-France, France who developed AKI under SMX treatment introduced during hospitalization and had a crystalluria positive for NASM crystals were selected. Patients with excessive preanalytical delay for crystalluria or missing data regarding SMX treatment were excluded. We used the Naranjo score to assess the causal relationship between SMX and the development of AKI in patients with positive NASM crystalluria. Fourteen patients were included. SMX was the probable cause of AKI for 11 patients and a possible cause for 3 patients according to Naranjo score. Patients were exposed to high doses of SMX (but within recommended ranges), and most of them had a preexisting chronic kidney disease and were hypoalbuminemic. Urine pH was mildly acid (median 5.9). AKI occured more rapidly than expected after introduction of SMX (median 4 days) and recovered rapidly after drug discontinuation in most, but not all, cases. SMX is a probable cause of crystalline nephropathy. Monitoring of crystalluria in patients exposed to SMX may be of interest to prevent the development of crystalline nephropathy. Approval number of the study: BPD-2018-DIAG-008.

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“…Patients with pre-existing chronic kidney disease are also at high risk, as confirmed by our observations 27 , 30 , 42 .…”

Section: Discussionsupporting

confidence: 84%

“…Few other cases of NASM crystalluria have been reported in the literature 25 – 27 , 30 , 42 – 46 . The largest retrospective case series reported on NASM-positive crystalluria to date was published in 2018 by Castiglione et al 42 . It included seven patients with various bacterial infections.…”

Section: Discussionmentioning

confidence: 98%

Sulfamethoxazole-induced crystal nephropathy: characterization and prognosis in a case series

Azencot,

Saint-Jacques,

Haymann

et al. 2024

Sci Rep

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“…Supplementary data about infrared analysis protocol and detailed patients parameters are available in Data in Brief [1].…”

Section: Case Reportmentioning

confidence: 99%

Case report: Uncommon Sulfamethoxazole crystalluria

Castiglione

Cavalier

Gadisseur

2018

Clinical Biochemistry

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“…Meskipun KTZ memiliki efikasi yang baik, namun penggunaannya dalam jangka panjang tidak disarankan mengingat potensi peningkatan efek samping SMZ yaitu kristaliuria sehingga TMP dalam bentuk tunggal lebih direkomendasikan karena dianggap lebih aman. 1,2,3 TMP dalam bentuk tunggal sebagai antibiotik profilaksis terbukti efektif dalam mencegah kekambuhan pada infeksi saluran kemih pada pasien lansia 4 dan otitis media akut pada anak-anak. 5 Selain itu, TMP direkomendasikan untuk mengobati infeksi saluran kemih pada pria dewasa.…”

Section: Pendahuluanunclassified

Pengembangan dan Validasi Metode Bioanalisis Trimetoprim dalam Sampel Plasma dan Urin Manusia Simulasi Menggunakan KCKT-PDA

Notario

Amelia²,

Della³

2023

jki

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To monitor trimethoprim levels (TMP) in humans, a validated, simple, and cost-efficient analytical method is needed to be applied regularly. However, most of the methods used to establish TMP levels in urine and plasma use complex instrumentation. Therefore, in this study, a simpler High-Performance Liquid Chromatography-based (HPLC) method was developed. The separation was carried out using a GIST® C18 column (150 × 4.6 mm, 5 μm) at a temperature of 35°C which was fed by a mobile phase in the form of an acetic acid solution pH 2.5: acetonitrile (87:13, v / v) at a speed of 1.4 ml/min. Detection was performed with Photodiode Array Detector (PDA) at wavelengths of 254 nm and 243 nm to quantify TMP in urine and plasma samples respectively. The preparation of urine and plasma sequentially was carried out by the liquid-liquid extraction (ECC) method using ethyl acetate and the protein precipitation using acetonitrile. This method proved to be selective, linear (R=0.997), accurate with %error ≤ 10.29% at LLOQ level and above LLOQ value %error ≤ 10.45%, precision with %RSD ≤ 11.79% at LLOQ level and %RSD ≤ 10.82% above LLOQ. In addition, this method is quite sensitive for pharmacokinetic studies in the urine and monitoring of TMP levels in the blood with LLOQ 5 mg/L in both urine and plasma. The stability of trimethoprim in solution, urine, and plasma was conducted to ensure storage time. The developed method is proven to be valid and can be applied in pharmacokinetic studies and monitoring of trimethoprim drug levels in urine and plasma.

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Clinical data on rare Sulfamethoxazole crystalluria assessed by Fourier transform infrared spectrophotometry

Cited by 4 publications

References 5 publications

Sulfamethoxazole-induced crystal nephropathy: characterization and prognosis in a case series

Sulfamethoxazole-induced crystal nephropathy: characterization and prognosis in a case series

Case report: Uncommon Sulfamethoxazole crystalluria

Pengembangan dan Validasi Metode Bioanalisis Trimetoprim dalam Sampel Plasma dan Urin Manusia Simulasi Menggunakan KCKT-PDA

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