Clınical, demographic and histopathological prognostic factors for urothelial carcinoma of the bladder

Abstract

IntroductionOur aim is to evaluate the influence of clinical and histopathological parameters, including age, gender, tumor stage, grade, tumor differentiation, necrosis, lymphovascular/perineural invasion (LVI/PNI) and concomitant carcinoma in situ (CIS), on outcomes of patients with urothelial carcinoma of the bladder (UCB).Material and methodsA total of 84 patients who underwent radical cystectomy (RC) (n = 11) and radical cystoprostatectomy (n = 73) for muscle-invasive bladder cancer at our hospital between 2007-2013, were included in the study.ResultsThe mean age of patients at diagnosis was 66.1, of whom 75 were males and 9 were females. Of the 84 patients, 38 were ≤65 years and 46 were >65 years. Mean tumor diameter was 3.66 cm. There were 38 cases which showed divergent differentiations. Concomitant CIS was observed in 30 tumors, 41 cases showed tumor necrosis, 44 PNI and 61 LVI.The rate of overall survival (OS) in patients aged ≤65 years was statistically significantly higher than in those aged >65 years. A negative statistical relationship was found between OS with lymph node metastasis (LNM) and tumor differentiation. On the other hand, necrosis did not remain significant on multivariate analysis.No statistically significant relationship was found between smoking, tumor stage, PNI, LVI and concomitant CIS and OS.ConclusionsIn this study, advanced age, LNM, tumor differentiation were found to be independent prognostic risk factors associated with OS after RC. These additional factors, which may explain the different clinical course in patients with similar tumor stage and lymph node status, should be taken into consideration in treatment planning.

Impact of stage and comorbidities on five-year survival after radical cystectomy in Poland: single centre experience

“…Five-year OS in this study (31.7%) was slightly higher than previously reported by another Polish academic centre (5-year OS: 25% [ 19 ]), but substantially inferior to large series from recognized centres reported in recent years [ 3 – 9 ]. However, in smaller groups from less well-known institutions, survival rates are also close to ours [ 20 , 21 ]. Many factors may contribute to such an outcome, such as advanced stage at presentation, delay of treatment, improper operative technique, perioperative complication rate or health status of patients.…”

Prognostic Value of c-Myc Immunohistochemical Expression in Muscle Invasive Urothelial Carcinoma of the Urinary Bladder: A Retrospective Study

“…It is well known that the outcomes of patients with BC depend on different clinical and pathological factors, yet these factors do not always reflect the accurate prognosis. Therefore, studies are in a continuous search for accurate prognostic parameters (Knowles and Hurst, 2015;Kucuk et al, 2015). BC is one of the malignancies with a high molecular heterogeneity.…”

“…Prognosis of MIUC is related to various pathological and clinical parameters and the most powerful prognostic factor is the pathological stage. Although these prognostic factors represent significant predictors, they do not provide accurate predictions for individual patients (Kucuk et al, 2015;Mitra, 2016).…”

Characterization of PHGDH expression in bladder cancer: potential targeting therapy with gemcitabine/cisplatin and the contribution of promoter DNA hypomethylation

“…We set a cutoff level to 50 years old based on a previous study (Feng et al, 2015). Since there have been reports that age and gender are associated with the prognosis for BC patients (Burge and Kockelbergh, 2016;Feng et al, 2015;Kucuk et al, 2015;Shariat et al, 2010), we took the clinical factors into consideration when performing multivariate analysis even if the results were not significant in the univariate analysis of this study cohort.…”