Clinical Determinants of Health-Related Quality of Life in Patients With Irritable Bowel Syndrome

Spiegel, Brennan; Gralnek, Ian M.; Bolus, Roger; Chang, Lin; Dulai, Gareth S.; Mayer, Emeran A.; Naliboff, Bruce D.

doi:10.1001/archinte.164.16.1773

Cited by 168 publications

(145 citation statements)

References 31 publications

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“…The prevalence of IBS-C tends to be higher in women than in men (2:1 ratio) [1,10], and women tend to report more severe symptoms than men, especially abdominal symptoms [11][12][13]. Women and men may also be impacted differently in their daily life by symptoms [14], though gender may not be a significant predictor of health-related quality of life [15] or patient satisfaction [16].…”

Section: Discussionmentioning

confidence: 99%

Better Understanding and Recognition of the Disconnects, Experiences, and Needs of Patients with Irritable Bowel Syndrome with Constipation (BURDEN IBS-C) Study: Results of an Online Questionnaire

et al. 2018

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Introduction: The BURDEN IBS-C study was conducted to better understand the experiences, attitudes, and unmet needs of sufferers of irritable bowel syndrome with constipation (IBS-C) in comparison to the perceptions and challenges of healthcare providers (HCPs) who treat IBS-C patients. Methods: This was an author-developed, online questionnaire using KnowledgePanel Ò to survey individuals with IBS-C (N = 1311). HCPs participated in a complementary online questionnaire and were recruited separately (N = 331).

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Section: Discussionmentioning

confidence: 99%

Better Understanding and Recognition of the Disconnects, Experiences, and Needs of Patients with Irritable Bowel Syndrome with Constipation (BURDEN IBS-C) Study: Results of an Online Questionnaire

et al. 2018

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“…[16][17][18] The patients with IBS have impaired HRQOL that is significantly worse than that of patients with diabetes mellitus or end-stage renal disease. 19,20 A better outcome is achievable if a positive diagnosis of IBS is made, based on clinical symptoms alone, rather than making a diagnosis by exclusion. Several diagnostic criteria exist and each new criterion refers to the insufficiencies of the previous ones.…”

Section: Introductionmentioning

confidence: 99%

Assessment of IBS symptoms among patients of lower socio-economic strata attending medicine OPD in a tertiary care hospital in South Delhi

et al. 2017

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Background: Irritable bowel syndrome (IBS) is a common functional disorder throughout the world with no clear diagnostic markers. The diagnosis relies mostly on clinical presentation. In India, IBS is less estimated in lower socioeconomic group population. The objective of this study was to assess the proportions of symptoms compatible with IBS, and its prevalence among the patients of low socio-economic strata.Methods: An OPD based observational study carried out in a tertiary care hospital in south Delhi for a period of 10 years (Nov-2006 to Oct-2016). This hospital caters to low socioeconomic strata. All the study subjects were interviewed based on questionnaires compatible with Manning and Rome II criteriaResults: Symptoms of IBS was more in male (65.12%) and highest prevalence was in the age group 31 to 35 years (56.62%), flatulence was found to be the most common symptom compatible with IBS (58.37%) followed by pain abdomen (42.9%), loose motion (38.6%) and constipation (30.5%). The other important associated symptoms were headache 47.7% and insomnia in 44.62%.Conclusions: The symptoms compatible with IBS are common among the lower socioeconomic strata leading to a negative impact on their health-related quality of life and work performance, with high rate of physician's visits and further deteriorating their economic condition. Early diagnosis and health education may improve the quality of life and productivity in this population.

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“…7 Both central (ie, central nervous system) and peripheral mechanisms (ie, gastrointestinal tract) are thought to contribute to the origin of abdominal pain in IBS. 5 Peripheral mechanisms of abdominal pain may involve an increased sensitivity of the intestinal wall to local stimuli (ie, visceral hypersensitivity), 8 which results in increased activation of splanchnic afferent nerves 9 and erroneous activation of nociceptive brain regions.…”

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confidence: 99%

Mast Cell-Dependent Excitation of Visceral-Nociceptive Sensory Neurons in Irritable Bowel Syndrome

et al. 2007

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Background & Aims:Intestinal mast cell infiltration may participate to abdominal pain in irritable bowel syndrome (IBS) patients. However, the underlying mechanisms remain unknown. We assessed the effect of mast cell mediators released from the colonic mucosa of IBS patients on the activation of rat sensory neurons in vitro. Methods: Colonic mast cell infiltration and mediator release were assessed with quantitative immunoflorescence and immunoenzymatic assays. The effect of mucosal mediators was tested on mesenteric sensory nerve firing and Ca 2؉ mobilization in dorsal root ganglia in rats. Results: Mediators from IBS patients, but not controls, markedly enhanced the firing of mesenteric nerves (14.7 ؎ 3.2 imp/sec vs 2.8 ؎ 1.5 imp/sec; P < .05) and stimulated mobilization of Ca 2؉ in dorsal root ganglia neurons (29% ؎ 4% vs 11% ؎ 4%; P < .05). On average, 64% of dorsal root ganglia responsive to mediators were capsaicin-sensitive, known to mediate nociception. Histamine and tryptase were mainly localized to mucosal mast cells. IBS-dependent nerve firing and Ca 2؉ mobilization were correlated with the area of the colonic lamina propria occupied by mast cells (r ‫؍‬ 0.74; P < .01, and r ‫؍‬ 0.78; P < .01, respectively). IBS-dependent excitation of dorsal root ganglia was inhibited by histamine H 1 receptor blockade and serine protease inactivation (inhibition of 51.7%; P < .05 and 74.5%; P < .05; respectively). Conclusions: Mucosal mast cell mediators from IBS patients excite rat nociceptive visceral sensory nerves. These results provide new insights into the mechanism underlying visceral hypersensitivity in IBS.

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Clinical Determinants of Health-Related Quality of Life in Patients With Irritable Bowel Syndrome

Cited by 168 publications

References 31 publications

Better Understanding and Recognition of the Disconnects, Experiences, and Needs of Patients with Irritable Bowel Syndrome with Constipation (BURDEN IBS-C) Study: Results of an Online Questionnaire

Better Understanding and Recognition of the Disconnects, Experiences, and Needs of Patients with Irritable Bowel Syndrome with Constipation (BURDEN IBS-C) Study: Results of an Online Questionnaire

Assessment of IBS symptoms among patients of lower socio-economic strata attending medicine OPD in a tertiary care hospital in South Delhi

Mast Cell-Dependent Excitation of Visceral-Nociceptive Sensory Neurons in Irritable Bowel Syndrome

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