Clinical determination of serum nardilysin levels in predicting 30-day mortality among adults with malignant cerebral infarction

Chen, Fanghui; Wang, Yi; Jiang, Yi-Xiang; Zhang, Guihong; Zhi-min, Wang; Yang, Hui

doi:10.1016/j.cca.2019.03.1608

Cited by 2 publications

(1 citation statement)

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“…Nardilysin, N-arginine dibasic convertase, is often abbreviated as NRDC (NRD1, Nrdc), and is a metalloprotease of the M16 family which selectively cleaves at the dibasic terminus of arginine residues [ 10 ]. Recently, NRDC has been reported to be valuable in the early diagnosis of intrahepatic cholangiocarcinoma [ 11 ], malignant cerebral infarction [ 12 ], esophageal squamous carcinoma [ 13 ], and gastric cancer [ 14 ]. Moreover, it has been reported to be associated with tumor proliferation [ 15 ], epithelial–mesenchymal transition (EMT), and inflammatory signals, such as tumor necrosis factor-a (TNF-a), nuclear factor-kappa B(NF-κB), and heparin-binding epidermal growth factor-like growth factor (HB-EGF) [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Serum Nardilysin as a Prognostic Biomarker in Pancreatic Ductal Adenocarcinoma

Xu¹,

Xiong²,

Yang³

et al. 2022

JCM

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Background: Nardilysin, (N-arginine dibasic convertase, NRDC) has been reported to play an important role in cancer progression, and is associated with tumor proliferation signals and inflammatory signals, such as tumor necrosis factor-a (TNF-a) and heparin-binding epidermal growth factor-like growth factor (HB-EGF), through the activation of disintegrin and metalloproteinase (ADAM) proteases. NRDC has recently been revealed to be involved in the tumorigenesis of various types of cancer, including intrahepatic cholangiocarcinoma, malignant cerebral infarction, esophageal squamous cell carcinoma, and gastric cancer. However, the expression profiles and biological relevance of NRDC in pancreatic ductal adenocarcinoma have rarely been reported. Methods: We analyzed the NRDC expression profile in pancreatic ductal adenocarcinoma by enzyme-linked immunosorbent assay (ELISA) and identified NRDC as a circulating biomarker in the serum of 112 pancreatic ductal adenocarcinoma patients. The diagnostic value of NRDC was analyzed by the area under the curve (AUC) and the receiver operating characteristic (ROC) test. Results: Our results demonstrated that the clinical prognosis significance of NRDC with the clinical characteristics in pancreatic ductal adenocarcinoma (PDAC). NRDC was notably decreased in PDAC patient serum compared with the control group (p < 0.001). Furthermore, the present study found that the NRDC expression level was correlated with T grade (p < 0.001), metastasis(p < 0.001), differentiation(p < 0.001), and TNM stage (p = 0.011). Further bioinformatics analysis revealed that NRDC correlated with proliferation and migration pathways; in particular, it mediated cell-matrix adhesion-dependent activation in pancreatic ductal adenocarcinoma. Conclusions: Serum NRDC may play a useful diagnostic biomarker to evaluate the aggressive clinical features in PAAD patients.

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Section: Introductionmentioning

confidence: 99%

Serum Nardilysin as a Prognostic Biomarker in Pancreatic Ductal Adenocarcinoma

Xu¹,

Xiong²,

Yang³

et al. 2022

JCM

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A nomogram for predicting the in-hospital mortality after large hemispheric infarction

Sun

Liu

et al. 2019

BMC Neurol

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BackgroundLarge hemispheric infarction (LHI) is a severe form of stroke with high mortality and disability rates. The purpose of this study was to explore predictive indicators of the in-hospital mortality of LHI patients treated conservatively without decompressive hemicraniectomy.MethodWe performed a retrospective study of 187 consecutive patients with LHI between January 1, 2016 to May 31, 2019. The receiver operating curves were preformed to evaluate predictive performance of demographics factors, biomarkers and radiologic characteristics. Significant prognostic factors were combined to build a nomogram to predict the risk of in-hospital death of individual patients.ResultOne hundred fifty-eight patients with LHI were finally enrolled, 58 of which died. Through multivariate logistic regression analysis, we identified that independent prognostic factors for in-hospital death were age (adjusted odds ratio [aOR] = 1.066; 95% confidence interval [CI], 1.025–1.108; P = 0.001), midline shift (MLS, aOR = 1.330, 95% CI, 1.177–1.503; P < 0.001), and neutrophil-to-lymphocyte ratio (NLR, aOR = 3.319, 95% CI, 1.542–7.144; P = 0.002). NLR may serve as a better predictor than white blood count (WBC) and neutrophil counts. Lastly, we used all of the clinical characteristics to establish a nomogram for predicting the prognosis, area under the curve (AUC) of this nomogram was 0.858 (95% CI, 0.794–0.908).ConclusionThis study shows that age, MLS, and admission NLR value are independent predictors of in-hospital mortality in patients with LHI. Moreover, nomogram, serve as a precise and convenient tool for the prognosis of LHI patients.

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Clinical determination of serum nardilysin levels in predicting 30-day mortality among adults with malignant cerebral infarction

Cited by 2 publications

References 39 publications

Serum Nardilysin as a Prognostic Biomarker in Pancreatic Ductal Adenocarcinoma

Serum Nardilysin as a Prognostic Biomarker in Pancreatic Ductal Adenocarcinoma

A nomogram for predicting the in-hospital mortality after large hemispheric infarction

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