Clinical diagnosis of attention-deficit/hyperactivity disorder in survivors of pediatric brain tumors

Shabason, Emily K.; Brodsky, Cole; Baran, Julie; Isaac, Lee; Minturn, Jane E.; Ginsberg, Jill P.; Hobbie, Wendy L.; Fisher, Michael J.; Blum, Nathan J.; Hocking, Matthew C.

doi:10.1007/s11060-019-03165-4

Cited by 11 publications

(9 citation statements)

References 32 publications

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“…There was a significant level of heterogen ity across the different studies (I 2 = 54%, p < 0.01) and no significant publication bias w identified t (15) = 0.36, p = 0.72, Figure S5a. 2021) [83] reported more than o independent cohort in their study [24,30,36,37,39,40,42,43,[45][46][47]49,[55][56][57][58]60,61,[63][64][65][66][70][71][72][73][74][75]77,83]. (a) Abso-lute risk-attention problems; (b) Absolute risk-emotional; (c) Absolute risk psychosocial problems…”

Section: Absolute Risk-attention Problemsmentioning

confidence: 98%

Neurobehavioral Impairment in Pediatric Brain Tumor Survivors: A Meta-Analysis

Wang

Liu

Lee

et al. 2022

Cancers

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Purpose: The neurocognitive outcomes of pediatric brain tumor survivors have been extensively studied but the risk and predictors for neurobehavioral impairment are less clearly defined. We systematically analyzed the rates of emotional, psychosocial, and attention problems in pediatric brain tumor survivors. Methods: PubMed, Web of Science, Embase, Scopus, and Cochrane were searched for articles published between January 2012 to April 2022. Eligible studies reported neurobehavioral outcomes for PBTS aged 2 to <23 years with a brain tumor diagnosis before 18 years of age. A random-effect meta-analysis was performed in R. Results: The search yielded 1187 unique publications, of which 50 were included in the quantitative analysis. The estimated risk of having emotional, psychosocial, and attention problems were 15% (95%CI 10–20%), 12% (95%CI 9–16%), and 12% (95%CI 9–16%), respectively. PBTS were more likely to have emotional difficulties (Hedge’s g = 0.43 [95%CI 0.34–0.52]), psychosocial problems (Hedge’s g = 0.46 [95%CI 0.33–0.58]), and attention problems (Hedge’s g = 0.48 [95%CI 0.34–0.63]) compared to normal/healthy control subjects. There was no significant difference in the rates of neurobehavioral impairment between children with and without history of cranial radiotherapy. Conclusions: PBTS are at elevated risk of neurobehavioral impairment. Neurobehavioral monitoring should be considered as the standard of care for PBTS.

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Section: Absolute Risk-attention Problemsmentioning

confidence: 98%

Neurobehavioral Impairment in Pediatric Brain Tumor Survivors: A Meta-Analysis

Wang

Liu

Lee

et al. 2022

Cancers

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“…The literature on the effect of gender is somewhat ambiguous. Some studies report that gender is not related to cognitive outcome (Pulsifer et al, 2015;Shabason et al, 2019). Other studies report a difference.…”

Section: Secondary Medical Complicationsmentioning

confidence: 99%

Neuropsychological functioning in survivors of childhood medulloblastoma/CNS-PNET: The role of secondary medical complications

Stadskleiv

Stensvold

Stokka

et al. 2020

The Clinical Neuropsychologist

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Objective: To investigate the long-term cognitive consequences of malignant pediatric brain tumor and its treatment, and factors explaining variability in cognitive functioning among survivors. Method: A geographical cohort of survivors of pediatric medulloblastoma (MB) and supratentorial primitive neuroectodermal tumor (CNS-PNET), treated between 1974 and 2013, was invited to participate. Of the 63 surviving patients, 50 (79%) consented to participation. The participants were tested with a battery of neuropsychological tests covering a wide age range. Verbal cognition, nonverbal cognition, processing speed, attention, memory, executive functioning, and manual dexterity were assessed. The participants were between 5:5 and 51:11 years of age at time of assessment. Assessments took place on average 19 years after primary tumor resective surgery. Results: One participant had a severe intellectual disability. For the rest, IQ varied from 52 to 125, with a mean score of 88.0 (SD 19.7). Twenty-eight (56%) of the participants had full-scale IQ scores in the age-average range or above. Gender, age at operation, time since operation, the presence of secondary medical complications, and treatment variables explained 46% of the variability in IQ scores, F(4,44) ¼ 9.5, p<.001. The presence of endocrine insufficiency in combination with either epilepsy and/or hydrocephalus was associated with lowered IQ, lowered processing speed, and memory impairments. Conclusion: Patients treated for childhood MB and CNS-PNET have a lifelong risk of medical sequelae, including impaired cognitive functioning. This study adds to the literature by demonstrating the importance of following neuropsychological functioning closely, especially processing speed, learning, and memory, in survivors who have multiple secondary medical complications.

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Section: Introductionmentioning

confidence: 99%

“…13,14 Although the exact etiology of ADHD is often unclear, there is a strong hereditable component, 15 and associations have been found with low birth weight, prematurity, 16 male sex, 17 traumatic brain injuries, and brain tumors. 18,19 It has been reported that 19% to 35% of children with cerebral palsy also have ADHD, 20 which is approximately 6 times higher than in the general population. Children with epilepsy also have a 2.5 to 5.5 times higher risk of ADHD.…”

Section: Introductionmentioning

confidence: 99%

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Association of Perinatal and Childhood Ischemic Stroke With Attention-Deficit/Hyperactivity Disorder

et al. 2022

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Key Points Question Does the risk of attention-deficit/hyperactivity disorder (ADHD) increase after pediatric stroke, and is that risk associated with family history of ADHD, adverse motor outcomes, or comorbid epilepsy? Findings This nationwide cohort study of 1320 patients who had perinatal or childhood stroke and 13 141 matched controls found a 2-fold increased risk of ADHD after stroke. Development of adverse motor outcomes and/or epilepsy were associated with a further elevated risk in children with perinatal stroke. Meaning These findings suggest that children may face an increased risk of ADHD after stroke and that surveillance for ADHD should be considered by pediatricians performing follow-up of children with pediatric stroke.

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Clinical diagnosis of attention-deficit/hyperactivity disorder in survivors of pediatric brain tumors

Cited by 11 publications

References 32 publications

Neurobehavioral Impairment in Pediatric Brain Tumor Survivors: A Meta-Analysis

Neurobehavioral Impairment in Pediatric Brain Tumor Survivors: A Meta-Analysis

Neuropsychological functioning in survivors of childhood medulloblastoma/CNS-PNET: The role of secondary medical complications

Association of Perinatal and Childhood Ischemic Stroke With Attention-Deficit/Hyperactivity Disorder

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