Clinical diagnosis of sepsis

Jana, Atanu Kumar; Sridhar, Soorya

doi:10.1177/0973217920090107

Cited by 2 publications

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“…Neonatal sepsis is a common cause of neonatal morbidity and mortality with an annual incidence of 2-6/1000 live births in the developed countries of the world. 1 In the developing countries, the estimated incidence is 3-4 times higher and neonatal sepsis remains one of the most common reasons for admission in neonatal unit. 2 This is mainly due to lack of health education, poor antenatal care and lack of trained staff to conduct deliveries.…”

Section: Introductionmentioning

confidence: 99%

Comparision of Clinical and Laboratory Parameters in Culture Proven and Unproven Early Onset Sepsis in NICU

Shrestha

Singh

Shrestha

et al. 2015

Kathmandu Univ. Med. J.

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Backgroud Early onset sepsis remains a major cause for neonatal morbidity and mortality.Objectives The aim of this study was to describe and compare the clinical and laboratory characteristics of neonates in neonatal intensive care unit with culture positive and negative early onset sepsis and verify if there were any differences between the groups.Methods A one year comparative prospective study was conducted from January 2011 to January 2012 in neonatal intensive care unit (NICU), Dhulikhel Hospital, Kathmandu University Hospital (KUH).Results Out of 215 cases of suspected neonatal sepsis, 192 (89.30%) cases of early onset sepsis were admitted in neonatal intensive care unit. Out of which 82 cases (42.7%) had blood culture positive and 110( 57.3%) had culture negative but compatible with features of clinical sepsis. There were no cases of culture proven meningitis and urinary tract infections.The clinical characteristic did not show any statistical differences between the study groups except for seizure which was found to be high in culture positive cases (p= 0.041). The hospital stay in neonatal intensive care unit was significantly longer (p=0.02) in culture positive cases. As for the laboratory test there were no differences found between the two study groups except cases of meningitis was more in culture proven early onset sepsis (p=0.00). The overall mortality in early onset sepsis was 36.95%. The higher mortality of 64.7% was seen in culture positive cases but statistically not significant.Conclusion Clinical manifestation and laboratory test were insufficient to distinguish between neonatal infection with blood culture positive and negative sepsis, hence both culture positive and negative cases should be treated promptly and equally.Kathmandu Univ Med J 2013; 11(4): 310-314

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Section: Introductionmentioning

confidence: 99%

Comparision of Clinical and Laboratory Parameters in Culture Proven and Unproven Early Onset Sepsis in NICU

Shrestha

Singh

Shrestha

et al. 2015

Kathmandu Univ. Med. J.

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“…About 99% of these neonatal deaths take place in developing nations. 2 Neonatal sepsis is a common reason for neonatal morbidity and mortality with an annual incidence of 2-6 per 1000 live births in the developed countries of the world 3 whereas in developing countries, mortality rate due to neonatal sepsis is between 11-68/1000 live birth. 4 Neonatal sepsis is defined as a clinical syndrome in an infant 28 days of life or younger, manifested by systemic signs of infection and isolation of a bacterial pathogen from the bloodstream.…”

Section: Introductionmentioning

confidence: 99%

A Study of Clinico-pathological Profile of Suspected and Confirmed Neonatal Sepsis at Kathmandu Medical College

Shrestha

2020

Nep. Med. Coll. J.

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Neonatal sepsis is a common reason for neonatal morbidity and mortality. Only clinical manifestations are inadequate to diagnose neonatal sepsis. In context of Nepal, there has been few studies correlating bacterial and clinical profile but none till now has managed to define the most adequate parameters to diagnose neonatal sepsis with certainty. Hence, this study is conducted to describe and compare clinical and laboratory characteristics of culture positive and clinically suspected sepsis (blood culture negative) and then assess whether differences exist between them. A descriptive prospective study was carried out for a period of one year starting from April 2017 to March 2018 at the NICU of Kathmandu Medical College. A total of 129 culture proven and suspected septic neonates were included. Clinical features, septic screening including blood culture, biochemical tests and radiological findings were taken into consideration. The incidence of definite neonatal sepsis was 22.4%. The most common bacterial isolates were gram negative bacteria. Klebsiella spp (48%) followed by CoNS (17%), Acinetobacter spp (14%), Enterobacter spp (7%), Pseudomonas (7%) and Staphylococcus aureus (7%) were isolated. Different non specific clinical features like respiratory and gastro-intestinal symptoms were seen. The neonates with clinical features had positive correlation with abnormal laboratory parameters with statistically significant p value, suggesting that septic neonates showed abnormal laboratory parameters. This data emphasizes the role of laboratory parameters other than blood culture for the diagnosis and empirical treatment of neonatal sepsis.

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Clinical diagnosis of sepsis

Cited by 2 publications

References 0 publications

Comparision of Clinical and Laboratory Parameters in Culture Proven and Unproven Early Onset Sepsis in NICU

Comparision of Clinical and Laboratory Parameters in Culture Proven and Unproven Early Onset Sepsis in NICU

A Study of Clinico-pathological Profile of Suspected and Confirmed Neonatal Sepsis at Kathmandu Medical College

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