Clinical-diagnostic significance of detection of soluble adhesion molecules sICAM and sVCAM in children with typical haemolytic-uraemic syndrome

Pankratenko, Tatiana; Moskalets, O.V.; Abaseeva, Tatiana

doi:10.20953/1817-7646-2017-4-7-14

Cited by 4 publications

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“…Endothelial dysfunction induced by effects of Shiga toxin plays the key role in the pathogenesis of tHUS [3,5]. Hense, cell adhesion molecules as biomarkers of endothelial activation/disfunction may be predictors of complications and poor outcomes [2].…”

Section: Introductionmentioning

confidence: 99%

“…Отмечаетcя роcт чаcтоты этой патологии, cклонноcть к рецидивирующему течению, развитие опаcных для жизни оcложнений [5,10]. Важными предcтавляютcя факты, cвидетельcтвующие, что у 40-60 % взроcлых больных иcтоки заболевания находятcя в детcком возраcте [1,2,8].…”

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Soluble adhesion molecules in children with typical hemolytic uremic syndrome

Moskalec¹,

Pankratenko²,

Abaseeva³

2018

Scientific Achievements of the Third Millennium

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Scientific achievements of the third millennium -27-The effect was assessed by clinical signs and drainage functions.Drainage was used in 42 patients. Due to the meager amount of discharge in 38 patients, the drains were removed the day after the operation. In 4 people, the drainage tube was removed on days 3 and 5 after the intervention. At ultrasound examination on the 3rd and 5th day after the operation, fluid accumulation in the wound was not detected. Long-term results were traced in 33 patients. There were no recurrences. Patients are physically active, working capacity is preserved.Conclusions. 1. Intraperitoneal plastic has proved its effectiveness, allowed to carry out operations without removal of hernial bag, exclusion of injuring mobilization, wide dissection of subcutaneous tissue and reduction in the size of surgical approaches.

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Section: Introductionmentioning

confidence: 99%

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Soluble adhesion molecules in children with typical hemolytic uremic syndrome

Moskalec¹,

Pankratenko²,

Abaseeva³

2018

Scientific Achievements of the Third Millennium

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“…D+HUS isanacute disease characterizedbyprodromaldiarrheafollowed by acute renalfailure,thrombocytopeniaand non-immunehemolyticanemia.The most common cause of D+HUS is enterohemorragic Escherichia coli producing Shiga toxin [1,4]. Endothelial dysfunction inducedby effectsof Shigatoxinhasbeenrecognizedasthetrigger eventinthedevelopmentof D+HUS [5].Hense,adhesionmoleculesasbiomarkersof endothelial activation/disfunctionmaybeuseful forassessment ofriskofcomplicationsand poor outcomes [2,3].…”

Section: Introductionmentioning

confidence: 99%

Cell adhesion molecules in childrenwith diarrhea-associated hemolytic uremic syndrome

Pankratenko¹,

Moskalec²

2018

General Question of World Science

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ThelevelsofsolubleadhesionmoleculessICAM-1andsVCAM-1werestudied in bloodof childrenwith diarrhea-associatedhemolyticuremicsyndrome (D+HUS)andin bloodof childrenwhohadpreviouslyhadD+HUS(controlgroup). Wecompared these markerswith somelaboratory characteristics of thromboticmicroangiopathy activity, inflammationandseverityofacutekidney injury.Werevealedthatserumconcentrationsof sICAM-1 were lower and sVCAM-1 were higher in children with acute D+HUS than in controls. But the prognostic value ofthese markers still remains unclear.

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“…Endothelial activation followed by disfunction plays a very important role in the pathogenesis of tHUS [3]. Hense, adhesion molecules as biomarkers of endothelial activation may be useful for assessment of risk of complications and poor outcomes [2,5].…”

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confidence: 99%