Clinical diagnostics of undifferentiated connective tissue dysplasia

Aim: to study a role of undifferentiated connective tissue dysplasia (uCTD) in etiology of cervical incompetence and its effect on pregnancy and childbirth course.Material and Methods. There were enrolled 60 patients with cervical incompetence. Patients were divided into 3 groups according to the modified CTD scale: group 1 - patients without uCTD (n = 21); group 2 - patients with mild uCTD (n = 25); group 3 - patients with moderate-to-severe uCTD (n = 14). Intensity of CTD clinical signs was assessed based on health status, gynecological and obstetric history, the course of pregnancy, labor and the postpartum period.Results. It was found that patients with more prominent CTD developed earlier (r-Spearman = -0.26) and more marked (r-Spearman = -0.29) cervical shortening and opening of the internal orifice of the uterus (r-Spearman = 0.28). It was also noted that likelihood of occurring preterm labor was significantly higher in patients with CTD (p = 0.02).Conclusion. The data obtained evidence that uCTD affects intensity of manifested cervical insufficiency and rate of preterm delivery.

show abstract

Connective tissue dysplasia in the genesis of cervical incompetence

Фотина

Zakirova

Алексеенкова

et al. 2021

Akušerstvo, ginekologiâ i reprodukciâ

View full text Add to dashboard Cite

show abstract

Protocols on correction of signs of undifferentiated connective tissue dysplasia using hardware and injection techniques in cosmetic patients

Svechnikova¹,

Morzhanaeva

Gorskaya³

et al. 2023

Medicinskij sovet

View full text Add to dashboard Cite

Undifferentiated connective tissue dysplasia (UCTD) is a genetically determined condition with a progressive course characterized by defects in the fibrous structures and the basic connective tissue substance, leading to impaired formation of organs and systems, which determines the features of the associated pathology, as well as the pharmacokinetics and pharmacodynamics of drugs. In dermatological and cosmetological practice, the issue of UCTD is very topical, as individual external presentations of the connective tissue dysmorphogenesis among young people can reach 85.4%. In recent decades, a real revolution has taken place in aesthetic medicine, which is associated with the emergence of new injectable products, development of hardware, cellular and thread techniques. Every year mew methods of treatment emerge and the existing ones are improved. Statistics of the past years show that minimally invasive non-surgical interventions are becoming more and more popular in all countries, their number significantly exceeds the number of surgical operations. To date, there are 2 groups of methods aimed at collagen stimulation: hardware techniques and injection methods. The effectiveness of the use of polylactic acid drugs as the first-line drugs for the correction of UCTD in order to prevent premature ageing was evaluated in the presented clinical cases. Patients with a cosmetology profile were treated according to the complex protocols that included amino acid replacement therapy, IV therapy, contour correction with drugs containing polylactic acid and hardware techniques (microneedle RF lifting with insulated and non-insulated needles, ultrasonic SMAS lifting, ablative laser techniques, Ipl-therapy). As a result, an algorithm for managing a patient with UCTD was developed in the cosmetology practice. The provided clinical cases show that the detection of signs of UCTD can significantly improve the patient’s quality of life and prevent premature aging.

show abstract

Correlations of cytokines, regulating the synthesis of structural macromolecules of connective tissue, in undifferentiated connective tissue dysplasia in adolescent girls

Reznichenko,

Zoloto,

Maylyan

et al. 2023

Med. vestn. Ûga Ross.

View full text Add to dashboard Cite

Objective: to study the correlations of serum levels of cytokines, regulating the synthesis of structural macromolecules of connective tissue, in undifferentiated connective tissue dysplasia in adolescent girls with menstrual cycle disorders. Materials and methods: 176 adolescent girls aged 11 to 17 years with menstrual cycle disorders (MCD) and undifferentiated connective tissue dysplasia (UCTD) and 69 healthy girls of the same age were examined. Levels of cytokines IL-1β, IL-4, IL-6, IL-10, IL-17A, TNF-α, OPG, RANKL were studied in serum samples. Results: a significant increase in serum IL-6 and RANKL (p<0,01), as well as a tendency (p<0,1) to increase OPG production was found in adolescent girls with UCTD with MCD. In UCTD with NMC, correlations between the studied cytokines are much more common than in the control group (p=0,01). The most pronounced in adolescent girls with UCTD are positive correlations (moderate strength) between the concentrations of three cytokines IL-6, RANKL and OPG. Conclusions: The data obtained reflect the mechanisms of cytokine dysregulation of metabolism and remodeling of connective tissue and indicate the development of a weakly expressed systemic inflammatory process in UCTD with MCD in adolescent girls. The results of the study can be used to develop effective individualized schemes of therapeutic and preventive measures.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Clinical diagnostics of undifferentiated connective tissue dysplasia

Cited by 9 publications

References 5 publications

Connective tissue dysplasia in the genesis of cervical incompetence

Connective tissue dysplasia in the genesis of cervical incompetence

Protocols on correction of signs of undifferentiated connective tissue dysplasia using hardware and injection techniques in cosmetic patients

Correlations of cytokines, regulating the synthesis of structural macromolecules of connective tissue, in undifferentiated connective tissue dysplasia in adolescent girls

Contact Info

Product

Resources

About