Clinical economic effects of reamberin use in urgent disorders based on results of meta-analysis

Abstract

26with manufacturer's recommendations [11]. All together there were 232 cases of 3 nosologic emergency conditions proven as bound with hypoxic, energy deficit and vegetative homeostasis disregulative statuses [3,4,7,10,[13][14][15]. These emergency conditions were: acute coronary syndrome without Q but linked with arterial hypertension (ACS+AH), ischemic stroke (IS), liver resections (LR). Certified medical specialists (therapists, cardiologists, neurologists, surgeons, emergency specialists) evaluated clinical status dynamics for all the participating patients and fixed data in clinical documents. Patient data included the following informational clusters: 1). Symptoms, syndromes before and after the treatment according to clinical, laboratory, instrumental tests; 2). Drug administration (dosage for single intake and all the curse signature, the intake methods as pre os, intravenous etc.). The intake time was also under estimation, as well as the signs of coming effects/ ineffectiveness. Actual costs of medication included not only pharmacological agents, but also syringes, intravenous infusion systems etc.; 3). Marks about complications, adverse effects during the supervision period; 4). Complicated accounts of economic costs incl. medication (see p. 2), expenses of complicated medical services with hospital stay, diagnostic applications, additional complication treatment, medical specialists' fee. Web resource "Kirov pharmacy costs" allowed to appreciate the drugs' prices [19]. Economic departments of research-involved hospitals helped to assure precisely all the other expenses mentioned above. Transitory (surrogate) pathology specific markers of effectiveness served as quantitative and qualitative frequency parameters of reamberin effects. Effectiveness calculation were rates of positive clinical outcomes (% of patients with main symptoms disappear, with somatic status improvement, % of complications' number decrease during fixed time cut) in BT and BT + R groups. Statistical tools with χ 2 criteria and p<0,05 were used. The unified indicators of clinical efficiency were IAA (increase of absolute advantage), IRA (increase of relative advantage), NNT (number needed to treat -number of patients to treat traditionally during certain time for a favorable outcome comparable to a new way), OR (odds ratio -relation of improved outcome chances) and their 95% confidential intervals (95% of CI). The mathematic tool was meta-analysis calculator WinPepi published in the Internet network [1,12,20]. Sensitivity analysis [18] implied intra-and intergroup heterogeneity of indicative responses (χ 2 , p< 0,1), «expense/ efficiency» (CER) coefficient's variability range dependent of minimal and maximal entire treatment drug dosage costs. As the work's aim was to integrate data of the same treatment efficiency (with/ without reamberin additionally) in patients with emergencies like myocardium damage, acute failure of cerebral blood supply or surgical aggression, also to form the conclusion about clinical and clinic-economic (pha...

Efficiency of Structural Antigipoxants in Perioperative Period of Patients with Lower Limbs Fractures

“…Functional activity depend on muscle condition and on blood parameters mainly hemoglobin and serum albumin in all age groups [5]. Correction of metabolic stress with sodium meglumine succinate can increase patiets survivalrate functional and blood parameters after massive blood loss and other acute clinical conditions [3,4].…”