Clinical effect of combined ulinastatin and continuous renal replacement therapy on management of severe sepsis with acute kidney injury

Abstract

Purpose: To explore the effect of a combination of ulinastatin and continuous renal replacement therapy (CRRT) for the treatment of severe sepsis with acute kidney injury (SAKI Results: Levels of interleukin-6 (IL-6), tumor necrosis factor α (TNFα), serum C-reactive protein (CRP), procalcitonin (PCT), malondialdehyde (MDA), cystatin, blood urea nitrogen (BUN), prothrombin time (PT), activated partial thromboplastin time (APTT), serum creatinine (SCr) and urinary kidney injury molecule-1 (Kim-1) in the treatment group were significantly lower than those in the control group after ulinastatin treatment (p < 0.05). However, superoxide dismutase (SOD), fibrinogen (Fib) and total antioxidant capacity (T-AOC) in the treatment group were significantly higher in the control group after treatment (p < 0.05). No serious adverse drug reactions were seen in the two groups. In addition, there were no significant differences in 28-day mortality between the two groups. Conclusion: These results suggest that ulinastatin combined with CRRT effectively decreases serum levels of inflammation in SAKI patients through a mechanism involving improvement of antioxidant capacity, reduction of oxidative stress, and enhancement of renal and coagulation functions.

Ulinastatin ameliorated streptozotocin-induced diabetic nephropathy: Potential effects via modulating the components of gut-kidney axis and restoring mitochondrial homeostasis

“…The effect of UTI on kidney functions was consistent with a previous study, which found that UTI treatment improved kidney functions in patients with acute kidney injury induced by severe sepsis by significantly lowering BUN and serum creatinine levels [ 14 ]. Previous research on the effect of UTI on blood glucose levels has yielded conflicting results.…”

Improvement of Sepsis Prognosis by Ulinastatin: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…We extracted the data from 12 studies (Fang and Chen, 2005; Shao et al, 2005; Ni et al, 2008; Sung et al, 2009; Tang, 2013; Wu et al, 2013b; Karnad et al, 2014; Chen et al, 2015; Choudhuri et al, 2015; Wu et al, 2016; Fang and Zhao, 2017; Pavan Kumar Rao et al, 2017) and 1110 participants were classified into two groups to assess all-cause mortality. All-cause mortality was significantly lower in the UTI group than in the control group (OR = 0.48, 95% CI [0.35–0.66], p < 0.00001), and heterogeneity in the results was not observed (x 2 = 12.57, p = 0.37, I 2 = 13%).…”

“…We obtained the related data from eight studies (Fang and Chen, 2005; Shao et al, 2005; Jiang et al, 2006; Wang et al, 2007; Tang, 2013; Wu et al, 2013b; Chen et al, 2015; Fang and Zhao, 2017) (402 participants in two groups) to analyze the serum levels of IL-6. The serum level of IL-6 at the time of hospital admission was not different between the UTI and control groups.…”

The efficacy and safety of Tanreqing injection combined with western medicine for severe pneumonia

“…[ 14 – 16 ] It is characterized by rapid onset, rapid change of disease condition, and high fatality rate. [ 17 ] Severe pneumonia is the leading cause of death among children. [ 18 ] Severe pneumonia is common in pathogenic bacteria infection, and pulmonary infection is gradually aggravated due to unreasonable use of antibiotics and patients’ own physical factors, thus causing damage to multiple organs throughout the body [ 19 ] and developing into severe pneumonia.…”