Clinical effect of rhubarb on the treatment of chronic renal failure: A meta-analysis

Abstract

Objective: 1) To evaluate the effificacy of rhubarb in the treatment of chronic renal failure (CRF); 2) To explore the safety for rhubarb-based therapy on chronic renal failure.Methods: The randomized and semi randomized controlled trials of Rhubarb in the treatment of chronic renal failure in medical electronic databases (up to September 2021) were searched, and meta-analysis was carried out by revman 5.3 software.Results: A total of 2,786 patients were included in 34 literatures, including 1,474 cases in the treatment group and 1,312 cases in the control group. The results of meta-analysis showed that Serum creatinine (SCR) [MD = 123.57, 95% Cl (111.59, 131.96)], Blood urea nitrogen (BUN) [MD = −3.26, 95% Cl (−4.22,−2.31)], Creatinine clearance rate (CCR) [MD = 3.95, 95% Cl (−0.03, 7.93)], Hemoglobin (Hb) [MD = 7.70, 95% Cl (−0.18, 15.58)] and Uric acid (UA) [MD = −42.79, 95% CI (−66.29, −19.29)]. The total effective rate of improving symptoms and signs in chronic renal failure patients [Peto or = 4.14, 95% Cl (3.32, 5.16)].Conclusion: This systematic review and meta-analysis demonstrated that rhubarb has a positive therapeutic effect, which may provide confifidence and some theoretical reference for clinical application to a certain extent. Compared with the control group, rhubarb alone or traditional Chinese medicine compound containing Rhubarb can significantly reduce Serum creatinine, Blood urea nitrogen and Uric acid, increase Creatinine clearance rate, and improve the total effective rate of symptoms and signs. However, there is no evidence that rhubarb is more effective than the control group in increasing hemoglobin. In addition, due to the low quality of research methodology in the included literature, it is necessary to further study high-quality literature to evaluate its efficacy and safety.Systematic Review Registration:https://inplasy.com/inplasy-2021-10-0052/, identifier INPLASY2021100052.

Pharmacokinetic–pharmacodynamic modeling of the active components of Shenkang injection in rats with chronic renal failure and its protective effect on damaged renal cells

“…Presently, the traditional Chinese and Western medicine in the treatment of CRF has gradually become a clinical consensus, both of which have common features in the regulation of immunity, prevention and treatment of infection, and anticoagulation (Chen et al, 2022;Fang et al, 2023). Traditional Chinese medicine believes that CRF can be classified as "obstruction and rejection" (Guange), "consumptive disease" (Xulao), "edema" (Shuizhong), or "retention of urine" (Longbi) (Huang et al, 2023). The treatment schemes for CRF mostly focus on invigorating the spleen and tonifying kidney (Jianpiyishen), removing toxins and blood stasis (Huayuqudu), and eliminating dampness and turbidity with aromatherapy (Fanghuashizhuo) (Cao et al, 2023).…”