Clinical effect of stannous fluoride and amine fluoride containing oral hygiene products: A 4-year randomized controlled pilot study

Abstract

This 4-year randomized controlled trial (RCT) aimed at investigating whether routine home use of both a SnCl 2 /AmF/NaF-containing mouth rinse and toothpaste has a preventive effect on oral health. Fifty-four test subjects were examined in biannual intervals. The primary endpoint “dental erosion” was determined by the Basic Erosive Wear Examination (BEWE). The secondary endpoints were “saliva pH”, “dentin hypersensitivity” generated by Visual Analogue Scale (VAS), and “discoloration” measured by the Lobene Stain Index (LSI). A mixed model for repeated measures (MMRM) was used to analyze the primary endpoint “dental erosion”. Primary analysis showed a significant intervention effect of the SnCl 2 /AmF/NaF-containing test product (p 1 = 0.0242). This result was confirmed by two additional MMRM-based sensitivity analyses. Comparison of all models showed “dental erosion” values of the intervention group below values of the control group. Discoloration of the teeth was significantly higher in the intervention than in the control group at all time points. Saliva pH and dentin hypersensitivity were not significantly different between groups over four years. In summary, this RCT is the first to indicate a possible preventive effect of SnCl 2 /AmF/NaF-containing oral hygiene products on dental erosion over a follow-up period of four years.

Influence of the long-term use of oral hygiene products containing stannous ions on the salivary microbiome – a randomized controlled trial

“…This result was also confirmed by the clinical data on the oral health status demonstrated by the biannual caries assessment by the ICDAS-II-System for both groups 33 . The clinical data on erosion showed that the treatment group yielded a better result after four years with less increment in erosion 34 . In this respect the continual use of these products as a preventive measure for tooth erosion can be recommended for patients with a high risk of erosion and can be considered as contributing to oral health in general.…”

“…The study was registered at the German Clinical Trials Registry Platform (DRKS00005019, registration 2013/05/27). Previous studies have shown that endurance athletes are at a higher risk of erosive tooth wear than controls 34 . For this reason, 54 participants who performed at least five hours of endurance training per week were recruited between March and October 2013 and included in the study.…”

“…Clinical oral examinations were performed every 6 months with assessment of dental erosion (BEWE), caries index (ICDAS II) and a professional tooth cleaning at the Department of Conservative Dentistry, University Hospital Heidelberg (Heidelberg, Germany) by one blinded calibrated examiner 33,34 . For the analysis of the salivary microbiota stimulated saliva was sampled from each participant at baseline and after the three-year treatment period using sterile paraffin gum.…”

Protective Effect of Solutions Containing Polymers Associated with Fluoride and Stannous Chloride on Hydroxyapatite Dissolution

“…In high concentrations, it also forms deposits on the tooth surface, creating an Sn-rich layer, which has been shown to be more acid-resistant than pure CaF 2 [Schlueter et al, 2009a]. Unfortunately, the use of stannous ions might be associated with some drawbacks, as tooth or tongue discoloration and astringent feeling on the mucosa [Addy, 2008;Frese et al, 2019].…”

The Addition of Propylene Glycol Alginate to a Fluoride Solution to Control Enamel Wear: An in situ Study

“…So far, polyvalent fluoridated com-pounds, such as stannous fluoride (SnF 2 ) or the combination of fluoride with a stannous salt (commonly SnCl 2 ), have shown encouraging results [Ganss et al, 2008;Schlueter et al, 2009b]. However, stannous-containing formulations have been associated with some drawbacks, such as tooth staining and unpleasant taste [Frese et al, 2019].…”