Clinical effectiveness of fish oil on arterial stiffness: A systematic review and meta-analysis of randomized controlled trials

Chu, Zhenyu; Yao, Wei; Hao, Yan; Wang, Jun; Huang, Fang; Miao, Heng

doi:10.1016/j.numecd.2020.12.033

Cited by 10 publications

(6 citation statements)

References 55 publications

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“…The difference in mean Cf-PWV between the two eating patterns was small (0.2 m/s or 3%); however, this difference is similar to reductions noted for PWV in controlled feeding trials. In a recent meta-analysis of 12 randomized controlled trials (n = 1007 participants), Chu et al observed 0.148 m/s mean reduction in PWV in participants receiving fish oil supplements compared to controls (p = 0.013) [ 19 ]. Trial durations averaged 14 weeks, and participant PWV at baseline averaged ~ 8 m/s.…”

Section: Discussionmentioning

confidence: 99%

Arterial stiffness and cardiometabolic health in omnivores and vegetarians: a cross-sectional pilot study

Mayra

Johnston

2022

BMC Res Notes

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Objective Arterial stiffness is a strong predictor of cardiovascular mortality, and often precedes elevations in blood pressure. This cross-sectional pilot study examined differences in arterial stiffness, blood pressure, cardiometabolic markers, anthropometric outcomes, and inflammation in vegetarians and matched omnivores. Participants were healthy, non-smoking adults (18–65 years old) adhering to either a vegetarian/vegan or omnivore diet. Omnivores were matched to vegetarians using broad body mass index (BMI) categories. Results Arterial stiffness trended higher in omnivores versus vegetarians (7.0 ± 1.5 and 6.8 ± 1.1 m/s, respectively; p = 0.073). This trend was mainly driven by the male omnivores (p = 0.006 for gender effect and p = 0.294 for eating pattern effect). Omnivores displayed higher HDL concentrations compared to vegetarians, 63.8 ± 18.5 and 55.2 ± 16.9 mg/dL; however, total cholesterol/HDL ratio did not vary significantly between groups; p = 0.310. In men, a vegetarian eating pattern may reduce arterial stiffness; however, this benefit may be limited in women, particularly those who are premenopausal. Future research should examine arterial stiffness and cardiometabolic health outcomes in younger versus older female vegetarians, as these data can provide valuable insights on the role of plant-based eating patterns on arterial stiffness and cardiometabolic health.

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Section: Discussionmentioning

confidence: 99%

Arterial stiffness and cardiometabolic health in omnivores and vegetarians: a cross-sectional pilot study

Mayra

Johnston

2022

BMC Res Notes

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“…Siasos et al demonstrated that omega 3 fatty acids improve endothelial function and arterial elasticity, parallel to an antiinflammatory effect in smokers [49]. PWV was significantly improved especially among young persons, after a short time supplementation with low doses of fish oil, with a low DHA/EPA ratio [53]. Pase et al confirms, in his systematic review, the benefits of omega-3 fish oils for arterial stiffness, independent of blood pressure [29].…”

Section: Fatsmentioning

confidence: 94%

“…Omega-3 PUFA decreases blood pressure, improves endothelial function, exerts antioxidant, anti-inflammatory, and antithrombotic actions, delays plaque development and calcification and increases their stability [52]. Fish oil, rich in omega-3 PUFAs, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), was effective in improving peripheral arterial stiffness, but it did not affect the augmentation index [53]. The level of maternal oily fish consumption in pregnancy may influence a child's large artery development, and future cardiovascular events [54].…”

Section: Fatsmentioning

confidence: 99%

The Relationship Between Dietary Choices and Health and Premature Vascular Ageing

Mozoş

Jianu

Stoian

et al. 2021

Heart, Lung and Circulation

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The paper aims to review the available data about the main mechanisms enabling improvement or accelerating vascular ageing due to food choices, considering recent experimental and clinical data, and emphasising potential implications for clinical practice and therapy. The main food choices which will be discussed are diets rich in fruits and vegetables, the Mediterranean diet, polyunsaturated fatty acids, cocoa, caffeine, tea, meat, dairy products, sodium, and potassium intake.

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“…Another meta-analysis suggested that fish oil supplementation can reduce arterial stiffness, as indicated by carotid to femoral-pulse wave velocity (cf-PWV) and brachial to ankle-PWV (ba-PWV), especially in trials with low dosages, short duration, and low DHA/EPA ratio and between participants of young age. However, fish oil supplementation did not significantly affect the augmentation index (AIx) or AIx75 [26].…”

Section: Eicosapentaenoic Acid/arachidonic Acid Ratios (Epa/aa)mentioning

confidence: 96%

The multidimensional benefits of eicosapentaenoic acid: from heart health to inflammatory control

Nassar,

Jaffery,

Ibrahim

et al. 2023

Egypt J Intern Med

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Eicosapentaenoic acid (EPA) is an omega-3 fatty acid found in fatty fish and fish oil supplements. Over the past few decades, research has suggested that EPA has various potential health benefits, particularly for heart health.EPA has been associated with reduced inflammation, improved cholesterol levels, and reduced blood pressure, all of which can contribute to a lower risk of heart disease. Additionally, EPA has been found to reduce the risk of blood clots, which can lead to heart attacks and strokes. This comprehensive review article aims to summarize the current state of knowledge regarding the potential health benefits of EPA. We focus on its effects on cardiovascular health, inflammation, atherosclerotic plaques, blood clots, diabetes, obesity, and cancer. Finally, we provide an overview of the recommended daily dose of EPA for optimal health benefits.This review highlights the importance of EPA in promoting overall health and well-being and provides insights into its potential therapeutic applications.

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Clinical effectiveness of fish oil on arterial stiffness: A systematic review and meta-analysis of randomized controlled trials

Cited by 10 publications

References 55 publications

Arterial stiffness and cardiometabolic health in omnivores and vegetarians: a cross-sectional pilot study

Arterial stiffness and cardiometabolic health in omnivores and vegetarians: a cross-sectional pilot study

The Relationship Between Dietary Choices and Health and Premature Vascular Ageing

The multidimensional benefits of eicosapentaenoic acid: from heart health to inflammatory control

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