Clinical efficacy analysis of butylphthalide combined with urinary kallidinogenase in treating chronic cerebral circulatory insufficiency

Abstract

Objective To investigate the clinical effect of butylphthalide combined with urinary kallidinogenase in the treatment of chronic cerebral circulatory insufficiency (CCCI). Methods A total of 102 CCCI patients admitted to our hospital from October 2020 to December 2021 were retrospectively enrolled in this study. According to the different therapeutic strategy, the patients were divided into combined group (treated with butylphthalide combined with urinary kallidinogenase, n = 51) and butylphthalide group (treated with butylphthalide, n = 51). Blood flow velocity and cerebral blood flow perfusion before and after treatment between the two groups were compared. The clinical efficacy and adverse events of the two groups were analyzed. Results After treatment, the effective rate of the combined group was significantly higher than the butylphthalide group ( p = .015). Before treatment, the blood flow velocity of middle cerebral artery (MCA), vertebral artery (VA), basilar artery (BA) were comparable ( p > .05, respectively), while after treatment, the blood flow velocity of MCA, VA, and BA in combined group were faster than those in butylphthalide group ( p < .001, respectively). Before treatment, the relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), relative mean transmit time (rMTT) of the two groups were comparable ( p > .05, respectively). After treatment, rCBF and rCBV in combined group were higher than those in butylphthalide group ( p < .001, respectively), and rMTT in combined group was lower than that in butylphthalide group ( p = .001). The rate of adverse events in the two groups were comparable ( p = .558). Conclusion Butylphthalide combined with urinary kallidinogenase can improve the clinical symptoms of CCCI patients, and the effect is promising, which is worthy of clinical application.

Recurrent Cerebral Infarction Due to Moyamoya Disease Complicated With Systemic Lupus Erythematosus

“…Since both mechanisms coexist in most patients, a combination of immunosuppressive and anticoagulant and/or antiplatelet therapy can be contemplated. Butylphthalide, urinary kallidinogenase, statins, barbiturates, antipsychotics, and antianxiety medication should be prescribed according to the patient’s condition 18,25,27 . In this case, the patient was treated with the aforementioned medicines; muscle strength of the left limb improved significantly, and no recurrent stroke event was noted during the 6 month follow-up.…”