Clinical Efficacy and Safety of Zoledronic Acid Combined with PVP/PKP in the Treatment of Osteoporotic Vertebral Compression Fracture: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Sun, Yan; Ma, Hu; Yang, Feng; Tang, Xiuwen; Yi, Ping; Tan, Mingsheng

doi:10.1155/2021/6650358

Cited by 16 publications

(11 citation statements)

References 43 publications

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“…If PKP is performed by balloon expansion, the height of the injured vertebral body can be better restored, and the cancellous bone around the left cavity can be compacted to form an artificial barrier to prevent cement leakage and reduce the injection of bone cement. However, from a biomechanical point of view, References [12,13] found that cement-induced increase in vertebral stiffness increases the risk of fracture of adjacent vertebrae. In addition, vertebral bone cement increases the likelihood of secondary Kummell's disease [14,15].…”

Section: Discussionmentioning

confidence: 99%

Clinical Evaluation of Unilateral Vertebroplasty for OVCF

Wen

Zhang

Jiang

et al. 2022

Emergency Medicine International

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Objective. To investigate the clinical evaluation of unilateral vertebroplasty for OVCF. Methods. A retrospective analysis was performed on 60 patients treated with PVP from January 2020 to December 2021. Patients were divided into two groups according to the treatment method, 30 patients in the PVP group received PVP and 30 patients in the PCVP group received PCVP. The VAS score, ODI score, bone cement dosage, and leakage were compared between the two groups preoperatively, immediately postoperatively, and 7 and 30 days postoperatively. Results. VAS scores in the PCVP and PVP groups before, immediately after, and 7 days after surgery were P > 0.05 , and the difference was not statistically significant; ODI score in group 1 before surgery was not statistically significant ( P > 0.05 ); bone cement injection volume in the PVP group was significantly higher than that in the PCVP group ( P < 0.05 ), and the difference was statistically significant; the difference in bone cement leakage between the two groups was not statistically significant ( P > 0.05 ). Conclusion. Under the same puncture conditions, the PCVP group used the method of injection while retreating to achieve a better bone cement dispersion effect by using less bone cement and achieving uniform dispersion of bone cement. It can relieve the patients’ back pain and improve the back function.

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Section: Discussionmentioning

confidence: 99%

Clinical Evaluation of Unilateral Vertebroplasty for OVCF

Wen

Zhang

Jiang

et al. 2022

Emergency Medicine International

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“…In general, general or local bone pain may occur in the normal population with bone mass loss of more than 12%. For elderly patients, the degree of osteoporosis is generally more serious than that caused by other reasons [ 13 ]. The vertebral body strength of patients is significantly reduced, compressive deformation may occur, the spine loses its normal shape, and fatigue and even recovery of the muscles near the spine, such as erector spine, may cause obvious pain symptoms.…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Analysis of the Effect of Percutaneous Cone Shaping in Patients with Osteoporotic Vertebral Fractures

Fan

Bao

et al. 2022

Contrast Media & Molecular Imaging

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Objective. To study and analyze the clinical effect of percutaneous cone shaping in patients with osteoporotic vertebral fractures. Methods. A total of 100 patients with vertebral osteoporotic fracture treated in our hospital from June 2019 to September 2020 were selected, and there were 50 patients with vertebral osteoporotic fracture in each group. Patients could be divided into two groups according to different treatment plans: one group was vertebroplasty patients for group A, and the other group was nonsurgical treatment patients for group B. The incidence of complications during treatment and follow-up was recorded in both groups. Results. According to a study, both groups of patients completed the treatment and follow-up, no patients lost to follow-up or death, the VAS scores and ADL scores of patients before treatment were higher, and there was no significant difference at baseline ( P > 0.05 ). After different treatment methods, the VAS score and ADL score of group A showed good improvement after treatment compared with that before treatment, and there were certain differences within the group, with statistical significance ( P < 0.05 ). Intragroup comparison. The VAS scores of group B at 1 week, 1 month, 3 months, and 12 months after treatment were all superior to those before treatment, and the ADL scores at 1 month, 3 months, and 12 months after treatment were all superior to those before treatment, with statistically significant differences ( P < 0.05 ). VAS scores and ADL scores showed good improvement 1 day, 1 week, and 1 month after treatment compared with those before treatment. However, there were no significant differences in the VAS score and ADL score between the two groups at 3 and 12 months after treatment. The incidence of complications in group A is lower than that in group B. The incidence of complications in group A is as follows: there was 1 case of recurrent vertebral fracture and 1 case of urinary tract infection, and the overall incidence of complications was 4.00%. In group B, there were 1 case of recurrent fracture, 3 cases of bedsore, 2 cases of urinary tract infection, and 2 cases of pulmonary infection, and the incidence of total complications was 16.00%. After comparison between groups, there was a significant difference in the incidence of complications between the two groups, and the difference was statistically significant ( P < 0.05 ). Conclusions. Percutaneous cone plasty can provide rapid relief of pain symptoms in patients with osteoporotic vertebral fractures and significantly improve their daily activities. However, there was no significant difference in long-term recovery from group B. In terms of the incidence of complications, the incidence of complications in group A was lower than that in group B after certain treatment.

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“…In today's aging society, osteoporotic vertebral compression fractures has become more common in clinical practice [14,15]. OVCF refers to spinal fractures that occur with or without minor trauma due to decreased bone density and bone mass caused by osteoporosis as well as decreased bone strength, mainly manifesting as pain and limited movement in the chest, waist and back with or without neurological symptoms in the lower extremities [16].…”

Section: Discussionmentioning

confidence: 99%

Study on the Therapeutic Effect of ESPB for Patients Undergoing Percutaneous Vertebroplasty

Peng

Jiang

2022

Preprint

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Objective To compare the difference oftherapeutic effect between percutaneous vertebroplasty (PVP)alone and PVP + Erector spinal plane block (ESPB) in the treatment of osteoporotic vertebral compression fracture (OVCF). Methods After admission, 100 patients with osteoporotic vertebral compression fracture were randomly divided into PVP group (control group) and PVP+ESPB group (observation group) by lottery with 50 patients in each group.The visual analog pain scores (VAS) and oswestry disability index (ODI) of each group were compared before surgery, 2 hours after surgery and at the time of hospital discharge. The operation time, filling volume of intraoperative bone cement, intraoperative bloodloss, and surgery cost of each group were compared.Theearly postoperative ambulation time and early postoperative defecation (stool) time ofeach group were compared to explore the difference.Results The PVP+ESPB group had better visual analog pain scores (VAS) and oswestry disability index (ODI) at 2 hours after surgery and at the time of hospital discharge, and better early postoperative ambulation timeand early postoperative defecation (stool) timethan the PVP group (p<0.05). There were no differences in the visual analog pain scoresand oswestry disability index before surgery, operative time, filling volume of intraoperative bone cement, intraoperative blood loss, and surgery cost between the two groups, and no complications occurred between the two groups after surgery and at the time of hospital discharge. Conclusion PVP+ESPB for OVCF is associated with lower VAS, more significant pain relief, and lower oswestry disability index in patients after surgery than PVP alone for OVCF, and patients are able to engage in ambulation time earlier. Meanwhile, PVP+ESPB promotes recovery of intestinalfunction and improves patients’ quality of life so as tocontribute toquick recovery.

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Clinical Efficacy and Safety of Zoledronic Acid Combined with PVP/PKP in the Treatment of Osteoporotic Vertebral Compression Fracture: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Cited by 16 publications

References 43 publications

Clinical Evaluation of Unilateral Vertebroplasty for OVCF

Clinical Evaluation of Unilateral Vertebroplasty for OVCF

[Retracted] Analysis of the Effect of Percutaneous Cone Shaping in Patients with Osteoporotic Vertebral Fractures

Study on the Therapeutic Effect of ESPB for Patients Undergoing Percutaneous Vertebroplasty

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