Clinical efficacy assessment of the albendazole–ivermectin combination in lambs parasitized with resistant nematodes

Entrocasso, C.; Álvarez, Luis Ignacio Ortega; Manazza, J.; Lifschitz, Adrián Luis; Borda, Bernadett; Virkel, G.; Mottier, L.; Lanusse, Carlos

doi:10.1016/j.vetpar.2008.04.015

Cited by 55 publications

(41 citation statements)

References 25 publications

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“…Nos rebanhos Angélica e São Gabriel do Oeste, o resultado foi inverso: a associação não reduziu a contagem de OPG para ser considerada eficaz, mas a redução foi maior do que aqueles das bases em formulações simples. Entrocasso et al (2008) também relataram diferenças de redução de OPG entre a utilização de bases, seja separadamente ou em associação. Frente à diferença dos resultados e do contido na literatura, há necessidade de esclarecer se há ou não sinergismo das moléculas ou se estes foram resultados casuais.…”

Section: Quadro 4 Percentuais Da Condição De Resistência (R) Baixa unclassified

Resistência anti-helmíntica de nematóides gastrintestinais em ovinos, Mato Grosso do Sul

Sczesny-Moraes

Bianchin²,

Silva³

et al. 2010

Pesq. Vet. Bras.

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ABSTRACT.-Sczesny-Moraes E.A., Bianchin I., Silva K.F., Catto J. Among the methods of control of gastrointestinal worms in sheep, the use of chemicals is the most common. However, the continued, and indiscriminate, use of these products has selected populations of resistant helminths to anthelmintics, a phenomenon reported in the whole world. This study aimed to identify the species of gastrointestinal parasites and diagnose the status of anthelmintic resistance in sheep in the State of Mato Grosso do Sul Brazil. Feacal egg count reduction tests (FECRT) were performed in flocks of sixteen farms, and the seven formulations used contained the following pharmacological bases: Albendazole, Ivermectin, Levamizol, Trichlorfon, Moxidectin, Closantel and one containing the first three in association. The species identified at necropsy, in adult sheep, were: Haemonchus contortus, Trichostrongylus colubriformis, Cooperia curticei, C. punctata, C. pectinata and Oesophagostomum columbianum, in order of prevalence. The formulations containing Albendazole and Ivermectin did not show efficacy in reducing the EPG in the flocks tested, with average reductions of 0.7 and -19.6%, respectively. Closantel presented an average efficacy of 6.7%; Levamisolee, Moxidectin and Trichlorfon, 28.7, 26.8 and 65% respectively, the combination of three bases (Albendazole, Ivermectin and Levamizol), an average efficacy of 55.8 %. The average percentages of infective larvae recovered in the faecal cultures, pre and post treatment were similar, indicating that resistance to the bases tested is present in all species cited, to a greater or lesser degree. The two genera predominantly resistant are Haemonchus sp., with 86.9%, followed by Trichostrongylus sp., with an average of 47.5%, Strongyloides sp. 33.6%, Oesophagostomum sp.

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Section: Quadro 4 Percentuais Da Condição De Resistência (R) Baixa unclassified

Resistência anti-helmíntica de nematóides gastrintestinais em ovinos, Mato Grosso do Sul

Sczesny-Moraes

Bianchin²,

Silva³

et al. 2010

Pesq. Vet. Bras.

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“…Gastrointestinal parasitism is one of the main sanitary problems affecting yield in cattle production systems with consequences ranging from weight loss without clinical manifestations to death (Ames et al 1969, Entrocasso 1994, Entrocasso et al 2008. Ostertagia ostertagi, Cooperia spp., Trichostrongylus axei and Haemonchus contortus are the most important gastrointestinal parasites in calves, but their prevalence and importance vary in different regions of Argentina (Fiel & Steffan 1994, Caracostantogolo et al 2005.…”

Section: Introductionmentioning

confidence: 99%

Impact of ivermectin-resistant gastrointestinal nematodes in feedlot cattle in Argentina

et al. 2012

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The aim was to evaluate for 75 days the impact on production of the remaining burden of ivermectin (IVM)-resistant parasites in naturally infected feedlot calves. The herds came from tick-infested areas of cattle breeding where the systematic use of IVM to control tick increases the gastrointestinal parasites resistant to this drug. This investigation was carried out in two commercial feedlots in Buenos Aires province. In feedlot A, two groups of 35 animal each received IVM 1% and the other received ricobendazole (RBZ) 10% respectively. The same was done in feedlot B. On day 0, two groups of 35 animals were made in feedlots A and B. Fecal samples were taken on days 0, 22, 54 and 75 pos-treatment (PT), and body weight was registered, from each animal. Fecal samples were processed for individual count of eggs per gram (EPG) and pooled fecal culture was carried out for identiϐication of the parasite genus in each sampling. Fecal egg count reduction test (FECR) was calculated on day 22 PT. The study design used was a totally randomized block, with commercial feedlot and sex as block variables. For data analysis, a mixed model of the SAS statistical program was used. The FECR average on day 22 was 28.4% in the IVM group, and 94,2 % in the RBZ group . From this date on, signiϐicant differences in EPG were kept until day 54. EPG counts were only equal near the end of the trial, on day 75 (p=0.16). In both commercial feedlots, especially in the IVM group, Cooperia spp. was the most prevalent parasite in the fecal cultures. Signiϐicant differences in weight (P<0.01) on post-treatment day 75 was found between the average weight in the RBZ and the IVM group (246 vs. 238 kg respectively), what means a difference of 8.3% in gains. The importance for production in the antiparasite failure treatment in commercial feedlots was demonstrated, and the need of pos-treatment controls to evaluate the efϐicacy of the antiparasitic administered is emphasized.

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“…Perlakuan kombinasi IVM dan ABZ terjadi penurunan jumlah telur Ostertagia sampai hari ke-28. Penurunan jumlah telur Ostertagia setelah diberi kombinasi IVM dan ABZ dilaporkan terjadi pada hari ke-13 (Entrocasso et al 2008).…”

Section: Faecal Egg Counts (Fec)unclassified

“…Menurut Prichard et al (1980), resistensi silang dapat terjadi ketika suatu populasi dapat melawan antihelminth dalam kelompok kimia yang berbeda dengan mekanisme yang berbeda. Perlakuan kombinasi dapat dinyatakan memiliki efek sinergis apabila efektivitas kombinasi lebih tinggi daripada efektivitas obat yang diberikan secara terpisah (Entrocasso et al 2008). Hasil penelitian menunjukkan bahwa efektivitas kombinasi antihelminth lebih tinggi daripada efektivitas ABZ 1 dosis.…”

Section: Perlakuan Kombinasi (Ivermectin ½ Dosis + Albendazole ½ Dosis)unclassified

Effectiveness of Ivermectin and Albendazole Against Ostertagia on Sheep in Bogor, Indonesia

Puspitasari¹,

Sulistiawati²,

Basar³

et al. 2015

JIPI

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ABSTRAKPemberian antihelminth setengah dosis merupakan metode sederhana untuk deteksi dini terjadinya resistensi parasit yang menginfeksi ruminansia kecil. Ketika kegagalan antihelminth secara tunggal pada domba asli dari Indonesia, kombinasi antihelminth dari kelas kimia dengan mekanisme yang berbeda sebagai salah satu strategi alternatif pengendalian parasit. Penelitian ini membandingkan efektivitas ivermectin (IVM) dan albendazole (ABZ) baik yang diberikan secara terpisah dengan pemberian satu dan setengah dosis maupun dikombinasikan pada domba secara yang alami terinfeksi Ostertagia. , and control groups. The treatment effectiveness was determined using the Faecal egg count reduction (FECR) on before and after 7, 14, 21, 28, 35, and 42 days of treatment. FECR of half-dose IVM, full-dose IVM, half-dose ABZ, full-dose ABZ, and both combined ranged from 78100, 96100, -7189, -52164, and 54100, respectively. The results showed that full-dose IVM was the most effective to against Ostertagia until 42 days and followed the combined that effective until 28 days. Half-dose and full-dose ABZ weren't effective to against Ostertagia.

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Clinical efficacy assessment of the albendazole–ivermectin combination in lambs parasitized with resistant nematodes

Cited by 55 publications

References 25 publications

Resistência anti-helmíntica de nematóides gastrintestinais em ovinos, Mato Grosso do Sul

Resistência anti-helmíntica de nematóides gastrintestinais em ovinos, Mato Grosso do Sul

Impact of ivermectin-resistant gastrointestinal nematodes in feedlot cattle in Argentina

Effectiveness of Ivermectin and Albendazole Against Ostertagia on Sheep in Bogor, Indonesia

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