Clinical efficacy of carprofen as an adjunct to the antibacterial treatment of bovine respiratory disease

Abstract

A clinical trial was undertaken to investigate the efficacy of a single dose of carprofen (CPF) in the treatment of bovine respiratory disease in cattle. Tilmicosin was used as a basal treatment in all animals. Six hours after dosing, body temperature and respiratory rates in animals treated with CPF-tilmicosin had decreased and were significantly lower than in the animals treated with tilmicosin alone (P < 0.05). Over the period of clinical observation, CPF-tilmicosin treatment produced a clinical resolution of the pneumonia similar to treatment with tilmicosin alone. However, it is significant from an animal welfare perspective that over the period of the study after treatment, CPF-tilmicosin therapy produced significantly greater symptomatic improvement than tilmicosin.

Antimicrobial synergy between carprofen and doxycycline against methicillin-resistant Staphylococcus pseudintermedius ST71

“…Carprofen is a non-steroidal anti-inflammatory drug (NSAID) for veterinary treatment of inflammation and pain management. It has earlier been reported to have a clinical effect when used in combination with tilmicosin for antimicrobial therapy of bovine respiratory disease [ 21 ]. DOX is the most widely used tetracycline in small animal practice due to low systemic toxicity [ 22 ] and higher antimicrobial activity compared to TET [ 12 ].…”

Clinical efficacy of diclofenac sodium and flunixin meglumine as adjuncts to antibacterial treatment of respiratory disease of calves

“…8 Many antibacterial agents have been approved for use in BRD, including tylosin, tilmicosin, enrofloxacin, danofloxacin, ceftiofur, sulfadimethoxine, amoxycillin/clavulanic acid, oxytetracycline and florfenicol. 4,7,[12][13][14] Repeated administration of any one of these products for several days is required to achieve therapeutic success. 4 Tulathromycin has been recently developed specifically for singledose parenteral administration in cattle and pigs to treat bacterial respiratory disease.…”

“…Flunixin meglumine has been extensively used, as it was the first licensed NSAID in the early 1980s 4 . Other NSAIDs include carprofen, ketoprofen and meloxicam, which have been used in conjunction with different antibiotic agents in the treatment of BRD 5,7–9 . Diclofenac sodium is a new NSAID for use in cattle and pigs, 10 but to our knowledge there is no published study of the addition of diclofenac sodium in the treatment of BRD.…”

“…4 Other NSAIDs include carprofen, ketoprofen and meloxicam, which have been used in conjunction with different antibiotic agents in the treatment of BRD. 5,[7][8][9] Diclofenac sodium is a new NSAID for use in cattle and pigs, 10 but to our knowledge there is no published study of the addition of diclofenac sodium in the treatment of BRD. The aim of this study was to compare the clinical efficacy of a single dose of diclofenac sodium versus three doses of flunixin meglumine in improving the treatment of BRD of calves.…”

Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves

“…A combination of oxytetracycline with the NSAIDs flunixin and tolfenamic acid provided greater clinical efficacy than oxytetracycline alone in field cases of calf pneumonia (Deleforge et al ., ; Doherty et al ., ; Keita et al ., ). Moreover, Elitok and Elitok () demonstrated a clinical benefit of carprofen when used as an adjunct to antimicrobial therapy with tilmicosin in bovine respiratory disease. The improvement in several respiratory signs and the attenuation of body temperature rise were greater in calves receiving carprofen in addition to tilmicosin.…”