Clinical efficacy of hyaluronic acid in post-extraction sockets of impacted mandibular third molar

Abstract

Background and Objectives: Pain and swelling are the most common complications that occur after surgical removal of impacted third molar. Aim of this study to evaluate the effectiveness of local hyaluronic acid (HA) administration to surgically remove impacted third molar sockets to evaluate pain and swelling. Materials and Methods:A comparative study included 50 healthy patients were subdivided into two equal sub group, aged 18-35 years with impacted lower third molars type of impaction (class II; position B according to Pell-Gregory classification). The procedure has been performed under local anesthesia. In the study group, 0.8% HA (Gengigel®) was applied in the post-extraction sockets of third molars and in the control group nothing was applied to the extraction sockets of third molars. Pain and swelling were evaluated with a visual analogue scale (VAS). Assessments were made on 1st, 2nd, 3th, 4th, 5 th , 6 th , 7 th days after surgery.Results: Statistically significant difference was detected for the pain values between the two treatment groups in different days of the study (p < 0.05). The swelling scores of the hyaluronic acid group were significantly lesser than those of the control group in day 1 (p = 0.008), day 3 (p = 0.006), and day 4 (p = 0.036). In the other days, the scores were less but the differences were not significant.Conclusion: hyaluronic acid appears to offer a beneficial effect in the management of pain and swelling during the immediate postoperative period following impacted third molar surgery.

The Influence of the Hyaluronic Acid Gel on the Postoperative Sequelae following Surgical Removal of the Impacted Mandibular Third Molar in Comparison with the A-PRF: A Randomized Controlled Trial

“…This study showed that pain significantly decreased in both HA and A-PRF groups compared to the control group. These results agreed with several previous studies demonstrating the effectiveness of HA gel or A-PRF in reducing postoperative pain [ 1 , 16 , 17 ].…”

“…In this study, the swelling began immediately after surgical removal of the impacted mandibular third molar and gradually increased to reach its maximum degree on the first and second postoperative days, then gradually subsided on the third or fourth postoperative days, and this agreed with many previous studies [ 26 – 28 ]. This study showed a statistically significant reduction in facial swelling in both the HA and A-PRF groups compared to the control group, which agrees with previous studies [ 17 , 18 , 20 ], with no statistically significant difference between HA and A-PRF groups in all postoperative days.…”

Hyaluronic acid addition to collagen reduces the trismus and swelling after surgical extraction of impacted lower third molars: A Split-Mouth, randomized controlled study

“…The literature offers several studies on hyaluronic acid's remarkable attributes in terms of biocompatibility, biodegradability, and low cost (21); however, no study assesses these effects when combined with another material after surgical extractions.…”

“…Nariman et al concluded that 0.8% HA application in the post-extraction sockets of third molars appears to reduce swelling scores which were evaluated daily in the rst week by a visual analogue scale (VAS) with a statistically signi cant difference on day one, day three and day four but in the other days, the scores were less in HA group, but the differences were not signi cant (21).…”