Clinical efficacy of single and multiple applications of antimicrobial photodynamic therapy in periodontal maintenance: A systematic review and network meta-analysis

Ramanauskaitė, Eglė; Moraschini, Vittório; Mačhiulskienė, Vita; Sculean, Anton

doi:10.1016/j.pdpdt.2021.102435

Cited by 21 publications

(18 citation statements)

References 43 publications

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“…PDI can slow down the growth of microorganisms, viruses and other organisms in food by releasing ROS, and even eliminate them. Although this PDI method has been widely used in the medical field, such as killing tumor cells and treating periodontal disease ( Ramanauskaite et al, 2021 ), it is still less studied in the food field, therefore, it is of great significance to apply it in the food industry. In contrast to traditional pasteurization methods, PDI minimizes the changes in nutritional and sensory properties and meets the growing demand of consumers for microbiologically safe foods without chemical additives.…”

Section: Application Of Pdi In Foodmentioning

confidence: 99%

The application of photodynamic inactivation to microorganisms in food

et al. 2021

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Section: Application Of Pdi In Foodmentioning

confidence: 99%

The application of photodynamic inactivation to microorganisms in food

et al. 2021

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“…Nonetheless, certain aspects, such as the duration of irradiation, choice of photosensitizer, and standardization of parameters, require further establishment. Furthermore, Ramanauskaite et al [ 37 ] published a systematic review and network meta-analysis on PDT in periodontal maintenance. The conclusions drawn by Ramanauskaite et al highlighted that both single and multiple additional applications of PDT following SRP led to a notable reduction in bleeding on probing (BOP) compared to scaling and root planing alone.…”

Section: Discussionmentioning

confidence: 99%

Photodynamic Therapy with Tolonium Chloride and a Diode Laser (635 nm) in the Non-Surgical Management of Periodontitis: A Clinical Study

Mobadder

Namour

Grzech‐Leśniak

2023

JCM

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This study aimed to evaluate the efficacy of photodynamic therapy (PDT) using tolonium chloride and a 635 nm diode laser as an adjunct to non-surgical periodontitis treatment, specifically scaling and root planing (SRP) alone. A total of 32 patients with a pocket probing depth > 5 mm were included in the study. Among them, 16 patients underwent SRP alone (control group), and the remaining 16 patients received SRP along with PDT (study group). The PDT procedure utilized a 635 nm diode laser (Smart M, Lasotronix, Poland) and tolonium chloride. Clinical periodontal parameters, such as the plaque index (PI), bleeding on probing (BOP), gingival recession (GR), probing pocket depth (PPD), and clinical attachment loss (CAL), were assessed before treatment (T0) and at 3 months after treatment (T3). At T3, both groups demonstrated a significant reduction in the PI, BOP, PD, and CAL compared to T0. The SRP + PDT group displayed a significant reduction in PPD (3.79 mm ± 0.35) compared to the SRP alone group (4.85 mm ± 0.42) at T3. Furthermore, the SRP + PDT group exhibited a significant reduction in CAL (5.01 ± 0.81) compared to the SRP group (5.99 ± 1.08) at T3. Within the study’s limitations, it was concluded that PDT, with tolonium chloride and a 635 nm diode laser, significantly contributed to the non-surgical treatment of periodontitis.

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“…These studies found that the treatment group with additional PDT significantly reduced the expression levels of P. gingivalis, F. nucleatum, 80,105 A. actinomycetemcomitans, T. forsythia, 100 T. denticola, 76 P. intermedia, 106 Eubacterium nodatum, and Eikenella corrodens compared with the group that only performed SRP. 80,87,107,108 Some reports also show that PDT failed to demonstrate additional bacteriological benefits of P. gingivalis, A. actinomycetemcomitans, T. forsythia, and T. denticola in periodontitis patients 74,109,110 (Table 2).…”

Section: Bacterial Composition In the Dental Plaque After Pdt-assiste...mentioning

confidence: 99%

Photodynamic therapy in periodontitis: A narrative review

Nie,

Zhang,

Pathak

et al. 2024

Photoderm Photoimm Photomed

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BackgroundPeriodontitis, a chronic infectious disease, is primarily caused by a dysbiotic microbiome, leading to the destruction of tooth‐supporting tissues and tooth loss. Photodynamic therapy (PDT), which combines excitation light with photosensitizers (PS) and oxygen to produce antibacterial reactive oxygen species, is emerging as a promising adjuvant treatment for periodontitis.MethodsThis review focuses on studies examining the antibacterial effects of PDT against periodontal pathogens. It also explores the impact of PDT on various aspects of periodontal health, including periodontal immune cells, human gingival fibroblasts, gingival collagen, inflammatory mediators, cytokines in the periodontium, vascular oxidative stress, vascular behavior, and alveolar bone health. Clinical trials assessing the types of PSs and light sources used in PDT, as well as its effects on clinical and immune factors in gingival sulcus fluid and the bacterial composition of dental plaque, are discussed.ResultsThe findings indicate that PDT is effective in reducing periodontal pathogens and improving markers of periodontal health. It has shown positive impacts on periodontal immune response, tissue integrity, and alveolar bone preservation. Clinical trials have demonstrated improvements in periodontal health and alterations in the microbial composition of dental plaque when PDT is used alongside conventional treatments.ConclusionsPDT offers a promising adjunctive treatment for periodontitis, with benefits in bacterial reduction, tissue healing, and immune modulation. This article highlights the potential of PDT in periodontal therapy and emphasizes the need for further research to refine its clinical application and efficacy.

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Clinical efficacy of single and multiple applications of antimicrobial photodynamic therapy in periodontal maintenance: A systematic review and network meta-analysis

Cited by 21 publications

References 43 publications

The application of photodynamic inactivation to microorganisms in food

The application of photodynamic inactivation to microorganisms in food

Photodynamic Therapy with Tolonium Chloride and a Diode Laser (635 nm) in the Non-Surgical Management of Periodontitis: A Clinical Study

Photodynamic therapy in periodontitis: A narrative review

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