Clinical Efficacy of Tonic Traditional Chinese Medicine Injection on Acute Cerebral Infarction: A Bayesian Network Meta‐Analysis

Abstract

Western medicine (WM) has certain limitations in terms of treating acute cerebral infarction (ACI), while tonic traditional Chinese medicine injections (TCMIs) have been shown to have obvious clinical effects as an adjunct to WM for ACI. However, most randomized controlled trials (RCTs) to date have not performed direct comparisons of efficacy among tonic TCMIs. This study designed a Bayesian network meta-analysis (NMA) to explore the therapeutic effect of tonic TCMIs on ACI. A comprehensive search of RCTs of TCMIs combined with WM for ACI was conducted using electronic databases for studies dated from the start date of each database until February 2020. Stata 13.0 and ADDIS 1.16.7 software were used to plot and analyze the data. Sixty-six RCTs with a total of 5,989 patients involving 7 kinds of tonic TCMIs were included. Among TCMIs, Shenfu injection (SFI) + WM ranked first in terms of improving clinical efficacy and the activities of daily living (ADLs) rating and reducing interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels. While Ciwujia injection (CI) + WM was the best choice for reducing neurological impairment and the high-cut viscosity of whole blood (HCV). Shenmai injection (SI) + WM had the greatest effects in terms of decreasing the levels of low-cut viscosity of whole blood (LCV), fibrinogen (FIB), and plasma viscosity (PV). Based on the cluster analysis of the clinical efficacy and the neurological impairment, CI + WM and Shenqifuzheng (SQI) + WM were the best options for treating ACI. With respect to adverse drug reactions (ADRs), 35 RCTs did not monitor ADRs during treatment. In conclusion, tonic TCMIs could assist WM in benefiting patients with ACI. However, due to the limitations of the current study, strict monitoring of ADRs and data from high-quality RCTs will be required in future to verify the advantage of TCMIs.

[Retracted] Meta‐Analysis of the Relationship between the Prognosis of Acute Cerebral Infarction Intravenous Lysis and Cerebral Microbleeds Based on Intelligent Medical Care

“…In Meng et al's study, a meta-analysis was conducted on clinical diagnosis and treatment factors and cerebral microbleeds of ACI intravenous thrombolysis, and the related factors were obtained [ 9 ]. Zhou et al could reduce the factors of cerebral microbleeds after ACI intravenous thrombolysis through Bayesian meta-analysis [ 10 ]. Meta-analysis based on intelligent medical can well study the relationship between ACI intravenous thrombolysis and cerebral microbleeds, but the intelligent medical technology used is not optimal.…”

Edaravone Combined with Clopidogrel Is Beneficial to Improve Efficacy, Neurological Impairment, and Life Function in Acute Cerebral Infarction Patients

“…Acute cerebral infarction (ACI) is an ischemic disease caused by cerebral vascular occlusion or stenosis, which can lead to brain injury and neurological deficit [1]. It has extremely high mortality, disability, and morbidity [2].…”

An Ethnopharmaceutical Study on the Hypolipidemic Formulae in Taiwan Issued by Traditional Chinese Medicine Pharmacies

“…The active ingredients of sweet medicinal materials are carbohydrate, amino acids, and vitamins ( Zhang and Liu, 2015 ), possessing tonifying and replenishing effects ( Zhang J. Y. et al, 2016 ). Tonifying and replenishing properties of medicinal materials can decrease blood viscosity and help in the treatment of acute cerebral infarction ( Zhou D. et al, 2020 ). In addition, these can regulate neurotransmitters, such as serotonin and norepinephrine, to treat central nervous system diseases ( Zhang X. et al, 2018 ).…”