Clinical efficacy of zinc supplementation in improving antioxidant defense system: A comprehensive systematic review and time-response meta-analysis of controlled clinical trials

Faghfouri, Amir Hossein; Zarezadeh, Meysam; Aghapour, Baharak; Izadi, Azimeh; Rostamkhani, Helya; Majnouni, Amin; Abu‐Zaid, Ahmed; Varkaneh, Hamed Kord; Ghoreishi, Zohreh; Ostadrahimi, Alireza

doi:10.1016/j.ejphar.2021.174243

Cited by 12 publications

(7 citation statements)

References 44 publications

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“…However, other authors negatively related serum Zn to GPx and positively to SOD and found no significant relationship with CAT and MDA content, whereas serum Cu content positively relates to GPx and negatively relates to SOD and CAT; no significant relationship with MDA was found [ 52 ]. It has been described how Zn supplementation increases SOD activity but has no effect on GPx activity [ 53 ]. In chickens supplemented with zinc sulfate or zinc oxide nanoparticles, no liver increases in the gene expression of SOD, CAT, GST, GPx and NQO1 have been found [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Sánchez-González

Moreno

Aranda

et al. 2022

Biology

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Our aim was to examine whether vanadium (IV) corrects alterations in zinc, copper and manganese homeostasis, observed in streptozotocin-induced hyperglycemic rats, and whether such changes are related to divalent metal transporter 1 (DMT1) mRNA expression, and antioxidant and proinflammatory parameters. Four groups of Wistar rats were examined: control; hyperglycemic (H); hyperglycemic treated with 1 mg V/day (HV); and hyperglycemic treated with 3 mg V/day (HVH). Vanadium was supplied in drinking water as bis(maltolato)oxovanadium(IV) for five weeks. Zinc, copper and manganese were measured in food, excreta, serum and tissues. DMT1 mRNA expression was quantified in the liver. Hyperglycemic rats showed increased Zn and Cu absorption and content in the liver, serum, kidneys and femurs; DMT1 expression also increased (p < 0.05 in all cases). HV rats showed no changes compared to H rats other than decreased DMT1 expression (p < 0.05). In the HVH group, decreased absorption and tissular content of studied elements (p < 0.05 in all cases) and DMT1 expression compared to H (p < 0.05) were observed. Liver zinc, copper and manganese content correlated positively with glutathione peroxidase activity and negatively with catalase activity (p < 0.05 in both cases). In conclusion, treatment with 3 mg V/d reverted the alterations in zinc and copper homeostasis caused by hyperglycemia, possibly facilitated by decreased DMT1 expression.

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Section: Discussionmentioning

confidence: 99%

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Sánchez-González

Moreno

Aranda

et al. 2022

Biology

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“… 155 Metallothioneins, low molecular weight cysteine-rich proteins that can bind divalent metals such zinc or copper, determine the sequestration of the reactive oxygen species generated under stress conditions and can reduce hydroxyl radicals. 156 − 158 The release of the divalent zinc cation from its complex formed with metallothioneins or with cysteine residues of other proteins can lower reactive oxygenated species amounts, including those generated in viral infections. So, in this manner, zinc acquires indirect redox activity responsible for ensuring the endogenous antioxidant profile and anti-inflammatory activity.…”

Section: Zinc and Coppermentioning

confidence: 99%

“…Reactive oxygen species generation at low zinc levels were related to a diminished activity of Cu/Zn-specific superoxide dismutase, a key component of the first line antioxidant defense. , Zn inhibits nicotinamide adenine dinucleotide phosphate oxidase, a pro-oxidative enzyme and superoxide generator, and promotes metallothionein synthesis . Metallothioneins, low molecular weight cysteine-rich proteins that can bind divalent metals such zinc or copper, determine the sequestration of the reactive oxygen species generated under stress conditions and can reduce hydroxyl radicals. − The release of the divalent zinc cation from its complex formed with metallothioneins or with cysteine residues of other proteins can lower reactive oxygenated species amounts, including those generated in viral infections. So, in this manner, zinc acquires indirect redox activity responsible for ensuring the endogenous antioxidant profile and anti-inflammatory activity. , …”

Section: Zinc and Coppermentioning

confidence: 99%

Antioxidant, Anti-inflammatory, and Immunomodulatory Roles of Nonvitamin Antioxidants in Anti-SARS-CoV-2 Therapy

et al. 2022

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Viral pathologies encompass activation of pro-oxidative pathways and inflammatory burst. Alleviating overproduction of reactive oxygen species and cytokine storm in COVID-19 is essential to counteract the immunogenic damage in endothelium and alveolar membranes. Antioxidants alleviate oxidative stress, cytokine storm, hyperinflammation, and diminish the risk of organ failure. Direct antiviral roles imply: impact on viral spike protein, interference with the ACE2 receptor, inhibition of dipeptidyl peptidase 4, transmembrane protease serine 2 or furin, and impact on of helicase, papain-like protease, 3-chyomotrypsin like protease, and RNA-dependent RNA polymerase. Prooxidative environment favors conformational changes in the receptor binding domain, promoting the affinity of the spike protein for the host receptor. Viral pathologies imply a vicious cycle, oxidative stress promoting inflammatory responses, and vice versa. The same was noticed with respect to the relationship antioxidant impairment-viral replication. Timing, dosage, pro-oxidative activities, mutual influences, and interference with other antioxidants should be carefully regarded. Deficiency is linked to illness severity.

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“…В нормальных физиологических условиях Zn 2+ редокснеактивен, поэтому в процессах приема и передачи электронов он принимает участие опосредовано. Антиоксидантные свойства цинка представляют собой результат нескольких косвенных механизмов, а именно -ингибирование формирования ROS переходными металлами и сульфгидрильная стабилизация [65,66].…”

Section: антиоксидантные эффекты глицина и цинкаunclassified

“…Нарушение гомеостаза цинка, ведущее либо к истощению, либо к избытку цинка, вызывает серьезные повреждения нейронов [80]. Индуцированная цинком гибель клеток и изменения цинкового статуса мозга связаны с широким спектром заболеваний, включая многие нейродегенеративные расстройства, такие как болезнь Альцгеймера, и расстройства настроения, включая депрессию, болезнь Паркинсона, болезнь Хантингтона, боковой амиотрофический склероз и прионные болезни, а также расстройства аутического спектра [66,[81][82][83]…”

Section: биодоступность и поддержание уровня глицина и цинка в органи...unclassified

Molecular Mechanisms Defining Application of Glycine and Zinc Combinationin Correction of Stress and Anxiety Main Manifestations

Shishkova

Nartsissov

Titova

et al. 2022

Farm. farmakol. (Pâtigorsk)

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The aim of the work was to carry out a systematic analysis of the molecular mechanisms that determine the possibility of a combined use of amino acid glycine and zinc compounds for the treatment of patients with manifestations of stress and anxiety.Materials and methods. Information retrieval (Scopus, PubMed) and library (eLibrary) databases were used as research tools. In some cases, the ResearchGate application was applied for a semantic search. The analysis and generalization of references was carried out on the research topic, covering the period from 2000 to the present time.Results. It has been shown that amino acid glycine, along with gamma-aminobutyric acid (GABA), is a key neurotransmitter that regulates physiological inhibition processes in the central nervous system (CNS) by increasing transmembrane conductance in specific pentameric ligand-gated ion channels. The introduction of zinc ions can potentiate the opening of these receptors by increasing their affinity for glycine, resulting in an inhibitory processes increase in CNS neurons. The replenishment of the glycine and zinc combined deficiency is an important element in the correction of a post-stress dysfunction of the central nervous system. A balanced intake of zinc and glycine is essential for most people who experience daily effects of multiple stresses and anxiety. This combination is especially useful for the people experiencing a state of chronic psycho-emotional stress and maladaptation, including those who have a difficulty in falling asleep.Conclusion. A balanced maintenance of the zinc and glycine concentration in the body of a healthy person leads to the development of a stable anti-anxiety effect, which is accompanied by the normalization of the sleep-wake rhythm, which makes it possible to have a good rest without any loss of working efficiency after waking up.

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Clinical efficacy of zinc supplementation in improving antioxidant defense system: A comprehensive systematic review and time-response meta-analysis of controlled clinical trials

Cited by 12 publications

References 44 publications

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Antioxidant, Anti-inflammatory, and Immunomodulatory Roles of Nonvitamin Antioxidants in Anti-SARS-CoV-2 Therapy

Molecular Mechanisms Defining Application of Glycine and Zinc Combinationin Correction of Stress and Anxiety Main Manifestations

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