Clinical-Electroencephalographical and Polygraphical Research in Spasmophilic Hypomagnesian Syndromes

Popoviciu, L; Fagarasan, M.; Nicolaescu, I.; Farkas, Enikö; Oprisor, I.

doi:10.1159/000410583

Cited by 1 publication

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“…sleep organization disorders with long waking periods, frequent changes of sleep stages, predominance of light SWS with decrease of dura tion of deep SWS and occurrence of polyspikes have been seen in humans with spasmophilic hypomagnesian syn dromes [8], Since magnesium administration shows a fast regulatory effect on the sleep-wakefulness cycle, we can consider that, in some pathological cases, magnesium administration could provide a therapeutic benefit on sleep organization.…”

Section: Discussionmentioning

confidence: 99%

“…Spasmo philic syndromes are also often accompanied by biochem ical changes of Mg2+ metabolism [8], Because of its possi ble therapeutic benefit, the administration of Mg2+ has been recommended in cardiovascular diseases and in psy chiatric disorders [1.6], Magnesium deficiency is characterized by different pathological manifestations: neuromuscular (weakness, tremors, muscle fasciculations), cardiac (arrhythmia, an gina. infarction, hypertension), central (depression, agita tion, psychosis, seizures) and metabolic (hypokalemia, hypocalcemia) [1], Electroencephalography (EEG) is one of the most valuable methods to investigate the clinical and behavioral effects of Mg2+ metabolic disorders.…”

Section: Introductionmentioning

confidence: 99%

“…For example, clinical EEG abnormalities e.g. predominance of light sleep with long waking periods and occurrence of polyspikes were characterized in the spasmophilic hypomagnesian syndromes in man [8].…”

Section: Introductionmentioning

confidence: 99%

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Effects of a Magnesium Deficient Diet on Sleep Organization in Rats

Depoortere¹,

Françon²,

Llopis

1993

Neuropsychobiology

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The influence of magnesium, one of the most important cations in the vertebrate body, on the sleep-wakefulness cycle and ECoG patterns in chronically implanted rats recorded during the light period over a 6-hour period was investigated. Two groups of rats were studied. Group 1 (6 rats): after a control period of 2 weeks, the rats were maintained for 9 weeks on a Mg²⁺-deficient diet. Group 2 (5 rats): after a control period of 2 weeks, the rats were maintained for 7 weeks on a Mg²⁺-deficient diet followed by 4 weeks on a normal diet (recovery period: weeks 8–11). Mg²⁺-deficient diet for 9 weeks induced sleep and ECoG time-dependent alterations. After 6–7 weeks on a Mg²⁺-defi-cient diet (n = 11) sleep analysis showed a significant increase of wakefulness (+50%) at the expense of slow wave sleep (–24%) but paradoxical sleep was not significantly modified. After 9 weeks of a Mg²⁺ deficient diet, sleep was desorganized: light sleep and polyspikes occurred indicating an increase in neuronal excitability. When Mg²⁺ was reintroduced in food and water, sleep organization and ECoG recordings were restored to their original patterns. Our findings which are in line with previous clinical and pharmacological observations provide conclusive arguments for the neuroprotective effect of magnesium ions in neurologic disorders and epileptiform activity. Mg²⁺ deficiency induces ECoG alterations in the rat which bear some similarities with those seen in neurogenic spasmophilic syndromes in man.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%