Clinical electrophysiology of axonal polyneuropathies

McCorquodale, Donald; Smith, A. Gordon

doi:10.1016/b978-0-444-64142-7.00051-5

Cited by 10 publications

(9 citation statements)

References 217 publications

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“…Diagnosis of demyelination or dysmyelination carries important therapeutic and prognostic implications. Electromyography and nerve conduction studies are routinely used to assess peripheral nerves lesions 3,4 . However, they are not characteristic of a specific disease or able to give a definitive diagnosis, and have some limitations that may lead to misdiagnosis.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Imaging as a Biomarker in Rodent Peripheral Nerve Injury Models Reveals an Age-Related Impairment of Nerve Regeneration

Giorgetti

Obrecht

Ronco

et al. 2019

Sci Rep

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Assessment of myelin integrity in peripheral nerve injuries and pathologies has largely been limited to post-mortem analysis owing to the difficulty in obtaining biopsies without affecting nerve function. This is further encumbered by the small size of the tissue and its location. Therefore, the development of robust, non-invasive methods is highly attractive. In this study, we used magnetic resonance imaging (MRI) techniques, including magnetization transfer ratio (MTR), to longitudinally and non-invasively characterize both the sciatic nerve crush and lysolecithin (LCP) demyelination models of peripheral nerve injury in rodents. Electrophysiological, gene expression and histological assessments complemented the extensive MRI analyses in young and aged animals. In the nerve crush model, MTR analysis indicated a slower recovery in regions distal to the site of injury in aged animals, as well as incomplete recovery at six weeks post-crush when analyzing across the entire nerve surface. Similar regional impairments were also found in the LCP demyelination model. This research underlines the power of MTR for the study of peripheral nerve injury in small tissues such as the sciatic nerve of rodents and contributes new knowledge to the effect of aging on recovery after injury. A particular advantage of the approach is the translational potential to human neuropathies.

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Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Imaging as a Biomarker in Rodent Peripheral Nerve Injury Models Reveals an Age-Related Impairment of Nerve Regeneration

Giorgetti

Obrecht

Ronco

et al. 2019

Sci Rep

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“…The proximal lumbosacral nerve roots, however, have never been covered. Pathologically, the axonal injury can progress from the distal segment to the proximal segment in a "dying-back" pattern (23). In this study, the disease duration of patients with axonal PNPs was relatively long (the median disease duration was 11.50 months), and consequently, the proximal nerve roots were likely to be involved, which might account for the decrease in FA value.…”

Section: Discussionmentioning

confidence: 73%

“…Research indicates that demyelinating PNPs, especially CIDP, exhibit nerve enlargement in a proximally predominating pattern, whereas in axonal PNPs, nerve enlargement is prone to occur in distal segments, if any. This differential distribution of nerve enlargement actually reflects the length-dependent nature of axonal PNPs and the preferential and predominant involvement of proximal nerve roots and segments in acquired demyelinating PNPs, in particular CIDP (7,(22)(23)(24). Based on this observation, this study used MRI to visualize the lumbosacral nerve roots where ultrasound was not accessible, and quantified the mean size among 3 groups.…”

Section: Discussionmentioning

confidence: 99%

MR neurography of lumbosacral nerve roots for differentiating chronic inflammatory demyelinating polyneuropathy from acquired axonal polyneuropathies: a cross-sectional study

Wu¹,

Wang²,

Yang³

et al. 2022

Quant Imaging Med Surg

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Background: Magnetic resonance (MR) neurography is an imaging technique focused on the peripheral nerves. Its role in the diagnosis and differential diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) has yet to be investigated. This study explored the value of MR neurography in identifying CIDP and differentiating it from acquired axonal polyneuropathies. Methods:In this study, 20 patients with CIDP, 10 patients with acquired axonal polyneuropathies, and 20 healthy controls were prospectively enrolled. Three-dimensional T2-weighted image fat-suppressed and diffusion tensor imaging sequences of the lumbosacral plexus were completed in all participants. The cross-sectional area (CSA) and diffusion parameters, including the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of the L3 to S1 nerve roots, were measured and compared across the 3 groups using Kruskal-Wallis 1-way analysis of variance. Receiver operating characteristic (ROC) curves were plotted to determine the value of CSA and diffusion parameters in the diagnosis and differential diagnosis of CIDP.Results: CSA and ADC increased in CIDP patients but didn't differ between patients with axonal polyneuropathies and healthy controls (CAS: 45.35±23.889, 22.25±3.878, 22.81±4.079 mm 2 , ADC:(1.64±0.269)×10 -3 mm 2 /s, (1.37±0.204)×10 -3 mm 2 /s and (1.39±0.156)×10 -3 mm 2 /s, in CIDP, axonal polyneuropathies and healthy controls, respectively, both P<0.001). Compared with healthy controls, FA reduced in patients with CIDP and axonal polyneuropathies but no difference was observed in the two groups (FA: 0.24±0.053, 0.27±0.014 and 0.32±0.045, in CIDP, axonal polyneuropathies and healthy controls, respectively, P<0.001). To identify CIDP, ROC analysis showed that FA had better efficiency with cut-off value of 0.278 and sensitivity and specificity of 85% and 90% respectively. To differentiate CIDP from axonal polyneuropathies, CSA had better diagnostic accuracy with cut-off value of 29.46 mm 2 and sensitivity and specificity of 75% and 100% respectively. Conclusion:CSA and ADC values of lumbosacral nerve roots can help to identify patients with CIDP and further distinguish them from patients with axonal polyneuropathies. FA decreased in both types of polyneuropathies and may thus have limited value in the discrimination of the 2 types of neuropathies.

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“…Dies umfasst auch die mitochondriale DNA, sodass es auch zu einer mitochondrialen Funktionsstörung kommt 1 8 10 13 15 , 16–21]. Es sind insbesondere die sensiblen Spinalganglien betroffen, wo sich platinhaltige Substanzen vorwiegend anreichern, sodass insbesondere auch von einer Neuronopathie ausgegangen wird 1 2 4 6 8 9 10 11 13 14 15 16 17 20 21 22 . Passend dazu ist eine eher diffuse Verteilung der Gefühlsstörungen beschrieben 9 .…”

Section: Chemotherapeutikaunclassified

“…Es sind insbesondere die sensiblen Spinalganglien betroffen, wo sich platinhaltige Substanzen vorwiegend anreichern, sodass insbesondere auch von einer Neuronopathie ausgegangen wird 1 2 4 6 8 9 10 11 13 14 15 16 17 20 21 22 . Passend dazu ist eine eher diffuse Verteilung der Gefühlsstörungen beschrieben 9 . Auch eine Hinterstrangschädigung, die sich klinisch durch ein Lhermitte-Zeichen bemerkbar machen kann, kann vorkommen 8 14 19 .…”

Section: Chemotherapeutikaunclassified

Medikamentös-induzierte Polyneuropathien durch Chemotherapeutika und Antiinfektiva

Achenbach¹,

Block²,

Dafotakis³

2022

Klinische Neurophysiologie

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Polyneuropathien können durch zahlreiche Wirkstoffe hervorgerufen oder aggraviert werden. Insbesondere die Chemotherapeutika-induzierte Polyneuropathie (CIPN) ist im Alltag von hoher Relevanz. Jedoch kann auch der Einsatz von Antiinfektiva zu neuropathischen Beschwerden führen. Im Folgenden soll ein Überblick über die wichtigsten mit Polyneuropathien assoziierten Wirkstoffe der Substanzklassen sowie die klinischen Charakteristika gegeben werden.

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Clinical electrophysiology of axonal polyneuropathies

Cited by 10 publications

References 217 publications

Magnetic Resonance Imaging as a Biomarker in Rodent Peripheral Nerve Injury Models Reveals an Age-Related Impairment of Nerve Regeneration

Magnetic Resonance Imaging as a Biomarker in Rodent Peripheral Nerve Injury Models Reveals an Age-Related Impairment of Nerve Regeneration

MR neurography of lumbosacral nerve roots for differentiating chronic inflammatory demyelinating polyneuropathy from acquired axonal polyneuropathies: a cross-sectional study

Medikamentös-induzierte Polyneuropathien durch Chemotherapeutika und Antiinfektiva

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