Clinical, Endoscopic, Pathological and Serological Findings of Helicobacter pylori Infection in Saudi Patients with Upper Gastrointestinal Diseases

Abo-Shadi, Maha A.; Elshazly, Tarek A.; S., Al-Johani, Mariam

doi:10.9734/bjmmr/2013/2650

Cited by 5 publications

(5 citation statements)

References 55 publications

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“…This study showed that H. pylori infection was diagnosed in 72.8% of the studied patients. prevalence of infection in our study is comparable to that found in a Saudi study conducted by Abo-Shadi et al [1], where H. pylori infection was detected in 64.7% of the gastric biopsy specimens from patients with upper gastrointestinal diseases. The prevalence found in our study lies within the wide range of H. pylori infection (50-80%) reported in Saudi Arabia [5].…”

Section: Discussionsupporting

confidence: 90%

Association of Helicobacter pylori cagA Gene with Gastric Cancer and Peptic Ulcer in Saudi Patients

Saber

Ghonaim

Yousef

et al. 2015

Journal of Microbiology and Biotechnology

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This study was conducted to assess the relationship between occurrence of gastric cancer and peptic ulcer, and the presence of H. pylori cagA gene and anti-CagA IgG, and to estimate the value of these antibodies in detecting infection by cagA gene-positive H. pylori strains in Saudi patients. The study included 180 patients who were subjected to upper gastrointestinal endoscopy in Taif province and Western region of Saudi Arabia (60 gastric cancer, 60 peptic ulcer, and 60 with non-ulcer dyspepsia). Gastric biopsy specimens were obtained and tested for H. pylori infection by rapid urease test and culture. PCR was performed on the isolated strains and biopsy specimens for detection of the cagA gene. Blood samples were collected and tested for CagA IgG by ELISA. H. pylori infection was detected among 72.8% of patients. The cagA gene and anti-CagA IgG were found in 63.4% and 61.8% of H. pylori-infected patients, respectively. They were significantly (p < 0.01) higher in patients with gastric cancer and peptic ulcer compared with those with non-ulcer dyspepsia. Detection of the CagA IgG was 91.6% sensitive, 89.6% specific, and 90.8% accurate compared with detection of the cagA gene. Its positive and negative predictive values were 93.8% and 86%, respectively. The study showed a significant association between the presence of the cagA gene and gastric cancer and peptic ulcer disease, and between anti-CagA IgG and the cagA gene in Saudi patients. However, a further larger study is required to confirm this finding.

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Section: Discussionsupporting

confidence: 90%

Association of Helicobacter pylori cagA Gene with Gastric Cancer and Peptic Ulcer in Saudi Patients

Saber

Ghonaim

Yousef

et al. 2015

Journal of Microbiology and Biotechnology

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“…In a study from Mumbai, age related prevalence of Helicobacter pylori showed similar results as ours with maximum prevalence of 58% in the age group of 30-39 years 36 . Our study revealed that there was not a correlation between sex and H. pylori positivity (P=0.982, this result is in agreement with study performed by (AboShadi et al) 37 , but disagree with other studies (AAmeri and Alkadasi) 29 .…”

Section: Discussionsupporting

confidence: 78%

Prevalence of Helicobacter Pylori Among Asymptomatic Populations in Sana'a, Yemen

Alyahawi

Al-kaf

Alzaghrori

2018

UJPR

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Helicobacter pylori consider the most important cause of chronic gastritis and also the most important etiological factor responsible for the duodenal and gastric ulcer and have an important role in the pathogenesis of gastric cancer. The aim of the present study to know the prevalence of H. pylori among the khat chewing adults in compared to non-khat chewing among asymptomatic populations. A total of 82 healthy subjects were screened to find out the prevalence of Helicobacter pylori using stool antigen card test during the period started in 16 April 2018 and ending in 8 May 2018 in Sana'a, Yemen. Predesigned questionnaire was used to collect information such as age, sex, education status, khat chewing, smoking, tobacco chewing, occupation, and tests results all above data were recorded for each subject. Patients who had taken proton pump inhibitors or antibiotic for a month prior to study were excluded. Out of these 82 asymptomatic individuals, 36 were found positive for Helicobacter pylori by the test, giving a prevalence of 43.9 %. A prevalence of 26.9 % (62.9 % of khat chewing) was khat chewing individuals and it had statistically significant difference. A prevalence of 14.6 % was seen among cigarette smoking participants. The present study revealed substantial prevalence of Helicobacter pylori in khat chewing healthy subjects. A higher prevalence of Helicobacter pylori seen in these subjects may be contributed to khat chewing. Identification of khat chewing populations, who do not show symptoms of Helicobacter pylori infection, is essential for controlling the infection and it still remains a challenge for the clinicians.

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“…Another study in the same country done by Abo-shadi et al [16] showed that H. Pylori infection was detected in 64.7% of the gastric biopsy specimens from patients with upper gastrointestinal diseases.…”

Section: Discussionmentioning

confidence: 87%

Association Between Proteinuria and Active Helicobacter Pylori Infection in Non-Diabetic Patients

Balat¹,

Zanaty²,

Elantouny³

et al. 2019

Zagazig University Medical Journal

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Background: The incidence Helicobacter pylori infection and its possible relationship to different diseases are a focus of attention nowadays. Therefore, the aim of this study was to examine the association between proteinuria and active Helicobacter pylori infection in middle age nondiabetic patients. Material and Methods: A Case-control study was conducted on118 subjects and included 59 patients who suffered from H. pylori infection from October 2017 to April 2018. 59 patients were negative H. pylori infection included and served as a control group. Demographic and clinical data were collected. Results: The infected H. Pylori group showed a significant higher ACR compared to the control group. In addition, infected H. Pylori group showed a significant lower hemoglobin and albumin compared to the control group. Conclusion: Patients having H. Pylori infection show a significant elevation in the urinary albumin/creatinine ratio and a significant anemia suggesting a role of H. Pylori infection in the pathogenesis of proteinuria and anemia.

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Clinical, Endoscopic, Pathological and Serological Findings of Helicobacter pylori Infection in Saudi Patients with Upper Gastrointestinal Diseases

Cited by 5 publications

References 55 publications

Association of Helicobacter pylori cagA Gene with Gastric Cancer and Peptic Ulcer in Saudi Patients

Association of Helicobacter pylori cagA Gene with Gastric Cancer and Peptic Ulcer in Saudi Patients

Prevalence of Helicobacter Pylori Among Asymptomatic Populations in Sana'a, Yemen

Association Between Proteinuria and Active Helicobacter Pylori Infection in Non-Diabetic Patients

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