Clinical, epidemiological and laboratory features of Salmonellosis in children at the present stage

Климовицкая, Е. Г.; Eshmolov, S. N.; Ситников, И. Г.

doi:10.22627/2072-8107-2019-18-4-49-52

Cited by 3 publications

(2 citation statements)

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“…В 34% случаев была установлена этиологическая структура ГК, превалировали сальмонеллез (36%) и шигеллез (36%). Согласно данным литературы, среди бактериальных возбудителей ОКИ с гемоколитом или без доминирует сальмонелла [1][2][3][4][5]7]. В нашем исследовании мы получили одинаковую долю больных с гемоколитом с сальмонеллезом и шигеллезом, однако мы счита- Campylobacter ем, что такое большое количество шигеллеза получилось из-за вспышки 2019 г. в детских учреждениях Москвы [9].…”

Section: заключениеunclassified

“…), протеозы и гельминтозы (амебиаз, балантидиаз, шистосомоз и др. ), а также антибиотико-ассоциированная диарея (ААД) [1][2][3][4][5][6][7][8][9]. Гемоколит неинфекционной природы наиболее часто возникает при воспалительных заболеваниях кишечника (язвенном колите, Болезни Крона), при пищевой аллергии на белки коровьего молока, при лактазной недостаточности, при врожденных заболеваниях кишечника (болезни Гиршпрунга, дивертикуле Меккеля), при инвагинации кишечника, анальных трещинах, полипах и др.…”

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Hemorrhagic colitis syndrome in children: the etiological structure in the infectious diseases clinic

et al. 2021

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The range of differential diagnostic search in the development of hemorrhagic colitis (hemocolitis) is wide enough and includes infectious and non-infectious factors. Purpose: clinical, laboratory and etiological analysis of bacterial diarrhea occurring with hemorrhagic colitis in the infectious diseases department.Materials and methods: a retrospective study of 141 case histories of those hospitalized in the infectious diseases department of the2 Children's City Clinical Hospital No. 9 named after G.N. Speransky of Moscow in 2019—2021 patients with clinical picture of hemocolitis. Hemocolitis was determined on the basis of macroscopic and microscopic signs (in scatology — mucus, leukocytes, erythrocytes) signs. All patients underwent routine laboratory examinations. The etiology was verified using modern methods of laboratory diagnostics (bacteriological analysis of feces, Latex test, ICA, ELISA, PCR, IHR).Results. There were 137 patients with infectious hemocolitis. Inflammatory bowel disease was diagnosed in 3 children, anus fissure — in 1 child. Young children under 3 years of age prevailed (77%). The etiology of infectious hemocolitis was deciphered in 47 patients (34%). Salmonellosis (36%) and shigellosis (36%) prevailed. Campylobacteriosis, clostridiosis-dificile and klebsiellosis accounted for 11%, 9% and 6% of cases, respectively. Yersiniosis was detected in 1 child at the age of 5 months. The severe form was found in 5.8% of cases, in most cases with shigellosis. Symptoms of intoxication and febrile fever were expressed in all patients, vomiting — in 28.5%, abdominal pain — in 94%, mesenteric adenitis on ultrasound — in 15%, diarrhea with a frequency of more than 5 times a day — in 84%, dehydration — in 64%, intercurrent diseases (ARVI, pneumonia) — in 41.3% of cases. Inflammatory changes in infectious hemocolitis were manifested by an increase in C-reactive protein in 71% (23.91 ± 24.17 mg/l), leukocytosis — in 69% (11.58 ± 3.52 х103 / μl), thrombocytosis — in 26%, an increase in the relative number of stab neutrophils in the general blood test in 78% of cases (10.95 ± 0.4%).Conclusions. Differential diagnostic search in the development of hemocolitis should include modern diagnostic methods, if necessary, additional instrumental studies and specialist consultations to exclude inflammatory bowel diseases.

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Hemorrhagic colitis syndrome in children: the etiological structure in the infectious diseases clinic

et al. 2021

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Salmonellosis osteomyelitis of the pelvic bones in adolescent: a case report

Andreev,

Baranov,

Vecherkin

et al. 2024

Russian Journal of Pediatric Surgery, Anesthesia and Intensive

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Salmonellosis osteomyelitis is a rare form of extraintestinal salmonellosis in children that occurs against the background of sepsis. This article presents observation of salmonellosis osteomyelitis in a previously healthy 17-year-old patient. The patient experienced pain in the right lower limb with restriction of its mobility. Magnetic resonance imaging revealed bone-destructive changes in the lumbosacral spine. Thrombocytopenia progressed to 60×109/l. In the oncohematologic domain, secondary character of thrombocytopenia was established, and iliac–lumbar muscle abscesses were found. The child was transferred to a surgical hospital, and sepsis, osteomyelitis of the right lateral mass of the sacrum, right-sided sacroiliitis, abscess of the right iliopsoas muscle, bilateral polysegmental pneumonia, and bilateral pleuritic were diagnosed. Surgical opening and drainage of the abscess of the lumbosacral muscle was performed. The study of abscess secretion detected Salmonella gr. B Chester, a resistance gene to penicillins, cephalosporins, and carbapenems. Therapy with off-label ciprofloxacin at 400 mg with pronounced positive dynamics. Cases of treatment of patients with atypical forms of salmonellosis show the need for further accumulation of experience, modification of treatment protocols, and verification of pathogens at an early stage for greater therapy effectiveness.

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Main Manifestations of the Epidemic Process of Acute Intestinal Infections in the Far Eastern Federal District in 2022

Trotsenko,

Sapega,

Butakova

et al. 2024

PH&LE

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Background: Diarrheal diseases consistently occupy one of the leading positions in the structure of infections, especially in children under the age of 5 years. A decrease in the incidence of bacterial intestinal infections and an increase in viral ones have been observed recently with an uneven territorial distribution of registered cases. Objective: To characterize the main manifestations of the epidemic process of acute intestinal infections in the Far Eastern Federal District of the Russian Federation in 2022. Materials and methods: Based on official statistics, we analyzed the incidence of acute intestinal infections by age groups, types, and administrative territories of the federal district; we also examined the outbreaks of these infections registered in 2022. Results: We established that the incidence rates of almost all leading acute intestinal infections (except for shigellosis) in the Far Eastern Federal District were higher than the Russian averages. Viral infections prevailed in the diarrhea cases with identified pathogens. Children under 6 years of age were found to be the most affected population while the highest incidence was observed in the age group of 1–2 years. We noted differences between the areas of the District and established higher disease rates in 4 of its 11 regions. Oral and direct contact routes of transmission generally prevailed, especially in collectives, leading to outbreaks. Conclusion: In general, the manifestations of the epidemic process of acute intestinal infections noted in 2022 indicate the persistence of potential epidemiologic risks of both sporadic cases and outbreaks on the territories of the Far East.

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Clinical, epidemiological and laboratory features of Salmonellosis in children at the present stage

Cited by 3 publications

References 1 publication

Hemorrhagic colitis syndrome in children: the etiological structure in the infectious diseases clinic

Hemorrhagic colitis syndrome in children: the etiological structure in the infectious diseases clinic

Salmonellosis osteomyelitis of the pelvic bones in adolescent: a case report

Main Manifestations of the Epidemic Process of Acute Intestinal Infections in the Far Eastern Federal District in 2022

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