Clinical epidemiology of Guillain–Barré syndrome in adults in Sweden 1996–97: a prospective study

Cheng, Qi; Jiang, Guo-Xin; Press, Rayomand; Andersson, Marine L.; Ekstedt, Bertil; Vrethem, Magnus; Liedholm, L. J.; Lindsten, Hans; Brattström, Lars; Fredrikson, Sten; Link, H.; Pedro‐Cuesta, Jesús de

doi:10.1046/j.1468-1331.2000.00128.x

Cited by 43 publications

(39 citation statements)

References 36 publications

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“…Campylobacter jejuni , a gastrointestinal infection, is the most commonly identified antecedent infection among GBS cases [5]; however, recent studies have also found an increased risk of GBS in the period immediately following influenza-like illness [10,26,27]. Our results show a higher proportion of patients treated with intravenous immune globulin (74%) compared with older studies (30–40%) [3], reflecting the shift in treatment preference following randomized control results which show that IgIV has similar efficacy to plasma exchange and is more convenient to administer [5]. The clinical course of GBS in our study was in agreement with that from other case series [5].…”

Section: Discussioncontrasting

confidence: 45%

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Guillain-Barré Syndrome Incidence in a Large United States Cohort (2000–2009)

Shui

Rett²,

Weintraub³

et al. 2012

Neuroepidemiology

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Background/Aim: We describe the incidence of Guillain-Barré syndrome (GBS) in a large United States cohort. Methods: Between 2000 and 2009, we identified visits with an ICD-9 code for GBS (357.0) from all persons with continuous enrollment for at least 1 year. The primary case definition was restricted to emergency department and inpatient visits. We calculated age-standardized rates and used multivariate Poisson regression to assess variation in rates by sex, age, season and year of diagnosis. We tabulated descriptive characteristics and the positive predictive value (PPV) for a subset of the visits with available medical record review. Results: 1,619 visits with the GBS ICD-9 code were identified from 50,290,898 person-years of observation. After considering the PPV (55%) for record-reviewed visits, the age-standardized incidence rate was approximately 1.72/100,000 person-years. The rate was 40% higher for males and increased by 50% for every 10-year increase in age. The rate was 15% higher in winter and spring compared with summer. Rates were higher in more recent years. Conclusions: GBS rates are higher in males and increase considerably with age. The potential reasons for differences in rates by season and the increased rates in more recent years should be further investigated.

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Section: Discussioncontrasting

confidence: 45%

“…A comprehensive review estimated GBS incidence rates in North America and Europe to be between 1–2 per 100,000 person-years [2]. The rate increases with age and male sex [2,3,4]. Strong seasonal associations or clear secular trends in GBS rates have not been documented [2,5].…”

Section: Introductionmentioning

confidence: 99%

Guillain-Barré Syndrome Incidence in a Large United States Cohort (2000–2009)

Shui

Rett²,

Weintraub³

et al. 2012

Neuroepidemiology

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“…Mortality rate ranges from 2-13% in different studies. Dana I, et al 22 study shows 5%, Italian GBS study group shows (up to 12%), Cherg Q, et al (2000) 18 shows 8%, Nicholas, et al (1998) 20 shows 4%, Italian study (1988-93) 9%, South England (1993-94) shows 9%,Voston MGH (1962-81) shows 2%, Brazil study (2003) shows 10% mortality among all GBS case. In our study mortality rate was 7% which is comparable to other studies.…”

Section: Discussionmentioning

confidence: 95%

Guillain Barre Syndrome: Major Cause of Acute Flaccid Paralysis in Children and Adolescents of Nepal

Sharma

Singh

Shah

2011

J. Nepal Paedtr. Soc.

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Introduction. Guillain Barre Syndrome (GBS) is a post infectious polyneuropathy involving mainly motor but sometimes sensory and autonomic nerves. It is an acquired disease of the peripheral nerves that is characterized by rapidly progressing paralysis, areflexia and albumino-cytological dissociation in CSF. Methodology: Prospective, descriptive, observational, hospital based study was carried out to find out the clinico-epidemiological features of GBS including existing treatment modalities and its outcome. All cases fulfilled the criteria for AFP (Acute flaccid Paralysis) surveillance was included. Cases were reviewed for full medical history and examinations. To confirm the diagnosis, necessary investigations were carried out and combined with clinical symptoms. Results: Thirty patients were included in the study during study period. Among them 90% were diagnosed as GBS, 7.4% patients of GBS were associated with hypokalemic paralysis, 7.4% diagnosed as transverse myelitis and 3.7% diagnosed as idiopathic neuropathy. Different types of GBS were classified as AIDP (Acute inflammatory demyelinating polyneuropathy) 62.96%, AMAN (Acute motor axonal neuropathy) -25.52%, AMASAN (Acute motor and sensory axonal neuropathy) -3.3% and MFS (Miller fisher's syndrome) -6.6% according to NCV result. Male female ratio is 1.7:1.0. There was 14.8% patients had relapse within 5 year. Associated diseases were URTI, pneumonia, sore throat and diarrhea. Facial Nerve palsy was commonest cranial nerve involvement.Sixty percentage of patients presented with sensory symptoms. There was transient bowel and bladder involvement in 20% of the cases. 69.2% patients became bed ridden at the nadir. There was albumin-cytological dissociation in 80% case. Majority of patients improved with supportive treatment alone, 19.5% patient required ventilator support among them 40% died. 7.4% of cases expired during treatment. Half of the patients fully recovered within 3 months. Conclusion: GBS is the commonest cause of AFP, AIDP being commonest subtype in our setting. We have to improve our existing treatment facilities and extend to different centers to detect and treat GBS. Most of the patients improve with supportive treatment alone. Ventilator support indicates grave prognosis.

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“…This is of interest because GBS is a disorder that is reportedly more common in males than females [48]. Furthermore, GBS is thought to be an autoimmune disorder, and presumably patients develop GBS because they have T cell or antibody reactivity to an antigen important in GBS.…”

Section: Discussionmentioning

confidence: 99%

Effect of gender on T-cell proliferative responses to myelin proteolipid protein antigens in patients with multiple sclerosis and controls

Greer

Csurhes

Pender

et al. 2004

Journal of Autoimmunity

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Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system. Gender influences both susceptibility to MS, with the disease being more common in women, and the clinical course of disease, with an increased proportion of males developing the primary progressive form of the disease. The basis for these differences may include genetic and immunological factors, and the immunological differences between men and women may be influenced by the effects of the sex hormones. Over several years we have collected blood from MS patients and controls, and measured T-cell responses to myelin proteolipid protein (PLP) and myelin basic protein (MBP) and have shown increased responses to PLP in MS patients compared to healthy controls and patients with other neurological diseases. In the present study we analyzed data from over 500 individuals, to determine whether there are differences between males and females in their responses to PLP and MBP. We found that there was higher frequency of increased T-cell reactivity to immunodominant PLP peptides in women than in men, particularly in non-MS individuals. We suggest that this may be relevant to the higher prevalence of MS in women.

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Clinical epidemiology of Guillain–Barré syndrome in adults in Sweden 1996–97: a prospective study

Cited by 43 publications

References 36 publications

Guillain-Barré Syndrome Incidence in a Large United States Cohort (2000–2009)

Guillain-Barré Syndrome Incidence in a Large United States Cohort (2000–2009)

Guillain Barre Syndrome: Major Cause of Acute Flaccid Paralysis in Children and Adolescents of Nepal

Effect of gender on T-cell proliferative responses to myelin proteolipid protein antigens in patients with multiple sclerosis and controls

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