Clinical evaluation and treatment of phaeochromocytoma

Davison, Andrew S.; Jones, Danielle M; Ruthven, Stuart; Helliwell, T. R.; Shore, Susannah

doi:10.1177/0004563217739931

Cited by 39 publications

(33 citation statements)

References 131 publications

(200 reference statements)

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“…Abdominal ultrasound in the search of pheochromocytoma is no longer recommended [1] [2] [3] [4] and [16]. However, it had allowed the detection of 10 pheochromocytoma in our patients with large tumour and probably delayed diagnosis.…”

Section: Discussionmentioning

confidence: 98%

“…In case of persistence of tachycardia, beta-blockers should be introduced. But it is necessary to have current and effective alpha blocking treatment [2] [4]. Thirteen patients underwent surgical procedure.…”

Section: Discussionmentioning

confidence: 99%

“…This choice seems more judicious since the tumours in our patients having tumours of big size. Indeed, the laparoscopic surgery in the pheochromocytomais indicated for small tumours, lower than 4 cm in diameter [4]. For the management of the malignant pheochromocytoma, the surgical resection of the primary tumour could decrease the risk of metastases and improve total survival in spite of advanced disease.…”

Section: Discussionmentioning

confidence: 99%

“…Pheochromocytomas are usually benign tumours; its malignity as for all neuroendocrine tumours is defined by existence of distant metastases [2]. Pheochromocytomas are under diagnosed in occident where 0.05% to 0.1% are discovered at the time of autopsies [3] [4]. In Africa, few series had been reported [5] [6] [7].…”

Section: Introductionmentioning

confidence: 99%

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Management of Pheochromocytoma in Dakar: Diagnostic and Therapeutic Advances throughout 16 Cases

Leye¹,

Ndiaye²,

Leye³

et al. 2018

OJEMD

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Introduction: Management of pheochromocytoma faces different challenges leading to misdiagnosis and therapeutic delay in developing countries. The aim of our study was to evaluate the diagnostic and therapeutic features as well as the evolution of our management strategies in hospital setting in recent years in Dakar. Patients and Method: We carried out a retrospective study over 12 years (January 2005 to June 2017), in 4 hospitals in Dakar. We only included patients with established diagnosis of pheochromocytoma upon clinical, biological, radiological and histological arguments. Results: During this period, 16 observations have been collected and were all about female patients. The mean age at the time of diagnosis was 36.81 years. The clinical signs were dominated by hypertension found for 14 patients. At biological examination, hypersecretion catecholamine was found in 13 patients, high urinary metanephrines in 7 patients, high plasmatic metanephrines in 2 patients and raised urinary Vanyl Mandelic Acid (VMA) in 4 patients. Dosage of chromogranin A showed high level for one patient. Abdominal CT scan allowed making the adrenal origin of tumors precise. One patient presented bilateral pheochromocytoma. Before being treated surgically, all patients had had medical preparation. The surgical treatment by median laparotomy consisted of an enucleation of the tumor in 2 patients, and adrenal resection in 11patients.The evolution after surgery was favorable in 12 patients out of 13. One patient died 2 days after surgery by hemodynamic instability. In 2 patients who presented metastases, multidrug therapy with cyclophosphamide, vincristine and dacarbazine was decided after a multidisciplinary meeting, but they died before treatment. Conclusion: Management of pheochromocytomas in developing countries is obviously improving, but the mortality rate remains high. Early diagnosis and perioperative care are to be targeted for better outcome and prognosis of this rare tumor in our areas.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Management of Pheochromocytoma in Dakar: Diagnostic and Therapeutic Advances throughout 16 Cases

Leye¹,

Ndiaye²,

Leye³

et al. 2018

OJEMD

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“…As reported in our case, abdominal ultrasound with the identification of adrenal mass is one of the first steps for the pheochromocytoma diagnosis. Ultrasound is usually followed by CT or magnetic resonance imaging (MRI) to confirm the lesion and plan the surgery (23). Nevertheless, identification of adrenal mass in pregnancy can be difficult by ultrasounds due to the enlargement of uterus and other first level evaluation diagnostic approaches should be considered like MRI or CT (12)(13)(14).…”

Section: Discussionmentioning

confidence: 99%

Late diagnosis of pheochromocytoma in pregnancy with poor fetal outcome

et al. 2021

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Pheochromocytomas are rare tumors producing catecholamines that could be a cause of secondary hypertension. On that basis, pheochromocytoma can occur as an extremely rare cause of hypertension in pregnancy and if diagnosed late can lead to adverse maternal-fetal outcome. In this case report we describe a case of pheochromocytoma affected pregnancy with poor fetal outcome. A 27-year-old pregnant woman was admitted for severe pre-eclampsia due to pre-gestational hypertension that was diagnosed during the first trimester. Due to high and uncontrolled maternal blood pressure and the worsened maternal-fetal condition after the admission induction of fetal lung maturity and emergency cesarean section were performed, but with poor fetal outcome. Later, an adrenal gland mass was identified using abdominal ultrasound and confirmed by computed tomography. After surgical adrenalectomy blood pressure of the patient was normalized. Pheochromocytoma should be considered as a possible cause of hypertensive disorder during pregnancy, particularly in cases of severe and unresponsive hypertension in order to provide for timely and appropriate treatment.

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Masqueraders of Anaphylaxis

Upton

2020

Anaphylaxis

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Clinical evaluation and treatment of phaeochromocytoma

Cited by 39 publications

References 131 publications

Management of Pheochromocytoma in Dakar: Diagnostic and Therapeutic Advances throughout 16 Cases

Management of Pheochromocytoma in Dakar: Diagnostic and Therapeutic Advances throughout 16 Cases

Late diagnosis of pheochromocytoma in pregnancy with poor fetal outcome

Masqueraders of Anaphylaxis

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