Clinical evaluation of [123I]FP-CIT SPECT scans on the novel brain-dedicated InSPira HD SPECT system: a head-to-head comparison

Abstract

The InSPira HD system, a novel brain-dedicated SPECT scanner, allows for imaging with a high spatial resolution. Here, we tested whether this scanner can be used to image the dopamine transporter adequately. Therefore, striatal phantom and patient data acquired on the InSPira were compared head-to-head with the well-validated brain-dedicated NeuroFocus system. A striatal phantom filled with [123I] and 14 subjects (after [123I]FP-CIT injection) were scanned on both systems. [123I]FP-CIT SPECT scans were visually assessed. Striatal binding ratios were calculated automatically using the software package BRASS. Striatal phantom and patient data showed strong correlations with respect to striatal ratios (R = 0.99 and R = 0.92; p < 0.05 and p < 0.01, respectively). Slightly higher ratios were found for the NeuroFocus patient data, probably due to differences in system performance. Visual assessment of [123I]FP-CIT scans showed agreement between systems in 13 of the 14 cases. We conclude that [123I]FP-CIT SPECT imaging can be performed adequately on the new InSPira system.

Striatal Dopamine Transporter Availability Is Not Associated with Food Craving in Lean and Obese Humans; a Molecular Imaging Study

“…Finally, to be able to study a large population, we included subjects from multiple studies that were performed on two different scanners. However, as we have previously demonstrated that striatal ratios are closely correlated between both cameras [ 37 ], and lean subjects and subjects with obesity were equally distributed between both cameras, it is unlikely that a difference between both cameras has significantly affected our findings.…”

“…SPECT imaging was performed on one of two brain-dedicated cameras: (i) the InSPira HD system (Neurologica, Boston, MA, USA), acquisition time per slice 180 s, slice thickness 4 mm; or (ii) the 12-detector, single-slice brain-dedicated scanner (Neurofocus 810; Strichman Medical Equipment, Cleveland, OH, USA), acquisition time per slice 210 s, slice thickness 5 mm. SPECT images were corrected for attenuation, and reconstructed as previously described [ 37 , 38 ]. We have previously demonstrated that striatal ratios are closely correlated between both cameras [ 37 ].…”

“…SPECT images were corrected for attenuation, and reconstructed as previously described [ 37 , 38 ]. We have previously demonstrated that striatal ratios are closely correlated between both cameras [ 37 ].…”

Artificial Intelligence-Based Assistance in Clinical 123I-FP-CIT SPECT Scan Interpretation

“…Furthermore, it has to be noticed that all our testing and training data originates from general purpose SPECT cameras. Images from dedicated brain scanners, like the InSPira HD SPECT system [23], might lead to diagnoses that are based on detailed local diminished uptake, as can be seen with such highresolution systems. Preliminary results (data not shown) of our model using a test set of DaTSCAN images acquired on the InSPira HD SPECT system indeed showed that the model did not generalize well enough for data from a dedicated brain scanner.…”

Case 6: Parkinson’s Disease with Left-Sided Spasticity

“…The patient received a dopamine transporter SPECT scan of the brain according to a standard protocol that has been described in detail in Chap. 5 and previously [1]. In short, the patient was injected with 120 MBq [ 123 I]FP-CIT (GE Healthcare) and scanned 3 h post-injection on a brain-dedicated SPECT scanner (InSPira).…”