Clinical Evaluation of a Synthetic Hybrid-Scale Matrix in the Treatment of Lower Extremity Surgical Wounds

Abstract

Lower extremity operative wounds can be difficult to treat and are associated with social challenges. New treatment options are needed to mitigate the clinical and social challenges and potentially lower the treatment cost and time. A synthetic hybrid-scale fiber matrix, which has an architecture similar to native tissue, a tailored resorption rate, and excellent durability and handling characteristics, is gaining popularity due to its effectiveness in treating different kinds of wounds. In this retrospective study, nine patients with a total of nine lower extremity wounds and multiple comorbidities were included. The hybrid-scale fiber matrix was cut to wound size, fenestrated as deemed appropriate, and secured to the wound bed using staples or sutures. Wound healing was monitored at subsequent visits, and the synthetic fiber matrix was reapplied as needed. Healing was considered complete when 100% epithelialization and closure of the wound site occurred. Overall, seven out of nine wounds exhibited complete healing and wound closure. For fully healed wounds, the average time to heal was 135.6 days, and good scar quality was observed. This retrospective case series demonstrates the versatility of synthetic hybrid-scale fiber matrices as part of an effective treatment regimen for difficult-to-treat lower extremity operative wounds.

Clinical Application of Bioresorbable, Synthetic, Electrospun Matrix in Wound Healing

“…A limited number of electrospun scaffold products have been successfully translated into human clinical use due to the challenges associated with commercialization, including the time and cost associated with product development under FDA design controls, implementation of commercial scale manufacturing, regulatory clearance activities and product distribution. Despite these challenges, recent work by our group has demonstrated the successful design and clinical translation of a novel electrospun hybrid-scale fiber matrix for use in wound management [17,[30][31][32][33][34][35][36][37][38][39][40][41][42][43][44]. Since receiving FDA clearance in 2017, this electrospun matrix has been utilized in multiple clinical and surgical settings and a variety of different wound types and clinical indications [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44].…”

“…Despite these challenges, recent work by our group has demonstrated the successful design and clinical translation of a novel electrospun hybrid-scale fiber matrix for use in wound management [17,[30][31][32][33][34][35][36][37][38][39][40][41][42][43][44]. Since receiving FDA clearance in 2017, this electrospun matrix has been utilized in multiple clinical and surgical settings and a variety of different wound types and clinical indications [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44]. The present review demonstrates the use of a synthetic hybrid-scale fiber matrix in clinical practice and offers collective insight into the efficacy and value of a hybrid-scale fiber matrix across multiple use cases in the wound care and soft tissue repair setting.…”

“…All wounds received 1 application of the synthetic hybrid-scale fiber matrix, and 78% went on to achieve complete wound closure. This retrospective series demonstrates the versatility of the matrix in conjunction with other advanced treatment modalities and is especially important amongst a patient population with multiple comorbidities [38].…”

Management of irradiated post-mastectomy wound dehiscence with synthetic electrospun fiber matrix: a case report

“…The results of a 2018 study showed that 85% of 82 chronic wounds of varying wound origins, such as non-healing (diabetic, venous leg, pressure) ulcers and traumatic, vascular, necrotic, and surgical wounds, healed within 12 weeks after initial treatment with the SEFM (13). Additionally, numerous studies have demonstrated successful SEFM treatment of closing complex surgical wounds to assist in secondary healing or stimulate the formation of granulation tissue necessary for staging reconstructive procedures, such as flaps or skin grafting (13)(14)(15)(16)(17)(18). However, there have been no documented clinical uses of an SEFM in irradiated tissue for enhanced wound healing.…”

Phytoconstituent-Loaded Nanofibrous Meshes as Wound Dressings: A Concise Review

“…Acute wounds can result from explosions, fires, and other accidents, as well as through contact with caustic chemicals or electricity [10]. In fact, most acute wounds completely heal in around 8 to 12 weeks with minimal scarring [11,12]. Some chronic wounds can take up to 12 weeks to heal [13,14].…”