Clinical evaluation of biological rhythm domains in patients with major depression

Abstract

Objective: Sleep, physical activity, and social domains of biological rhythm disruptions may have specific effects on the symptom cluster and severity of depression. However, there is a lack of structured clinical evaluation to specify the domains of biological rhythms in patients with depression. Methods: Ninety drug-naïve subjects with depression and 91 matched healthy controls were recruited for the study. The severity of depression was examined with the Hamilton Rating Scale for Depression (HRSD), while biological rhythm was evaluated using the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN). Results: Patients with depression showed significantly greater biological rhythm disturbances than healthy controls in all domains of BRIAN (sleep, activity, social, and eating). BRIAN-Total correlated positively with HRSD-Total and HRSD-Total without sleep cluster. The sleep and activity domains correlated significantly with HRSD-Total score. Additionally, the sleep, activity, and social domains correlated significantly with HRSD-Total without the sleep cluster score. Regression analysis revealed the activity (b = 0.476, t = 5.07, po0.001) and sleep (b = 0.209, t = 2.056, p = 0.043) domains may predict HRSD-Total score. Conclusion: Consideration of biological rhythm domains in clinical examination and focusing on the sleep and activity domains may hold promise for the management of depression.How to cite this article: Ozcelik M, Sahbaz C. Clinical evaluation of biological rhythm domains in patients with major depression. Braz J Psychiatry. 2020;42:258-263. http://dx.

Differences in the Clinical Picture in Women with a Depressive Episode in the Course of Unipolar and Bipolar Disorder

“…Our patients predominantly showed evening chronotype, which is consistent with the previous studies [ 2 , 45 ]. This chronotype shows a correlation with the higher ESS results, which indicate daytime sleepiness.…”

“…It clearly shows that the illness has an impact on daytime sleepiness. Ozcelik and Sahbaz [ 2 ] used the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN). They revealed not only problems with sleep, but also disturbances in social relations, activity, and eating.…”

“…About 4.4% of the global population suffers from UP [ 1 ]. Major depressive disorder is a chronic and recurrent disease that manifests with multiple symptoms, including mental and physical features [ 2 ]. Major depression significantly impairs an individual’s ability to function at work or school, and cope with everyday life [ 1 ].…”

Hypothalamic Gene Expression and Postpartum Behavior in a Genetic Rat Model of Depression

“…WMIs self-directed behaviors are decreased and WMIs show no diurnal rhythm in these behaviors while WLI dams do. This is similar to the biological rhythm disturbances observed in patients with depression compared to healthy controls (Mondin et al, 2017;Ozcelik and Sahbaz, 2020). Hypothalamic expression of Kdm5a, Per1, and Per2 is greater in WMIs than WLIs, both in dams whose litter died before postpartum day 5 and in those whose litter survived to wean.…”

“…Some data demonstrate that patients with depression may have an altered sensitivity to light (Duncan, 1996). Additionally, greater biological rhythm disturbances have been observed in patients with depression compared to healthy controls (Mondin et al, 2017;Ozcelik and Sahbaz, 2020). Sleep disturbances have also been observed in WKYs (Dugovic et al, 2000;Dasilva et al, 2011), very similar to those described in depressed patients (Rosenwasser and Wirz-Justice, 1997).…”