Clinical evaluation of ID NOW influenza A &amp; B 2, a rapid influenza virus detection kit using isothermal nucleic acid amplification technology - A comparison with currently available tests

Mitamura, Keiko; Shimizu, Hideaki; Yamazaki, Masahiko; Ichikawa, Masataka; Abe, Takashi; Yasumi, Yuki; Ichikawa, Yoko; Shibata, Toru; Yoshihara, Masaaki; Shiozaki, Ken; Baba, Shinji; Kudo, Yoshihisa; Takahashi, Masahīko; Konomi, Yasushi; Kawakami, Chiharu

doi:10.1016/j.jiac.2019.08.015

Cited by 12 publications

(11 citation statements)

References 12 publications

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“…In our study, in which patients were tested within 48 hours after the onset of ILI, the sensitivity of ImunoAce Flu in the detection of influenza A was as high as the sensitivity of rapid molecular tests [25]. However, the specificity of ImunoAce Flu within 48 hours after the onset of illness was 90.4% (Table 2), which was lower than the specificity of rapid molecular assays [9] [25]. Similarly, in a report from Japan [25], sensitivity and specificity of an RIDT, QUICKNAVI (Otsuka Pharmaceutical Co, Japan) were comparable to the sensitivity and specificity of a rapid molecular assay, ID NOW2.…”

Section: Plos Onementioning

confidence: 65%

“…However, the specificity of ImunoAce Flu within 48 hours after the onset of illness was 90.4% (Table 2), which was lower than the specificity of rapid molecular assays [9] [25]. Similarly, in a report from Japan [25], sensitivity and specificity of an RIDT, QUICKNAVI (Otsuka Pharmaceutical Co, Japan) were comparable to the sensitivity and specificity of a rapid molecular assay, ID NOW2. Based on the Japanese experience, RIDTs are sufficiently sensitive and highly useful if patients are tested within 48 hours after the onset of illness.…”

Section: Plos Onementioning

confidence: 88%

“…According to the meta-analysis [9], the pooled sensitivity and specificity of rapid molecular tests for influenza A were 87.4% (95%CI: 71.1-95.6) and 99.0% (95%CI: 93.2-99.5), respectively, in adults. The sensitivity and specificity of a rapid molecular test, ID NOW2 (Abott Diagnostics, USA), for influenza A were reported to be 95.9% (95%CI: 89.9-98.9) and of 100% (95%CI: 98.1-100), respectively [25], which was reported from Japan, and most patients-mainly children-were tested within 48 hours after the onset of illness. In our study, in which patients were tested within 48 hours after the onset of ILI, the sensitivity of ImunoAce Flu in the detection of influenza A was as high as the sensitivity of rapid molecular tests [25].…”

Section: Plos Onementioning

confidence: 99%

“…The sensitivity and specificity of a rapid molecular test, ID NOW2 (Abott Diagnostics, USA), for influenza A were reported to be 95.9% (95%CI: 89.9-98.9) and of 100% (95%CI: 98.1-100), respectively [25], which was reported from Japan, and most patients-mainly children-were tested within 48 hours after the onset of illness. In our study, in which patients were tested within 48 hours after the onset of ILI, the sensitivity of ImunoAce Flu in the detection of influenza A was as high as the sensitivity of rapid molecular tests [25]. However, the specificity of ImunoAce Flu within 48 hours after the onset of illness was 90.4% (Table 2), which was lower than the specificity of rapid molecular assays [9] [25].…”

Section: Plos Onementioning

confidence: 99%

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Very high sensitivity of a rapid influenza diagnostic test in adults and elderly individuals within 48 hours of the onset of illness

2020

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During influenza epidemics, Japanese clinicians routinely perform rapid influenza diagnostic tests (RIDTs) in the examination of patients who have an influenza-like illness, and patients with positive test results, including otherwise healthy individuals, are treated with anti-influenza drugs. However, it was recently reported that the sensitivity of RIDTs was extremely low in adult patients. We examined the sensitivity and specificity of an RIDT that is widely used in Japan, ImunoAce Flu (TAUNS, Shizuoka, Japan), in comparison to reverse transcriptase polymerase chain reaction (RT-PCR). The sensitivity and specificity of the Imu-noAce Flu test were 97.1% (95%CI: 93.8-98.9) and 89.2% (95%CI: 84.1-93.1), respectively. The ImunoAce Flu test is designed to not only detect influenza A or B, but also to detect H1N1pdm09 with the use of an additional test kit (Linjudge FluA/pdm). Its sensitivity and specificity for A/H1N1pdm09 were 97.6% (95%CI: 87.4-99.9) and 92.6% (95%CI: 82.1-97.9), respectively. Thus, by consecutively testing patients with the ImunoAce Flu test followed by the Linjudge FluA/pdm test, we are able to diagnose whether a patient has A/ H1N1pdm09 or A/H3N2 infection within a short time. The reliability of rapid test results seems to be much higher in Japan than in other countries, because approximately 90% of influenza patients are tested and treated within 48 hours after the onset of illness, when the influenza viral load in the upper respiratory tract is high. From the Japanese experience, RIDTs are sufficiently sensitive and highly useful, if patients are tested within 48 hours after the onset of illness.

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Section: Plos Onementioning

confidence: 65%

Section: Plos Onementioning

confidence: 88%

Section: Plos Onementioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

See 2 more Smart Citations

Very high sensitivity of a rapid influenza diagnostic test in adults and elderly individuals within 48 hours of the onset of illness

2020

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“…It can also reduce the observation time of suspected patients and avoid abuse of antibiotics [ 5 ]. The recommended time to take antiviral treatment is within two days from illness onset [ 6 ]. However, the current “gold standard” diagnostic method in hospital, namely virus culture, unfortunately requires several days [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Rapid Enrichment and Ultrasensitive Detection of Influenza A Virus in Human Specimen using Magnetic Quantum Dot Nanobeads Based Test Strips

Bai

Wei

Yang

et al. 2020

Sensors and Actuators B: Chemical

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Evaluation of a novel rapid TRC assay for the detection of influenza using nasopharyngeal swabs and gargle samples

Kaku

Hashiguchi

Akamatsu

et al. 2021

Eur J Clin Microbiol Infect Dis

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We evaluated a novel transcription-reverse transcription concerted reaction (TRC) assay that can detect influenza A and B within 15 min using nasopharyngeal swab and gargle samples obtained from patients with influenza-like illness, between January and March 2018 and between January and March 2019. Based on the combined RT-PCR and sequencing results, in the nasal swabs, the sensitivity and specificity of TRC for detecting influenza were calculated as 1.000 and 1.000, respectively. In the gargle samples, the sensitivity and specificity of TRC were 0.946 and 1.000, respectively. The TRC assay showed comparable performance to RT-PCR in the detection of influenza viruses.

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Clinical evaluation of ID NOW influenza A & B 2, a rapid influenza virus detection kit using isothermal nucleic acid amplification technology - A comparison with currently available tests

Cited by 12 publications

References 12 publications

Very high sensitivity of a rapid influenza diagnostic test in adults and elderly individuals within 48 hours of the onset of illness

Very high sensitivity of a rapid influenza diagnostic test in adults and elderly individuals within 48 hours of the onset of illness

Rapid Enrichment and Ultrasensitive Detection of Influenza A Virus in Human Specimen using Magnetic Quantum Dot Nanobeads Based Test Strips

Evaluation of a novel rapid TRC assay for the detection of influenza using nasopharyngeal swabs and gargle samples

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