Clinical evaluation of low dose intradermally administered hepatitis B vaccine: a comparison of plasma-derived and recombinant yeast-derived vaccines

Sõyletır, Gũner; Bahceci, Erkut; Akoğlu, Emel; Soyogul, Ü. Gürer; Lawrance, R.A.

doi:10.1016/0264-410x(92)90367-s

Cited by 7 publications

(4 citation statements)

References 14 publications

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“…Otherwise, the higher immunogenicity, safety, efficacy of the recombinant DNA-derived hepatitis B vaccines than plasma-derived vaccine was reported by other researchers [Hayashi et al, 1988;Most et al, 1992;Soyletir et al, 1992]. Lu et al [2004] who found unacceptably high rates of undetectable anti-HBs among children who had received four doses of plasma-derived hepatitis B vaccine as the neonatal immunization 15 years previously.…”

Section: Discussionmentioning

confidence: 91%

Seroepidemiology of hepatitis A, B, C, and E viruses infection among preschool children in Taiwan

Lin

Chen

et al. 2005

Journal of Medical Virology

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Taiwan was a hyperendemic area for hepatitis A and B viruses (HAV and HBV) infection before late 1980s. To study the seroprevalence of hepatitis A, B, C, and E viruses (HCV and HEV) infection among preschool children in Taiwan, a community‐based survey was carried out in 54 kindergartens in 10 urban areas, 10 rural areas, and 2 aboriginal areas randomly selected through stratified sampling. Serum specimens of 2,538 preschool children were screened for the hepatitis A, C, and E antibodies by a commercially available enzyme immunoassay and for HBV markers by radioimmunoassay methods. The multivariate‐adjusted odd ratios (OR) with their 95% confidence intervals (CI) were estimated through the multiple logistic regression analysis. Females had a statistically significantly higher HAV seroprevalence than males. The seroprevalence of HCV infection increased significantly with age. The larger the sibship size, the higher the seroprevalence of HBV infection. Aboriginal children had a significantly higher seroprevalence of HBV and HEV infection and lower seroprevalence of HCV infection than non‐aboriginal children. A significantly higher seroprevalence of HBV infection was found in rural children than urban children. There was no significant association between serostatus of HAV and HEV infection and between serostatus of HBV and HCV infection among preschool children in Taiwan. The poor environmental and hygienic conditions in the aboriginal areas might play a role in infection with HBV and HEV. J. Med. Virol. 78:18–23, 2006. © 2005 Wiley‐Liss, inc.

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Section: Discussionmentioning

confidence: 91%

Seroepidemiology of hepatitis A, B, C, and E viruses infection among preschool children in Taiwan

Lin

Chen

et al. 2005

Journal of Medical Virology

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“…Studies with low-dose (2-4 µg) im immunization with plasma-derived HB vaccines with a three or four-dose schedule reported seroconversion rates of 74-97% in neonates, children and healthy young adults [1]. The results of low-dose HB vaccination in Turkey are also encouraging; seroconversion rates of 83-100% have been reported [5][6][7].…”

Section: Discussionmentioning

confidence: 88%

“…Initial studies were performed with plasma-derived vaccines administered id. In most of these studies, protective levels of anti-HBs could be achieved in 67-100% of young healthy adults, although the levels of antibody were lower with reduced doses [1][2][3][4][5]. Low-dose (2 µg) im injections have been attempted because the id injection technique requires trained personnel and more time.…”

Section: Discussionmentioning

confidence: 97%

Low-Dose Intramuscular Hepatitis B Vaccination in Medical Students: 4-Year Follow-Up

Erensoy¹,

Bilgiç²,

Arda³

et al. 2002

Infection

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“…The anti-HBs seroconversion rates were similar in the first two groups (99.1 and 94.6%, respectively, with a high mean serum anti-HBs concentration), and lower (78.6%) in the third group, which showed a very low mean serum antiHBs concentration. Söyletir et al (1992) demonstrated a 100% seroconversion rate in 21 adults injected intradermally with 2 µg doses of the Belgian recombinant vaccine at 0, 1, and 6 months, with the mean serum anti-HBs titer reaching 1390 mIU/ml.…”

Section: Discussionmentioning

confidence: 99%

Intradermal vaccination of adults with three low doses (2 µg) of recombinant hepatitis B vaccine. I. Seroconversion rate and adverse effects

Baldy

Elisbão

Anzai

et al. 2003

Mem. Inst. Oswaldo Cruz

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Clinical evaluation of low dose intradermally administered hepatitis B vaccine: a comparison of plasma-derived and recombinant yeast-derived vaccines

Cited by 7 publications

References 14 publications

Seroepidemiology of hepatitis A, B, C, and E viruses infection among preschool children in Taiwan

Seroepidemiology of hepatitis A, B, C, and E viruses infection among preschool children in Taiwan

Low-Dose Intramuscular Hepatitis B Vaccination in Medical Students: 4-Year Follow-Up

Intradermal vaccination of adults with three low doses (2 µg) of recombinant hepatitis B vaccine. I. Seroconversion rate and adverse effects

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