Clinical Evaluation of Mineralized Collagen as a Bone Graft Substitute for Anterior Cervical Intersomatic Fusion

Abstract

Although autograft is a routine procedure in anterior interbody fusion of the cervical spine, donor site morbidity is a significant problem. Many bone grafting materials developed such as allograft bone, demineralized bone matrix (DBM), and synthetic implants were used to repair bony defects; however, each has its specific disadvantage. Therefore, alternative materials for autogenous bone in grafting are needed. Ninety-one patients with symptomatic cervical disc diseases were randomly allocated for either autologous iliac crest bone graft (AIG) or mineralized collagen (MC). Clinical and radiological comparisons were performed for the two groups. Patients were followed-up routinely in the outpatient clinic, where clinical and radiological evaluations were taken. The mean operation time to perform AIG and MC was 194 ± 37 and 121 ± 26 minutes, respectively. The mean volume of blood loss during the operation was 140 ± 41 and 79 ± 25 mL for AIG and MC, respectively. The mean length of hospitalization due to AIG and MC was 9 7 ± 0 7 and 5 9 ± 0 8 days, respectively. The clinical outcomes were identical, and fusion rates were similar between the two groups. This study shows effective results of MC in anterior cervical intersomatic fusion. MC may be a promising substitute for autologous iliac crest bone graft.

Biomimetic cartilage scaffold with orientated porous structure of two factors for cartilage repair of knee osteoarthritis

“…In the outermost superficial zone collagen fibrils are oriented parallel to the articulating surface and in the middle and calcified zones, the collagen fibrils are random and perpendicular. COL has been widely used in cartilage tissue engineering due to its excellent biocompatibility, negligible immunogenicity, cell adhesion and biodegradability [18,19]. COL can also specifically interact with growth factors which promote cell ingrowth and remodelling [20,21].…”

The effect of calcium phosphate composite scaffolds on the osteogenic differentiation of rabbit dental pulp stem cells

“…[33][34][35] Cell culture and animal model tests showed that the composite material was highly osteoconductive, biocompatible, and bioresorbable. [33][34][35] Cell culture and animal model tests showed that the composite material was highly osteoconductive, biocompatible, and bioresorbable.…”

“…The nHAC/PLA, produced by Beijing Allgens Medical Science & Technology Co., Ltd., is attractive as bone substitute because the novel biomimetic strategy used to generate it provides properties similar to natural bone. [33][34][35] Cell culture and animal model tests showed that the composite material was highly osteoconductive, biocompatible, and bioresorbable. [36][37][38] Our previous study has demonstrated that the nHAC/PLA can be served as a good scaffold for autologous rabbit DPSCs seeding, proliferation and differentiation, and can induce transplanted DPSCs to reconstruct rabbit alveolar bone defects.…”

The mineralized collagen for the reconstruction of intra-articular calcaneal fractures with trabecular defects

“…Extensive vitro and animal studies have that demonstrated MC has excellent biocompatibility, biodegradability, high osteoconducitive activity, and promotes bone repair and regeneration. [10][11][12] Recently MC has been evaluated in spinal fusion. In a series of 91 patients who underwent two-or three-level ACDF with rigid anterior plate fixation with either autologous or MC, the results demonstrated 95.7% fusion rate for MC with results comparable to those with autologous bone which was 100%.…”

“…Previous in vivo preclinical and clinical trials have shown MC is a safe and promising substitute for autologous iliac crest bone graft. [10][11][12] It has now been approved by the China Food and Drug Administration as a class III medical device.…”