Clinical Evaluation of Pinggan Yiqi Yangshen Recipe Combined with Labetalol Hydrochloride and Magnesium Sulfate in the Treatment of PIH

Li, Ping; Zhao, Jie; Gao, Peipei; Qu, Hongcui

doi:10.1155/2021/3135043

Cited by 3 publications

(3 citation statements)

References 35 publications

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“…Studies suggested that the exclusive treatment of magnesium sulfate to treat pregnancy-induced hypertension (PIH) will affect fetal development ( Pascoal et al, 2019 ). Li et al ( Li et al, 2021 ) discussed the use of magnesium sulfate in combination with labetalol, which proved its efficacy in improving delivery outcomes and maternal and fetal outcomes.…”

Section: Discussionmentioning

confidence: 99%

Pharmaceutical administration for severe hypertension during pregnancy: Network meta-analysis

et al. 2023

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Aims: To evaluate the efficacy of different pharmacologic treatment for severe hypertension during pregnancy.Methods: Two reviewers searched Ovid MEDLINE, Ovid EMbase, and the Cochrane Library for randomized clinical trials from the establishment of the database to 15 July 2021 that were eligible for inclusion and analyzed the pharmaceuticals used for severe hypertension in pregnancy.Results: 29 relevant trials with 2,521 participants were involved. Compared with diazoxide in rate of achieving target blood pressure, other pharmaceuticals, including epoprostenol (RR:1.58, 95%CI:1.01–2.47), hydralazine\dihydralazine (RR:1.57, 95%CI:1.07–2.31), ketanserin (RR:1.67, 95%CI:1.09–2.55), labetalol (RR:1.54, 95%CI:1.04–2.28), nifedipine (RR:1.54, 95%CI:1.04–2.29), and urapidil (RR:1.57, 95%CI:1.00–2.47), were statistically significant in the rate of achieving target blood pressure. According to the SUCRA, diazoxide showed the best therapeutic effect, followed by nicardipine, nifedipine, labetalol, and nitroglycerine. The three pharmaceuticals with the worst therapeutic effect were ketanserin, hydralazine, and urapidil. It is worth noting that the high ranking of the top two pharmaceuticals, including diazoxide and nicardipine, comes from extremely low sample sizes. Other outcomes were reported in the main text.Conclusion: This comprehensive network meta-analysis demonstrated that the nifedipine should be recommended as a strategy for blood pressure management in pregnant women with severe hypertension. Moreover, the conventional pharmaceuticals, including labetalol and hydralazine, showed limited efficacy. However, it was important to note that the instability of hydralazine reducing blood pressure and the high benefit of labetalol with high dosages intakes should also be of concern to clinicians.

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Section: Discussionmentioning

confidence: 99%

Pharmaceutical administration for severe hypertension during pregnancy: Network meta-analysis

et al. 2023

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“…Therefore, in order to improve the antihypertensive effect and improve the delivery outcome, clinical treatment should actively explore effective means. Li et al [ 21 ] believed that the combination of magnesium sulfate and labetalol had an obvious therapeutic effect on PIH, which could effectively improve the delivery outcome and prognosis. This is similar to the result of this study.…”

Section: Discussionmentioning

confidence: 99%

Uterine Ultrasound Doppler Hemodynamics of Magnesium Sulfate Combined with Labetalol in the Treatment of Pregnancy-Induced Hypertension Using Empirical Wavelet Transform Algorithm

Liu

Wang

Yin

2022

Computational Intelligence and Neuroscience

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The aim of this study was to explore the hemodynamic changes of magnesium sulfate combined with labetalol in the treatment of pregnancy-induced hypertension (PIH) under Doppler uterine ultrasound based on the empirical wavelet transform (EWT) algorithm. 500 patients with PIH in the hospital were selected and randomly divided into the control group (n = 250) and the observation group (n = 250). The control group was treated with conventional magnesium sulfate; the observation group was given labetalol based on magnesium sulfate drip in the control group. The uterine artery blood flow simulation model was established based on the EWT algorithm and compared with a short-time Fourier transform (STFT). The normalized root mean square error (NRMSE) of the STFT method was 0.19, and the NRMSE extracted by the EWT method was 0.13. After treatment, the blood pressure index, 24-hour urinary protein, and incidence of adverse birth outcomes in the observation group were lower than those in the control group; the effective rate of the control group (90.4%) was lower than that of the observation group (97.6%); the hemodynamic indexes of the uterine artery in the observation group were lower than those in the control group, and the differences were statistically significant ( P < 0.05 ). The estimation accuracy of the EWT method was higher than that of the traditional STFT method; the combined treatment of magnesium sulfate and labetalol in patients with PIH had a remarkable effect, which could control the blood pressure index and reduce the 24-hour urinary protein; the uterine artery Doppler ultrasound examination could change hemodynamics and improve the adverse outcomes of mothers and infants.

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“…Not only can PE cause heart, liver, brain, and kidney failure, but it can also lead to premature abortion or stillbirth (Hsieh-Lo et al 2020). If GH cannot be controlled timely and effectively, it is easy to develop into severe PE, which is a serious threat to the life safety of both the pregnant women and the fetus (Li et al 2021).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Diagnostic and Prognostic Value of Deregulated Long Non-Coding RNA Plasmacytoma Variant Translocation 1 in Patients with Gestational Hypertension

Gao

et al. 2023

Tohoku J. Exp. Med.

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This study aimed to investigate the serum plasmacytoma variant translocation 1 (PVT1) level in pregnant women with gestational hypertension (GH) and pre-eclampsia (PE) and its diagnostic value for diseases and its influence on pregnancy outcome. Serum PVT1 levels in 72 GH pregnant women, 72 PE pregnant women and 71 healthy pregnant women were evaluated by RT-qPCR, and the diagnostic significance of PVT1 for GH was verified by receiver operator characteristic (ROC) curve. The correlation between PVT1 and clinical indicators were evaluated by Pearson correlation coefficient method. Logistic regression analysis evaluated the influencing factors in the development process of GH to PE. The effect of PVT1 level on pregnancy outcome was evaluated by prognostic analysis. Results showed that PVT1 level was downregulated in GH group compared with HC group, whereas PVT1 level was downregulated more significantly in PE group than in GH group. ROC curve showed that PVT1 had high diagnostic accuracy for GH. Pearson correlation coefficient and multiple linear regression analysis showed that PVT1 was correlated with systolic blood pressure (SBP), diastolic blood pressure (DBP), interleukin (IL)-6 and tumor necrosis factor (TNF)-α. Logistic regression analysis revealed that IL-6 and PVT1 were the influencing factors of GH to PE transition. Moreover, prognostic analysis manifested that the incidence of fetal growth restriction in low PVT1 expression group was significantly higher than that in high PVT1 expression group. The expression level of PVT1 has a high diagnostic accuracy for GH, and the low PVT1 expression group is more prone to fetal growth restriction.

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Clinical Evaluation of Pinggan Yiqi Yangshen Recipe Combined with Labetalol Hydrochloride and Magnesium Sulfate in the Treatment of PIH

Cited by 3 publications

References 35 publications

Pharmaceutical administration for severe hypertension during pregnancy: Network meta-analysis

Pharmaceutical administration for severe hypertension during pregnancy: Network meta-analysis

Uterine Ultrasound Doppler Hemodynamics of Magnesium Sulfate Combined with Labetalol in the Treatment of Pregnancy-Induced Hypertension Using Empirical Wavelet Transform Algorithm

Diagnostic and Prognostic Value of Deregulated Long Non-Coding RNA Plasmacytoma Variant Translocation 1 in Patients with Gestational Hypertension

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