Clinical evaluation of the safety and efficacy of a timosaponin A‐III‐based antiwrinkle agent against skin aging

Im, A‐Rang; Seo, Young Kyoung; Cho, Se Hee; O, Kyeong Hee; Kim, Ki Mo; Chae, Sungwook

doi:10.1111/jocd.13035

Cited by 16 publications

(5 citation statements)

References 37 publications

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“…Based on the above results, a clinical efficacy evaluation was conducted [ 25 , 26 , 27 ]. All tests were performed following ethical regulations.…”

Section: Resultsmentioning

confidence: 99%

High Stability and Low Irritation of Retinol Propionate and Hydroxypinacolone Retinoate Supramolecular Nanoparticles with Effective Anti-Wrinkle Efficacy

Bai

Xu³

et al. 2023

Pharmaceutics

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Gravi-A nanoparticles, composed of retinyl propionate (RP) and hydroxypinacolone retinoate (HPR), were prepared by encapsulating the two using the high-pressure homogenization technique. The nanoparticles are effective in anti-wrinkle treatment with high stability and low irritation. We evaluated the effect of different process parameters on nanoparticle preparation. Supramolecular technology effectively produced nanoparticles with spherical shapes with an average size of 101.1 nm. The encapsulation efficiency was in the 97.98–98.35% range. The system showed a sustained release profile for reducing the irritation caused by Gravi-A nanoparticles. Furthermore, applying lipid nanoparticle encapsulation technology improved the transdermal efficiency of the nanoparticles, thereby allowing these to penetrate deep into the dermis layer to achieve precise and sustained release of active ingredients. Gravi-A nanoparticles can be extensively and conveniently used in cosmetics and other related formulations by direct application.

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“…Based on the above results, a clinical efficacy evaluation was conducted [ 25 , 26 , 27 ]. All tests were performed following ethical regulations.…”

Section: Resultsmentioning

confidence: 99%

High Stability and Low Irritation of Retinol Propionate and Hydroxypinacolone Retinoate Supramolecular Nanoparticles with Effective Anti-Wrinkle Efficacy

Bai

Xu³

et al. 2023

Pharmaceutics

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“…The detailed methodology of this study has been described in our previous reports. 14 – 16 For determination of SE type before the study, the subjects were asked to fill out the Sasang Constitution Diagnostic Survey, their body mass index (using Inbody® 330; Biospace, Korea) and body circumference were measured, and they were photographed. The SE subjects were selected by using a Sasang Constitution Diagnosis Program (SCAT, Sasang Constitutional Analysis Tool) developed by the Korea Institute of Oriental Medicine.…”

Section: Methodsmentioning

confidence: 99%

Wrinkle reduction using a Sasang constitutional medicine-based topical herbal cream in So-eum subjects: A split-face randomized double-blind placebo-controlled study

Nam

et al. 2022

Integrative Medicine Research

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Background Skin aging is caused by exogenous and endogenous factors and is commonly manifested as wrinkling, sagging, and looseness of the skin. The herbal extract including Zingiber officinale Roscoe, Atractylodes chinensis (Bunge) Kodiz, Curcuma longa L., and Cinnamomum cassia (L.) J.Presl (ZACC extract), is widely used for So-eum (SE) Sasang constitutional type individuals. This study aimed to examine the protective effects of the ZACC extract against skin aging in 21 SE type subjects. Methods The safety and clinical efficacy of herbal cream were evaluated after application on human skin in a split-face randomized, double-blind, placebo-controlled study. The Sasang Constitution Analysis Tool (SCAT) was used to select 21 SE type subjects, who applied herbal cream and placebo cream for 12 weeks. Visual assessment, wrinkle parameters, questionnaires, and skin safety were evaluated. Results The visual assessment score was decreased by using of the herbal cream, but there were no significant differences between groups. Among the wrinkle parameters, R1 (skin roughness) and R4 (smoothness depth) values were significantly improved after the application of the herbal cream compared to those observed after application of the placebo cream for 12 weeks. No significant differences were observed in evaluation of the product efficacy and usability by questionnaires. There were no adverse dermatologic reactions in the SE type subjects during the evaluation period. Conclusion The ZACC herbal cream may be used to prevent or slow skin aging, including wrinkle formation, in SE type individuals.

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“…Female subjects (n = 21) aged between 43 and 55 years old, who had begun to form or had already-formed wrinkles and who met the selection criteria of subjects were selected, and the agent containing 0.25% of TA-III was applied for 12 weeks. The results showed that wrinkles were significantly reduced, and that secreted MMP-1 was reduced, which had the effect of resisting photoaging [ 70 ]. This revealed that the TA-III had the effect of treating skin aging.…”

Section: Research On Skin Anti-aging Compoundsmentioning

confidence: 99%

Research Progress on Skin Aging and Active Ingredients

Wan

et al. 2023

Molecules

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With the advancement of living standards in modern society and the emergence of an aging population, an increasing number of people are becoming interested in the topic of aging and anti-aging. An important feature of aging is skin aging, and women are particularly concerned about skin aging. In the field of cosmetics, the market share of anti-aging products is increasing year by year. This article reviews the research and development progress of skin aging and related active compounds both domestically and internationally in recent years. The results show that, in terms of the research on skin aging, the popular theories mainly include free radicals and oxidative stress theory, inflammation theory, photoaging theory, and nonenzymatic glycosyl chemistry theory. In terms of research on the active ingredients with anti-aging activities in the skin, there are numerous reports on related products in clinical studies on human subjects, animal experiments, and experimental studies on cell cultures, with a variety of types. Most of the compounds against skin aging are sourced from natural products and their action mechanisms are mainly related to scavenging oxygen free radicals and enhancing antioxidant defenses. This review provides important references for the future research of skin aging and the development of related products. Although there is a great progress in skin aging including related active ingredients, ideal compounds or products are still lacking and need to be further validated. New mechanisms of skin aging, new active ingredients sourced from natural and artificial products, and new pharmaceutical forms including further clinical validations should be further investigated in the future.

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Clinical evaluation of the safety and efficacy of a timosaponin A‐III‐based antiwrinkle agent against skin aging

Cited by 16 publications

References 37 publications

High Stability and Low Irritation of Retinol Propionate and Hydroxypinacolone Retinoate Supramolecular Nanoparticles with Effective Anti-Wrinkle Efficacy

High Stability and Low Irritation of Retinol Propionate and Hydroxypinacolone Retinoate Supramolecular Nanoparticles with Effective Anti-Wrinkle Efficacy

Wrinkle reduction using a Sasang constitutional medicine-based topical herbal cream in So-eum subjects: A split-face randomized double-blind placebo-controlled study

Research Progress on Skin Aging and Active Ingredients

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