This study investigated whether insulin-like growth factor 1 receptor (IGF1R) single-nucleotide polymorphisms (SNPs) are associated with the development of papillary thyroid cancer (PTC) and their clinicopathologic features in the Korean population. One hundred and five PTC patients and 312 control subjects were enrolled. Two exonic SNPs (rs3743262, Thr766Thr; rs2229765, Glu1043Glu) in IGF1R were genotyped using direct sequencing. SNPStats, SPSS 18.0, and Haploview version 4.2 programs were used to evaluate genetic data. Multiple logistic regression models were used to determine odds ratios (ORs), 95% confidence intervals (CIs), and P values. A SNP (rs2229765) was associated with the development of PTC (OR = 0.56, 95% CI = 0.35-0.89, P = 0.016 in a codominant model 1; OR = 0.29, 95% CI = 0.11-0.78, P = 0.012 in a codominant model 2; OR = 0.51, 95% CI = 0.32-0.79, P = 0.0028 in a dominant model; OR = 0.38, 95% CI = 0.15-1.01, P = 0.031 in a recessive model; OR = 0.55, 95% CI = 0.38-0.80, P = 0.0001 in a log-additive model; OR = 1.78, 95% CI = 1.25-2.54, P = 0.002 in allele distribution). Our data suggest that the IGF1R may be a risk factor of susceptibility in PTC.

There are two categories of aging process with intrinsic and extrinsic aging. The former is represented by internal factors as accompanied by genetic events, and the latter is related to external factors such as stress, radiation, pollution, and smoking. 1 Aging skin has features in changes in skin thickness, epidermal and dermal layer which appear as wrinkles, and structural abnormalities including degeneration of dermal elastic fibers. 2 Clinically, the skin becomes coarse, then thins, and becomes lax, showing sallowness, wrinkles, irregular hyperpigmentation, lentigines, and telangiectasias. 3 As people grow older, they become interested in the condition of their skin. 4 Skin wrinkles are typical phenomena of aging with morphological changes in relation to dermal function with breakdown